Erxian Decoction Attenuates TNF-α Induced Osteoblast Apoptosis by Modulating the Akt/Nrf2/HO-1 Signaling Pathway

Erxian Decoction Attenuates TNF-α Induced Osteoblast Apoptosis by Modulating the Akt/Nrf2/HO-1 Signaling Pathway

Erxian decoction (EXD), a traditional Chinese medicine formula, has been used for treatment of osteoporosis for many years. The purpose of this study was to investigate the pharmacological effect of EXD in preventing osteoblast apoptosis and the underlying mechanism of prevention. Putative targets o...

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Bibliographic Details
Main Authors: Nani Wang, Hailiang Xin, Pingcui Xu, Zhongming Yu, Dan Shou
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Pharmacology
Subjects:
network pharmacology
Erxian decoction
osteoporosis
Akt
tumor necrosis factor
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00988/full

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