The evaluation of PIK3CA gene variation and serum PI3K level in breast cancer risk and prognosis in Turkish population
The PI3K (Phosphatidylinositol 3-kinase) is the member of lipid kinase family that plays important roles in tumorigenesis, cancer development and cell proliferation. In our study, we aimed to investigate the relationships between breast cancer risk and prognosis with PIK3CA rs6443624 (C>A) intron...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2021-11-01
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| Series: | Türk Biyokimya Dergisi |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/tjb-2021-0072 |
| _version_ | 1818548683583520768 |
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| author | Ulu Elif Yaylım İlhan Arıkan Soykan Cacına Canan |
| author_facet | Ulu Elif Yaylım İlhan Arıkan Soykan Cacına Canan |
| author_sort | Ulu Elif |
| collection | DOAJ |
| description | The PI3K (Phosphatidylinositol 3-kinase) is the member of lipid kinase family that plays important roles in tumorigenesis, cancer development and cell proliferation. In our study, we aimed to investigate the relationships between breast cancer risk and prognosis with PIK3CA rs6443624 (C>A) intron region gene polymorphism and serum PI3K levels. |
| first_indexed | 2024-12-12T08:23:28Z |
| format | Article |
| id | doaj.art-cf652f43050b4977b8ec87385f70a5ac |
| institution | Directory Open Access Journal |
| issn | 1303-829X |
| language | English |
| last_indexed | 2024-12-12T08:23:28Z |
| publishDate | 2021-11-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Türk Biyokimya Dergisi |
| spelling | doaj.art-cf652f43050b4977b8ec87385f70a5ac2022-12-22T00:31:20ZengDe GruyterTürk Biyokimya Dergisi1303-829X2021-11-0147331732410.1515/tjb-2021-0072The evaluation of PIK3CA gene variation and serum PI3K level in breast cancer risk and prognosis in Turkish populationUlu Elif0Yaylım İlhan1Arıkan Soykan2Cacına Canan3Department of Molecular Medicine, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, TurkeyDepartment of Molecular Medicine, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, TurkeyGeneral Surgery Clinics, Istanbul Education and Research Hospital, Istanbul, TurkeyDepartment of Molecular Medicine, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, TurkeyThe PI3K (Phosphatidylinositol 3-kinase) is the member of lipid kinase family that plays important roles in tumorigenesis, cancer development and cell proliferation. In our study, we aimed to investigate the relationships between breast cancer risk and prognosis with PIK3CA rs6443624 (C>A) intron region gene polymorphism and serum PI3K levels.https://doi.org/10.1515/tjb-2021-0072apoptosisbreast cancerphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (pik3ca)serum levelsingle nucleotide polymorphism (snp)apoptozmeme kanserifosfatidilinozitol-4,5-bifosfat 3-kinaz katalitik alt birim alfa (pik3ca)serum düzeyitek nükleotid polimorfizmi (snp) |
| spellingShingle | Ulu Elif Yaylım İlhan Arıkan Soykan Cacına Canan The evaluation of PIK3CA gene variation and serum PI3K level in breast cancer risk and prognosis in Turkish population Türk Biyokimya Dergisi apoptosis breast cancer phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (pik3ca) serum level single nucleotide polymorphism (snp) apoptoz meme kanseri fosfatidilinozitol-4,5-bifosfat 3-kinaz katalitik alt birim alfa (pik3ca) serum düzeyi tek nükleotid polimorfizmi (snp) |
| title | The evaluation of PIK3CA gene variation and serum PI3K level in breast cancer risk and prognosis in Turkish population |
| title_full | The evaluation of PIK3CA gene variation and serum PI3K level in breast cancer risk and prognosis in Turkish population |
| title_fullStr | The evaluation of PIK3CA gene variation and serum PI3K level in breast cancer risk and prognosis in Turkish population |
| title_full_unstemmed | The evaluation of PIK3CA gene variation and serum PI3K level in breast cancer risk and prognosis in Turkish population |
| title_short | The evaluation of PIK3CA gene variation and serum PI3K level in breast cancer risk and prognosis in Turkish population |
| title_sort | evaluation of pik3ca gene variation and serum pi3k level in breast cancer risk and prognosis in turkish population |
| topic | apoptosis breast cancer phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (pik3ca) serum level single nucleotide polymorphism (snp) apoptoz meme kanseri fosfatidilinozitol-4,5-bifosfat 3-kinaz katalitik alt birim alfa (pik3ca) serum düzeyi tek nükleotid polimorfizmi (snp) |
| url | https://doi.org/10.1515/tjb-2021-0072 |
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