Right inferior frontal gyrus theta-burst stimulation reduces smoking behaviors and strengthens fronto-striatal-limbic resting-state functional connectivity: a randomized crossover trial
IntroductionFunctional and anatomical irregularities in the right inferior frontal gyrus (rIFG), a ventrolateral prefrontal region that mediates top-down inhibitory control over prepotent behavioral responding, are implicated in the ongoing maintenance of nicotine dependence (ND). However, there is...
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1166912/full |
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| author | Spencer Upton Alexander A. Brown Alexander A. Brown Alexander A. Brown Mojgan Golzy Eric L. Garland Brett Froeliger Brett Froeliger Brett Froeliger |
| author_facet | Spencer Upton Alexander A. Brown Alexander A. Brown Alexander A. Brown Mojgan Golzy Eric L. Garland Brett Froeliger Brett Froeliger Brett Froeliger |
| author_sort | Spencer Upton |
| collection | DOAJ |
| description | IntroductionFunctional and anatomical irregularities in the right inferior frontal gyrus (rIFG), a ventrolateral prefrontal region that mediates top-down inhibitory control over prepotent behavioral responding, are implicated in the ongoing maintenance of nicotine dependence (ND). However, there is little research on the effects of neuromodulation of the rIFG on smoking behavior, inhibitory control, and resting-state functional connectivity (rsFC) among individuals with ND.MethodsIn this double-blind, crossover, theta-burst stimulation (TBS) study, adults with ND (N = 31; female: n = 15) completed a baseline session and were then randomized to two counterbalanced sessions of functionally neuronavigated TBS to the rIFG: continuous TBS (cTBS) on 1 day and intermittent TBS (iTBS) on another. Differences in cigarette cravings, smoking, and fronto-striatal-limbic rsFC were assessed.ResultsRelative to baseline, cTBS significantly reduced appetitive and withdrawal cravings immediately after treatment. The effects of cTBS on withdrawal craving persisted for 24 h, as well as produced a reduction in smoking. Furthermore, cTBS significantly strengthened rsFC between the rIFG pars opercularis and subcallosal cingulate (fronto-striatal circuit), and between the rIFG pars opercularis and the right posterior parahippocampal gyrus (fronto-limbic circuit). At post-24 h, cTBS-induced increase in fronto-striatal rsFC was significantly associated with less appetitive craving, while the increase in fronto-limbic rsFC was significantly associated with less withdrawal craving and smoking.DiscussionThese findings warrant further investigation into the potential value of rIFG cTBS to attenuate smoking behavior among individuals with ND. |
| first_indexed | 2024-03-13T02:53:56Z |
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| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-03-13T02:53:56Z |
| publishDate | 2023-06-01 |
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| series | Frontiers in Psychiatry |
| spelling | doaj.art-cf6750d1da6f48bdae4638bd2be2e03f2023-06-28T08:46:46ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402023-06-011410.3389/fpsyt.2023.11669121166912Right inferior frontal gyrus theta-burst stimulation reduces smoking behaviors and strengthens fronto-striatal-limbic resting-state functional connectivity: a randomized crossover trialSpencer Upton0Alexander A. Brown1Alexander A. Brown2Alexander A. Brown3Mojgan Golzy4Eric L. Garland5Brett Froeliger6Brett Froeliger7Brett Froeliger8Department of Psychological Sciences, University of Missouri, Columbia, MO, United StatesDepartment of Psychological Sciences, University of Missouri, Columbia, MO, United StatesDepartment of Psychiatry, School of Medicine, University of Missouri, Columbia, MO, United StatesCognitive Neuroscience Systems Core Facility, University of Missouri, Columbia, MO, United StatesBiostatistics Unit, Department of Family and Community Medicine, School of Medicine, University of Missouri, Columbia, MO, United StatesCenter on Mindfulness and Integrative Health Intervention Development, College of Social Work, University of Utah, Salt Lake City, UT, United StatesDepartment of Psychological Sciences, University of Missouri, Columbia, MO, United StatesDepartment of Psychiatry, School of Medicine, University of Missouri, Columbia, MO, United StatesCognitive Neuroscience Systems Core Facility, University of Missouri, Columbia, MO, United StatesIntroductionFunctional and anatomical irregularities in the right inferior frontal gyrus (rIFG), a ventrolateral prefrontal region that mediates top-down inhibitory control over prepotent behavioral responding, are implicated in the ongoing maintenance of nicotine dependence (ND). However, there is little research on the effects of neuromodulation of the rIFG on smoking behavior, inhibitory control, and resting-state functional connectivity (rsFC) among individuals with ND.MethodsIn this double-blind, crossover, theta-burst stimulation (TBS) study, adults with ND (N = 31; female: n = 15) completed a baseline session and were then randomized to two counterbalanced sessions of functionally neuronavigated TBS to the rIFG: continuous TBS (cTBS) on 1 day and intermittent TBS (iTBS) on another. Differences in cigarette cravings, smoking, and fronto-striatal-limbic rsFC were assessed.ResultsRelative to baseline, cTBS significantly reduced appetitive and withdrawal cravings immediately after treatment. The effects of cTBS on withdrawal craving persisted for 24 h, as well as produced a reduction in smoking. Furthermore, cTBS significantly strengthened rsFC between the rIFG pars opercularis and subcallosal cingulate (fronto-striatal circuit), and between the rIFG pars opercularis and the right posterior parahippocampal gyrus (fronto-limbic circuit). At post-24 h, cTBS-induced increase in fronto-striatal rsFC was significantly associated with less appetitive craving, while the increase in fronto-limbic rsFC was significantly associated with less withdrawal craving and smoking.DiscussionThese findings warrant further investigation into the potential value of rIFG cTBS to attenuate smoking behavior among individuals with ND.https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1166912/fulladdictionsmokingtobaccocravingrepetitive transcranial magnetic stimulationresting state fMRI |
| spellingShingle | Spencer Upton Alexander A. Brown Alexander A. Brown Alexander A. Brown Mojgan Golzy Eric L. Garland Brett Froeliger Brett Froeliger Brett Froeliger Right inferior frontal gyrus theta-burst stimulation reduces smoking behaviors and strengthens fronto-striatal-limbic resting-state functional connectivity: a randomized crossover trial Frontiers in Psychiatry addiction smoking tobacco craving repetitive transcranial magnetic stimulation resting state fMRI |
| title | Right inferior frontal gyrus theta-burst stimulation reduces smoking behaviors and strengthens fronto-striatal-limbic resting-state functional connectivity: a randomized crossover trial |
| title_full | Right inferior frontal gyrus theta-burst stimulation reduces smoking behaviors and strengthens fronto-striatal-limbic resting-state functional connectivity: a randomized crossover trial |
| title_fullStr | Right inferior frontal gyrus theta-burst stimulation reduces smoking behaviors and strengthens fronto-striatal-limbic resting-state functional connectivity: a randomized crossover trial |
| title_full_unstemmed | Right inferior frontal gyrus theta-burst stimulation reduces smoking behaviors and strengthens fronto-striatal-limbic resting-state functional connectivity: a randomized crossover trial |
| title_short | Right inferior frontal gyrus theta-burst stimulation reduces smoking behaviors and strengthens fronto-striatal-limbic resting-state functional connectivity: a randomized crossover trial |
| title_sort | right inferior frontal gyrus theta burst stimulation reduces smoking behaviors and strengthens fronto striatal limbic resting state functional connectivity a randomized crossover trial |
| topic | addiction smoking tobacco craving repetitive transcranial magnetic stimulation resting state fMRI |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1166912/full |
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