Association Study of CD226 and CD247 Genes Single Nucleotide Polymorphisms in Iranian Patients with Systemic Sclerosis
CD247 and CD226 play important roles in signaling of lymphocytes. Single nucleotide polymorphisms (SNPs) of genes encoding CD247 and CD226 have been associated with the risk of several autoimmune disorders. This study aimed to evaluate the possible association between CD226 and CD247 genes SNPs and...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2017-12-01
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| Series: | Iranian Journal of Allergy, Asthma and Immunology |
| Subjects: | |
| Online Access: | https://ijaai.tums.ac.ir/index.php/ijaai/article/view/1482 |
| _version_ | 1818110728031174656 |
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| author | Fatemeh Abbasi Reza Mansouri Farhad Gharibdoost Saeed Aslani Shayan Mostafaei Hoda Kavosi Shiva Poursani Soheila Sobhani Mahdi Mahmoudi |
| author_facet | Fatemeh Abbasi Reza Mansouri Farhad Gharibdoost Saeed Aslani Shayan Mostafaei Hoda Kavosi Shiva Poursani Soheila Sobhani Mahdi Mahmoudi |
| author_sort | Fatemeh Abbasi |
| collection | DOAJ |
| description | CD247 and CD226 play important roles in signaling of lymphocytes. Single nucleotide polymorphisms (SNPs) of genes encoding CD247 and CD226 have been associated with the risk of several autoimmune disorders. This study aimed to evaluate the possible association between CD226 and CD247 genes SNPs and risk of systemic sclerosis (SSc) in Iranian population. Study participants were 455 SSc patients and 455 age, sex and ethnic -matched healthy individuals. Genotyping of rs2056626 and rs763361 at CD247 and CD226 genes, respectively, was carried out using TaqMan MGB-based allelic discrimination real-time PCR. Neither alleles nor genotypes of both SNPs showed significant association with the risk of SSc. Furthermore, association analysis of the genotypes with clinical manifestations of the disease revealed that rs763361 variants were associated with the forced vital capacity (FVC) in SSc patients. Our results suggest that genetic variants of CD226 and CD247 genes may not be a contributing factor in pathogenesis of SSc in Iranian population. |
| first_indexed | 2024-12-11T02:51:45Z |
| format | Article |
| id | doaj.art-cf676d373a5e4ed1bf68f70079e4bcab |
| institution | Directory Open Access Journal |
| issn | 1735-1502 1735-5249 |
| language | English |
| last_indexed | 2024-12-11T02:51:45Z |
| publishDate | 2017-12-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Allergy, Asthma and Immunology |
| spelling | doaj.art-cf676d373a5e4ed1bf68f70079e4bcab2022-12-22T01:23:17ZengTehran University of Medical SciencesIranian Journal of Allergy, Asthma and Immunology1735-15021735-52492017-12-011661482Association Study of CD226 and CD247 Genes Single Nucleotide Polymorphisms in Iranian Patients with Systemic SclerosisFatemeh Abbasi0Reza Mansouri1Farhad Gharibdoost2Saeed Aslani3Shayan Mostafaei4Hoda Kavosi5Shiva Poursani6Soheila Sobhani7Mahdi Mahmoudi8Immunology Department, Shahid Sadoughi University of Medical Sciences, Yazd, IranImmunology Department, Shahid Sadoughi University of Medical Sciences, Yazd, IranRheumatology Research Center, Tehran University of Medical Sciences, Tehran, IranRheumatology Research Center, Tehran University of Medical Sciences, Tehran, IranRheumatology Research Center, Tehran University of Medical Sciences, Tehran, IranRheumatology Research Center, Tehran University of Medical Sciences, Tehran, IranRheumatology Research Center, Tehran University of Medical Sciences, Tehran, IranRheumatology Research Center, Tehran University of Medical Sciences, Tehran, IranRheumatology Research Center, Tehran University of Medical Sceinces, Tehran, IranCD247 and CD226 play important roles in signaling of lymphocytes. Single nucleotide polymorphisms (SNPs) of genes encoding CD247 and CD226 have been associated with the risk of several autoimmune disorders. This study aimed to evaluate the possible association between CD226 and CD247 genes SNPs and risk of systemic sclerosis (SSc) in Iranian population. Study participants were 455 SSc patients and 455 age, sex and ethnic -matched healthy individuals. Genotyping of rs2056626 and rs763361 at CD247 and CD226 genes, respectively, was carried out using TaqMan MGB-based allelic discrimination real-time PCR. Neither alleles nor genotypes of both SNPs showed significant association with the risk of SSc. Furthermore, association analysis of the genotypes with clinical manifestations of the disease revealed that rs763361 variants were associated with the forced vital capacity (FVC) in SSc patients. Our results suggest that genetic variants of CD226 and CD247 genes may not be a contributing factor in pathogenesis of SSc in Iranian population.https://ijaai.tums.ac.ir/index.php/ijaai/article/view/1482CD226CD247Single nucleotide polymorphismSystemic sclerosis |
| spellingShingle | Fatemeh Abbasi Reza Mansouri Farhad Gharibdoost Saeed Aslani Shayan Mostafaei Hoda Kavosi Shiva Poursani Soheila Sobhani Mahdi Mahmoudi Association Study of CD226 and CD247 Genes Single Nucleotide Polymorphisms in Iranian Patients with Systemic Sclerosis Iranian Journal of Allergy, Asthma and Immunology CD226 CD247 Single nucleotide polymorphism Systemic sclerosis |
| title | Association Study of CD226 and CD247 Genes Single Nucleotide Polymorphisms in Iranian Patients with Systemic Sclerosis |
| title_full | Association Study of CD226 and CD247 Genes Single Nucleotide Polymorphisms in Iranian Patients with Systemic Sclerosis |
| title_fullStr | Association Study of CD226 and CD247 Genes Single Nucleotide Polymorphisms in Iranian Patients with Systemic Sclerosis |
| title_full_unstemmed | Association Study of CD226 and CD247 Genes Single Nucleotide Polymorphisms in Iranian Patients with Systemic Sclerosis |
| title_short | Association Study of CD226 and CD247 Genes Single Nucleotide Polymorphisms in Iranian Patients with Systemic Sclerosis |
| title_sort | association study of cd226 and cd247 genes single nucleotide polymorphisms in iranian patients with systemic sclerosis |
| topic | CD226 CD247 Single nucleotide polymorphism Systemic sclerosis |
| url | https://ijaai.tums.ac.ir/index.php/ijaai/article/view/1482 |
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