Classical monocyte-derived macrophages as therapeutic targets of umbilical cord mesenchymal stem cells: comparison of intratracheal and intravenous administration in a mouse model of pulmonary fibrosis

Classical monocyte-derived macrophages as therapeutic targets of umbilical cord mesenchymal stem cells: comparison of intratracheal and intravenous administration in a mouse model of pulmonary fibrosis

Abstract Background Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease that has no cure. Although mesenchymal stem cells (MSCs) have been reported to ameliorate lung inflammation and fibrosis in mouse models, their mechanisms of action remain unknown. Therefore, we aimed to d...

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Bibliographic Details
Main Authors: Sun Mi Choi, Yosep Mo, Ji-Young Bang, Young Gyun Ko, Yoon Hae Ahn, Hye Young Kim, Jaemoon Koh, Jae-Joon Yim, Hye-Ryun Kang
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Respiratory Research
Subjects:
Pulmonary fibrosis
Monocyte
Macrophage
Mesenchymal stem cell
Bleomycin
Online Access:https://doi.org/10.1186/s12931-023-02357-x

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