The Impact of Late Secondary Hyperparathyroidism on Mortality in COVID-19 Patients: A Longitudinal Study
Background: Adverse effects of high parathormone hormone (PTH) in critical illness have been described in some studies. Objective: The relationship between high PTH levels with mortality in hospitalized patients with COVID-19 was evaluated in the present study. Methods: A total of 123 patients we...
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| Format: | Article |
| Language: | fas |
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Qazvin University of Medical Sciences & Health Services
2022-09-01
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| Series: | The Journal of Qazvin University of Medical Sciences |
| Subjects: | |
| Online Access: | https://journal.qums.ac.ir/article-1-3296-en.html |
| _version_ | 1797825417056354304 |
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| author | Sima Hashemipour Sabereh Afshar Somaieh Kiani Pouria Shahsavari Milad Badri Arefeh Ghobadi Mohammad Reza Hadizadeh Khairkhahan |
| author_facet | Sima Hashemipour Sabereh Afshar Somaieh Kiani Pouria Shahsavari Milad Badri Arefeh Ghobadi Mohammad Reza Hadizadeh Khairkhahan |
| author_sort | Sima Hashemipour |
| collection | DOAJ |
| description | Background: Adverse effects of high parathormone hormone (PTH) in critical illness have been described in some studies.
Objective: The relationship between high PTH levels with mortality in hospitalized patients with COVID-19 was evaluated in the present study.
Methods: A total of 123 patients were included in the study. The patients were evaluated in phase 1 (on admission) and phase 2 (days 4-6 of hospitalization). The patients were categorized into four groups based on the PTH status in both phases: normal PTH1/normal PTH2 (group 1), high PTH1/normal PTH2 (group 2), high PTH1/high PTH2 (group 3), and normal PTH1/high PTH2 (group 4). The multiple logistic regression analysis was performed to examine the independent association of late hyperparathyroidism with mortality. After excluding ineligible participants, 115 patients in phase 1 and 96 patients in phase 2 (days 4-6 of hospitalization) were evaluated.
Findings: The level of phase 2 PTH in non-survivors was significantly higher than in survivors (57.5±40.9 pg/mL vs. 27.6±16.2 pg/mL, P=0.001). The mortality rate was significantly higher in high-PTH groups in phase 2 compared to normal-PTH groups in this phase (50% and 42.9% in groups 3 and 4 vs. 6.6% and 18.2% in PTH groups 1 and 2, respectively, P=0.007). Late hyperparathyroidism was associated with 11.4 times higher mortality risk (95% CI: 2.3-56.1, P=0.003).
Conclusion: Late hyperparathyroidism remained a significant predictor of mortality after adjusting for the main PTH secretion modulators and disease severity. Late hyperparathyroidism is an independent and strong risk factor for mortality in COVID-19. Further studies are necessary to clarify the mechanisms involved. |
| first_indexed | 2024-03-13T10:53:43Z |
| format | Article |
| id | doaj.art-cf689f405c4a4640bd3721c94389f01d |
| institution | Directory Open Access Journal |
| issn | 1561-3666 2228-7213 |
| language | fas |
| last_indexed | 2024-03-13T10:53:43Z |
| publishDate | 2022-09-01 |
| publisher | Qazvin University of Medical Sciences & Health Services |
| record_format | Article |
| series | The Journal of Qazvin University of Medical Sciences |
| spelling | doaj.art-cf689f405c4a4640bd3721c94389f01d2023-05-17T07:04:28ZfasQazvin University of Medical Sciences & Health ServicesThe Journal of Qazvin University of Medical Sciences1561-36662228-72132022-09-01262677810.32598/JID.26.2.3The Impact of Late Secondary Hyperparathyroidism on Mortality in COVID-19 Patients: A Longitudinal StudySima HashemipourSabereh Afshar0Somaieh KianiPouria ShahsavariMilad BadriArefeh GhobadiMohammad Reza Hadizadeh KhairkhahanMetabolic Diseases Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran. Background: Adverse effects of high parathormone hormone (PTH) in critical illness have been described in some studies. Objective: The relationship between high PTH levels with mortality in hospitalized patients with COVID-19 was evaluated in the present study. Methods: A total of 123 patients were included in the study. The patients were evaluated in phase 1 (on admission) and phase 2 (days 4-6 of hospitalization). The patients were categorized into four groups based on the PTH status in both phases: normal PTH1/normal PTH2 (group 1), high PTH1/normal PTH2 (group 2), high PTH1/high PTH2 (group 3), and normal PTH1/high PTH2 (group 4). The multiple logistic regression analysis was performed to examine the independent association of late hyperparathyroidism with mortality. After excluding ineligible participants, 115 patients in phase 1 and 96 patients in phase 2 (days 4-6 of hospitalization) were evaluated. Findings: The level of phase 2 PTH in non-survivors was significantly higher than in survivors (57.5±40.9 pg/mL vs. 27.6±16.2 pg/mL, P=0.001). The mortality rate was significantly higher in high-PTH groups in phase 2 compared to normal-PTH groups in this phase (50% and 42.9% in groups 3 and 4 vs. 6.6% and 18.2% in PTH groups 1 and 2, respectively, P=0.007). Late hyperparathyroidism was associated with 11.4 times higher mortality risk (95% CI: 2.3-56.1, P=0.003). Conclusion: Late hyperparathyroidism remained a significant predictor of mortality after adjusting for the main PTH secretion modulators and disease severity. Late hyperparathyroidism is an independent and strong risk factor for mortality in COVID-19. Further studies are necessary to clarify the mechanisms involved.https://journal.qums.ac.ir/article-1-3296-en.htmlcovid-19parathormone hormone (pth) levelmortalitylate hyperparathyroidismlongitudinal study |
| spellingShingle | Sima Hashemipour Sabereh Afshar Somaieh Kiani Pouria Shahsavari Milad Badri Arefeh Ghobadi Mohammad Reza Hadizadeh Khairkhahan The Impact of Late Secondary Hyperparathyroidism on Mortality in COVID-19 Patients: A Longitudinal Study The Journal of Qazvin University of Medical Sciences covid-19 parathormone hormone (pth) level mortality late hyperparathyroidism longitudinal study |
| title | The Impact of Late Secondary Hyperparathyroidism on Mortality in COVID-19 Patients: A Longitudinal Study |
| title_full | The Impact of Late Secondary Hyperparathyroidism on Mortality in COVID-19 Patients: A Longitudinal Study |
| title_fullStr | The Impact of Late Secondary Hyperparathyroidism on Mortality in COVID-19 Patients: A Longitudinal Study |
| title_full_unstemmed | The Impact of Late Secondary Hyperparathyroidism on Mortality in COVID-19 Patients: A Longitudinal Study |
| title_short | The Impact of Late Secondary Hyperparathyroidism on Mortality in COVID-19 Patients: A Longitudinal Study |
| title_sort | impact of late secondary hyperparathyroidism on mortality in covid 19 patients a longitudinal study |
| topic | covid-19 parathormone hormone (pth) level mortality late hyperparathyroidism longitudinal study |
| url | https://journal.qums.ac.ir/article-1-3296-en.html |
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