Comparison of reversed-phase enantioselective HPLC methods for determining the enantiomeric purity of (S)-omeprazole in the presence of its related substances

Comparison of reversed-phase enantioselective HPLC methods for determining the enantiomeric purity of (S)-omeprazole in the presence of its related substances

A simple analytical high-performance liquid chromatography (HPLC) method was applied for the enantiomeric excess determination of esomeprazole ((S)-OME), the enantiopure active ingredient contained in drug products, in the presence of its potential organic impurities A-E. The enantioselective separa...

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Bibliographic Details
Main Authors: Bruno Gallinella, Rosella Ferretti, Leo Zanitti, Isabella Sestili, Antonina Mosca, Roberto Cirilli
Format: Article
Language:English
Published: Elsevier 2016-04-01
Series:Journal of Pharmaceutical Analysis
Subjects:
Chiralpak ID-3
Enantiomers
Enantioselective HPLC
Impurities
(S)-Omeprazole
Online Access:http://www.sciencedirect.com/science/article/pii/S2095177915300113

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