New early non-invasive biomarkers for acute kidney injury in critically ill full-term neonatal infants
Critically ill neonates are at high risk for acute kidney injury (AKI). Objective: to estimate the clinical and diagnostic value of urinary neutrophil gelatinase-associated lipocalin (NGAL) 2, interleukin-18 (IL-18), and kidney injury molecule-1 (KIM-1) levels in diagnosing AKI in critically ill ful...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
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Ltd. “The National Academy of Pediatric Science and Innovation”
2016-03-01
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| Series: | Rossijskij Vestnik Perinatologii i Pediatrii |
| Subjects: | |
| Online Access: | https://www.ped-perinatology.ru/jour/article/view/180 |
| Summary: | Critically ill neonates are at high risk for acute kidney injury (AKI). Objective: to estimate the clinical and diagnostic value of urinary neutrophil gelatinase-associated lipocalin (NGAL) 2, interleukin-18 (IL-18), and kidney injury molecule-1 (KIM-1) levels in diagnosing AKI in critically ill full-term newborn infants. Subjects and methods. A study group consisted of 86 critically ill full-term neonates who were divided into 2 subgroups according to their blood creatinine levels at the age of less than 2 days of life: 1) creati-nine >1,5 mg/dl (и=12) and 2) creatinine <1,5 mg/dl (и=74). A control group included 26 healthy full-term newborns. Results. The incidence of AKI was 14%. Its clinical sign was urine output less thanl, 5 ml/kg/h(/K0,001). On days 3—5 of life, Subgroup 1 showed urinary NGAL values that were twice higher than those in Subgroup 2; on days 10-14, there was a 1,5-fold decrease in this indicator, but it remained at a rather high level in the control group. On days 3-5 of life, the levels of urinary KIM-1 were thrice higher in Subgroup 1 than those in Subgroup 2; on days 18—21, the difference between them was almost 7 times higher (/K0,01). On days 3—5 of life, Subgroup 1 displayed urinary IL-18 values that were twice higher than those in Subgroup 2; on days 18—21, the difference remained at the same level (/K0,05). Conclusion. Determination of urinary NGAL, IL-18, and KIM-1 levels is recommended for the early non-invasive diagnosis of AKI in critically ill full-term neonates. Urinary NGAL and KIM-1 are markers of poor outcomes; IL-18 is a marker of the aggressive nephrotoxicity of the therapy performed. |
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| ISSN: | 1027-4065 2500-2228 |