New early non-invasive biomarkers for acute kidney injury in critically ill full-term neonatal infants
Critically ill neonates are at high risk for acute kidney injury (AKI). Objective: to estimate the clinical and diagnostic value of urinary neutrophil gelatinase-associated lipocalin (NGAL) 2, interleukin-18 (IL-18), and kidney injury molecule-1 (KIM-1) levels in diagnosing AKI in critically ill ful...
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| Format: | Article |
| Language: | Russian |
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Ltd. “The National Academy of Pediatric Science and Innovation”
2016-03-01
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| Series: | Rossijskij Vestnik Perinatologii i Pediatrii |
| Subjects: | |
| Online Access: | https://www.ped-perinatology.ru/jour/article/view/180 |
| _version_ | 1797875338169024512 |
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| author | M. A. Daminova A. I. Safina M. O. Koporulina |
| author_facet | M. A. Daminova A. I. Safina M. O. Koporulina |
| author_sort | M. A. Daminova |
| collection | DOAJ |
| description | Critically ill neonates are at high risk for acute kidney injury (AKI). Objective: to estimate the clinical and diagnostic value of urinary neutrophil gelatinase-associated lipocalin (NGAL) 2, interleukin-18 (IL-18), and kidney injury molecule-1 (KIM-1) levels in diagnosing AKI in critically ill full-term newborn infants. Subjects and methods. A study group consisted of 86 critically ill full-term neonates who were divided into 2 subgroups according to their blood creatinine levels at the age of less than 2 days of life: 1) creati-nine >1,5 mg/dl (и=12) and 2) creatinine <1,5 mg/dl (и=74). A control group included 26 healthy full-term newborns. Results. The incidence of AKI was 14%. Its clinical sign was urine output less thanl, 5 ml/kg/h(/K0,001). On days 3—5 of life, Subgroup 1 showed urinary NGAL values that were twice higher than those in Subgroup 2; on days 10-14, there was a 1,5-fold decrease in this indicator, but it remained at a rather high level in the control group. On days 3-5 of life, the levels of urinary KIM-1 were thrice higher in Subgroup 1 than those in Subgroup 2; on days 18—21, the difference between them was almost 7 times higher (/K0,01). On days 3—5 of life, Subgroup 1 displayed urinary IL-18 values that were twice higher than those in Subgroup 2; on days 18—21, the difference remained at the same level (/K0,05). Conclusion. Determination of urinary NGAL, IL-18, and KIM-1 levels is recommended for the early non-invasive diagnosis of AKI in critically ill full-term neonates. Urinary NGAL and KIM-1 are markers of poor outcomes; IL-18 is a marker of the aggressive nephrotoxicity of the therapy performed. |
| first_indexed | 2024-04-10T01:44:58Z |
| format | Article |
| id | doaj.art-cf6a6b4d4b894cdb82a3dd253a343b9d |
| institution | Directory Open Access Journal |
| issn | 1027-4065 2500-2228 |
| language | Russian |
| last_indexed | 2024-04-10T01:44:58Z |
| publishDate | 2016-03-01 |
| publisher | Ltd. “The National Academy of Pediatric Science and Innovation” |
| record_format | Article |
| series | Rossijskij Vestnik Perinatologii i Pediatrii |
| spelling | doaj.art-cf6a6b4d4b894cdb82a3dd253a343b9d2023-03-13T09:12:41ZrusLtd. “The National Academy of Pediatric Science and Innovation”Rossijskij Vestnik Perinatologii i Pediatrii1027-40652500-22282016-03-01605198205173New early non-invasive biomarkers for acute kidney injury in critically ill full-term neonatal infantsM. A. Daminova0A. I. Safina1M. O. Koporulina2Казанская государственная медицинская академияКазанская государственная медицинская академияКазанская государственная медицинская академияCritically ill neonates are at high risk for acute kidney injury (AKI). Objective: to estimate the clinical and diagnostic value of urinary neutrophil gelatinase-associated lipocalin (NGAL) 2, interleukin-18 (IL-18), and kidney injury molecule-1 (KIM-1) levels in diagnosing AKI in critically ill full-term newborn infants. Subjects and methods. A study group consisted of 86 critically ill full-term neonates who were divided into 2 subgroups according to their blood creatinine levels at the age of less than 2 days of life: 1) creati-nine >1,5 mg/dl (и=12) and 2) creatinine <1,5 mg/dl (и=74). A control group included 26 healthy full-term newborns. Results. The incidence of AKI was 14%. Its clinical sign was urine output less thanl, 5 ml/kg/h(/K0,001). On days 3—5 of life, Subgroup 1 showed urinary NGAL values that were twice higher than those in Subgroup 2; on days 10-14, there was a 1,5-fold decrease in this indicator, but it remained at a rather high level in the control group. On days 3-5 of life, the levels of urinary KIM-1 were thrice higher in Subgroup 1 than those in Subgroup 2; on days 18—21, the difference between them was almost 7 times higher (/K0,01). On days 3—5 of life, Subgroup 1 displayed urinary IL-18 values that were twice higher than those in Subgroup 2; on days 18—21, the difference remained at the same level (/K0,05). Conclusion. Determination of urinary NGAL, IL-18, and KIM-1 levels is recommended for the early non-invasive diagnosis of AKI in critically ill full-term neonates. Urinary NGAL and KIM-1 are markers of poor outcomes; IL-18 is a marker of the aggressive nephrotoxicity of the therapy performed.https://www.ped-perinatology.ru/jour/article/view/180новорожденныекритическое состояниеострое повреждение почекассоциированный с нейтрофильной желатиназой липокалин-2 (нгал)интерлейкин-18 (ил-18)молекулы повреждения почки-1 (ким-1). |
| spellingShingle | M. A. Daminova A. I. Safina M. O. Koporulina New early non-invasive biomarkers for acute kidney injury in critically ill full-term neonatal infants Rossijskij Vestnik Perinatologii i Pediatrii новорожденные критическое состояние острое повреждение почек ассоциированный с нейтрофильной желатиназой липокалин-2 (нгал) интерлейкин-18 (ил-18) молекулы повреждения почки-1 (ким-1). |
| title | New early non-invasive biomarkers for acute kidney injury in critically ill full-term neonatal infants |
| title_full | New early non-invasive biomarkers for acute kidney injury in critically ill full-term neonatal infants |
| title_fullStr | New early non-invasive biomarkers for acute kidney injury in critically ill full-term neonatal infants |
| title_full_unstemmed | New early non-invasive biomarkers for acute kidney injury in critically ill full-term neonatal infants |
| title_short | New early non-invasive biomarkers for acute kidney injury in critically ill full-term neonatal infants |
| title_sort | new early non invasive biomarkers for acute kidney injury in critically ill full term neonatal infants |
| topic | новорожденные критическое состояние острое повреждение почек ассоциированный с нейтрофильной желатиназой липокалин-2 (нгал) интерлейкин-18 (ил-18) молекулы повреждения почки-1 (ким-1). |
| url | https://www.ped-perinatology.ru/jour/article/view/180 |
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