Glial fibrillary acidic protein (GFAP): modulation by growth factors and its implication in astrocyte differentiation
Intermediate filament (IF) proteins constitute an extremely large multigene family of developmentally and tissue-regulated cytoskeleton proteins abundant in most vertebrate cell types. Astrocyte precursors of the CNS usually express vimentin as the major IF. Astrocyte maturation is followed by a swi...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Associação Brasileira de Divulgação Científica
1999-05-01
|
| Series: | Brazilian Journal of Medical and Biological Research |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000500016&tlng=en |
| _version_ | 1798014996043530240 |
|---|---|
| author | F.C.A. Gomes D. Paulin V. Moura Neto |
| author_facet | F.C.A. Gomes D. Paulin V. Moura Neto |
| author_sort | F.C.A. Gomes |
| collection | DOAJ |
| description | Intermediate filament (IF) proteins constitute an extremely large multigene family of developmentally and tissue-regulated cytoskeleton proteins abundant in most vertebrate cell types. Astrocyte precursors of the CNS usually express vimentin as the major IF. Astrocyte maturation is followed by a switch between vimentin and glial fibrillary acidic protein (GFAP) expression, with the latter being recognized as an astrocyte maturation marker. Levels of GFAP are regulated under developmental and pathological conditions. Upregulation of GFAP expression is one of the main characteristics of the astrocytic reaction commonly observed after CNS lesion. In this way, studies on GFAP regulation have been shown to be useful to understand not only brain physiology but also neurological disease. Modulators of GFAP expression include several hormones such as thyroid hormone, glucocorticoids and several growth factors such as FGF, CNTF and TGFß, among others. Studies of the GFAP gene have already identified several putative growth factor binding domains in its promoter region. Data obtained from transgenic and knockout mice have provided new insights into IF protein functions. This review highlights the most recent studies on the regulation of IF function by growth factors and hormones. |
| first_indexed | 2024-04-11T15:26:07Z |
| format | Article |
| id | doaj.art-cf6a78b5a27240609f2ffd5b575bba1f |
| institution | Directory Open Access Journal |
| issn | 1414-431X |
| language | English |
| last_indexed | 2024-04-11T15:26:07Z |
| publishDate | 1999-05-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-cf6a78b5a27240609f2ffd5b575bba1f2022-12-22T04:16:14ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research1414-431X1999-05-0132561963110.1590/S0100-879X1999000500016Glial fibrillary acidic protein (GFAP): modulation by growth factors and its implication in astrocyte differentiationF.C.A. Gomes0D. Paulin1V. Moura Neto2Instituto de Ciências BiomédicasUniversité ParisInstituto de Ciências BiomédicasIntermediate filament (IF) proteins constitute an extremely large multigene family of developmentally and tissue-regulated cytoskeleton proteins abundant in most vertebrate cell types. Astrocyte precursors of the CNS usually express vimentin as the major IF. Astrocyte maturation is followed by a switch between vimentin and glial fibrillary acidic protein (GFAP) expression, with the latter being recognized as an astrocyte maturation marker. Levels of GFAP are regulated under developmental and pathological conditions. Upregulation of GFAP expression is one of the main characteristics of the astrocytic reaction commonly observed after CNS lesion. In this way, studies on GFAP regulation have been shown to be useful to understand not only brain physiology but also neurological disease. Modulators of GFAP expression include several hormones such as thyroid hormone, glucocorticoids and several growth factors such as FGF, CNTF and TGFß, among others. Studies of the GFAP gene have already identified several putative growth factor binding domains in its promoter region. Data obtained from transgenic and knockout mice have provided new insights into IF protein functions. This review highlights the most recent studies on the regulation of IF function by growth factors and hormones.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000500016&tlng=enCNSastrocytegrowth factorsintermediate filamentsGFAPvimentinGFAP gene |
| spellingShingle | F.C.A. Gomes D. Paulin V. Moura Neto Glial fibrillary acidic protein (GFAP): modulation by growth factors and its implication in astrocyte differentiation Brazilian Journal of Medical and Biological Research CNS astrocyte growth factors intermediate filaments GFAP vimentin GFAP gene |
| title | Glial fibrillary acidic protein (GFAP): modulation by growth factors and its implication in astrocyte differentiation |
| title_full | Glial fibrillary acidic protein (GFAP): modulation by growth factors and its implication in astrocyte differentiation |
| title_fullStr | Glial fibrillary acidic protein (GFAP): modulation by growth factors and its implication in astrocyte differentiation |
| title_full_unstemmed | Glial fibrillary acidic protein (GFAP): modulation by growth factors and its implication in astrocyte differentiation |
| title_short | Glial fibrillary acidic protein (GFAP): modulation by growth factors and its implication in astrocyte differentiation |
| title_sort | glial fibrillary acidic protein gfap modulation by growth factors and its implication in astrocyte differentiation |
| topic | CNS astrocyte growth factors intermediate filaments GFAP vimentin GFAP gene |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000500016&tlng=en |
| work_keys_str_mv | AT fcagomes glialfibrillaryacidicproteingfapmodulationbygrowthfactorsanditsimplicationinastrocytedifferentiation AT dpaulin glialfibrillaryacidicproteingfapmodulationbygrowthfactorsanditsimplicationinastrocytedifferentiation AT vmouraneto glialfibrillaryacidicproteingfapmodulationbygrowthfactorsanditsimplicationinastrocytedifferentiation |