Mursamacin: a novel class of antibiotics from soil-dwelling roundworms of Central Kenya that inhibits methicillin-resistant Staphylococcus aureus [version 2; referees: 2 approved, 1 approved with reservations]
Antibiotic-resistant bacteria, also called “superbugs”, can at worst retrogress modern medicine to an era where even sore throats resulted in death. A solution is the development of novel types of antibiotics from untapped natural sources. Yet, no new class of antibiotic has been developed in clinic...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2017-08-01
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| Series: | F1000Research |
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| Online Access: | https://f1000research.com/articles/5-2431/v2 |
| _version_ | 1811209172677558272 |
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| author | Ryan Musumba Awori Peter Njenga Ng'ang'a Lorine Nanjala Nyongesa Nelson Onzere Amugune Daniel Masiga |
| author_facet | Ryan Musumba Awori Peter Njenga Ng'ang'a Lorine Nanjala Nyongesa Nelson Onzere Amugune Daniel Masiga |
| author_sort | Ryan Musumba Awori |
| collection | DOAJ |
| description | Antibiotic-resistant bacteria, also called “superbugs”, can at worst retrogress modern medicine to an era where even sore throats resulted in death. A solution is the development of novel types of antibiotics from untapped natural sources. Yet, no new class of antibiotic has been developed in clinical medicine in the last 30 years. Here, bacteria from insect-killing Steinernema roundworms found in the soils of Central Kenya were isolated and subjected to specific molecular identification. These were then assayed for production of antibiotic compounds with potential to treat methicillin-resistant Staphylococcus aureus infections. The bacteria were identified as Xenorhabdus griffiniae and produced cell free supernatants that inhibited S. aureus. Fermenting the bacteria for 4 days yielded a heat stable anti-staphylococcal class of compounds that at low concentrations also inhibited methicillin-resistant S. aureus. This class contained two major compounds whose identity remains unknown. Thus X. griffinae isolated from Steinernema roundworms in Kenya have antimicrobial potential and may herald novel and newly sourced potential medicines for treatment of the world’s most prevalent antibiotic resistant bacteria. |
| first_indexed | 2024-04-12T04:33:54Z |
| format | Article |
| id | doaj.art-cf6ad4792dc64cff8c0f7cd622283b64 |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-04-12T04:33:54Z |
| publishDate | 2017-08-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-cf6ad4792dc64cff8c0f7cd622283b642022-12-22T03:47:51ZengF1000 Research LtdF1000Research2046-14022017-08-01510.12688/f1000research.9652.213372Mursamacin: a novel class of antibiotics from soil-dwelling roundworms of Central Kenya that inhibits methicillin-resistant Staphylococcus aureus [version 2; referees: 2 approved, 1 approved with reservations]Ryan Musumba Awori0Peter Njenga Ng'ang'a1Lorine Nanjala Nyongesa2Nelson Onzere Amugune3Daniel Masiga4Trek Science, P.O Box 44947-00100, Nairobi, KenyaTrek Science, P.O Box 44947-00100, Nairobi, KenyaTrek Science, P.O Box 44947-00100, Nairobi, KenyaSchool of Biological Sciences, University of Nairobi, P. O Box 30197-00100, Nairobi, KenyaInternational Centre of Insect Physiology and Ecology, P. O. Box 30772-00100, Nairobi, KenyaAntibiotic-resistant bacteria, also called “superbugs”, can at worst retrogress modern medicine to an era where even sore throats resulted in death. A solution is the development of novel types of antibiotics from untapped natural sources. Yet, no new class of antibiotic has been developed in clinical medicine in the last 30 years. Here, bacteria from insect-killing Steinernema roundworms found in the soils of Central Kenya were isolated and subjected to specific molecular identification. These were then assayed for production of antibiotic compounds with potential to treat methicillin-resistant Staphylococcus aureus infections. The bacteria were identified as Xenorhabdus griffiniae and produced cell free supernatants that inhibited S. aureus. Fermenting the bacteria for 4 days yielded a heat stable anti-staphylococcal class of compounds that at low concentrations also inhibited methicillin-resistant S. aureus. This class contained two major compounds whose identity remains unknown. Thus X. griffinae isolated from Steinernema roundworms in Kenya have antimicrobial potential and may herald novel and newly sourced potential medicines for treatment of the world’s most prevalent antibiotic resistant bacteria.https://f1000research.com/articles/5-2431/v2Antimicrobials & Drug ResistanceEnvironmental Microbiology |
| spellingShingle | Ryan Musumba Awori Peter Njenga Ng'ang'a Lorine Nanjala Nyongesa Nelson Onzere Amugune Daniel Masiga Mursamacin: a novel class of antibiotics from soil-dwelling roundworms of Central Kenya that inhibits methicillin-resistant Staphylococcus aureus [version 2; referees: 2 approved, 1 approved with reservations] F1000Research Antimicrobials & Drug Resistance Environmental Microbiology |
| title | Mursamacin: a novel class of antibiotics from soil-dwelling roundworms of Central Kenya that inhibits methicillin-resistant Staphylococcus aureus [version 2; referees: 2 approved, 1 approved with reservations] |
| title_full | Mursamacin: a novel class of antibiotics from soil-dwelling roundworms of Central Kenya that inhibits methicillin-resistant Staphylococcus aureus [version 2; referees: 2 approved, 1 approved with reservations] |
| title_fullStr | Mursamacin: a novel class of antibiotics from soil-dwelling roundworms of Central Kenya that inhibits methicillin-resistant Staphylococcus aureus [version 2; referees: 2 approved, 1 approved with reservations] |
| title_full_unstemmed | Mursamacin: a novel class of antibiotics from soil-dwelling roundworms of Central Kenya that inhibits methicillin-resistant Staphylococcus aureus [version 2; referees: 2 approved, 1 approved with reservations] |
| title_short | Mursamacin: a novel class of antibiotics from soil-dwelling roundworms of Central Kenya that inhibits methicillin-resistant Staphylococcus aureus [version 2; referees: 2 approved, 1 approved with reservations] |
| title_sort | mursamacin a novel class of antibiotics from soil dwelling roundworms of central kenya that inhibits methicillin resistant staphylococcus aureus version 2 referees 2 approved 1 approved with reservations |
| topic | Antimicrobials & Drug Resistance Environmental Microbiology |
| url | https://f1000research.com/articles/5-2431/v2 |
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