Association of concomitant autoimmunity with the disease features and long-term treatment and health outcomes in Celiac disease
BackgroundCeliac disease (CeD) is often accompanied by other autoimmune diseases (AID). However, the association of co-existing autoimmunity with the presentation and treatment success in CeD is unclear. We investigated these issues with a large and well-defined cohort of Finnish patients.MethodsAdu...
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.1055135/full |
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| author | Riku Tauschi Riku Tauschi Anna Eurén Anna Eurén Nina Vuorela Nina Vuorela Sara Koskimaa Sara Koskimaa Heini Huhtala Katri Kaukinen Katri Kaukinen Laura Kivelä Laura Kivelä Laura Kivelä Kalle Kurppa Kalle Kurppa Kalle Kurppa Kalle Kurppa |
| author_facet | Riku Tauschi Riku Tauschi Anna Eurén Anna Eurén Nina Vuorela Nina Vuorela Sara Koskimaa Sara Koskimaa Heini Huhtala Katri Kaukinen Katri Kaukinen Laura Kivelä Laura Kivelä Laura Kivelä Kalle Kurppa Kalle Kurppa Kalle Kurppa Kalle Kurppa |
| author_sort | Riku Tauschi |
| collection | DOAJ |
| description | BackgroundCeliac disease (CeD) is often accompanied by other autoimmune diseases (AID). However, the association of co-existing autoimmunity with the presentation and treatment success in CeD is unclear. We investigated these issues with a large and well-defined cohort of Finnish patients.MethodsAdult CeD patients (n = 806) were collected from multiple heath care sites via nationwide recruitment. They were interviewed, underwent measurement of CeD autoantibodies, and filled out questionnaires to ascertain quality of life (PGWB) and gastrointestinal symptoms (GSRS) after a median of 9.7 years on a gluten-free diet. Data were supplemented retrospectively from patient records. The results were compared between CeD patients with and without a coexisting AID.ResultsAltogether 185 patients had CeD+AID and 621 had CeD only. At CeD diagnosis, patients with CeD+AID were older (median 42 vs. 36 years, p = 0.010) and had more joint symptoms (9.1 vs. 4.2%, p = 0.011), whereas the groups were comparable in sex, family history of CeD, other presenting symptoms, proportion of screen-detected subjects, and severity of duodenal lesion. During follow-up on gluten-free diet, CeD+AID patients experienced poorer general health (median score 12 vs. 14, p < 0.001) in PGWB, more overall gastrointestinal symptoms (2.1 vs. 1.9, p = 0.001), and constipation (2.0 vs. 1.7, p < 0.001) in GSRS, whereas there was no difference in histological and serological recovery, dietary adherence, use of gluten-free oats, smoking, and presence of regular follow-up.ConclusionsCo-existing AID was not significantly associated with the baseline features or with most long-term outcomes in CeD. However, the increased prevalence of gastrointestinal symptoms and reduced poorer self-perceived health during treatment indicates these patients' need for special support. |
| first_indexed | 2024-04-11T08:09:33Z |
| format | Article |
| id | doaj.art-cf6b4530948b4123a9be1cdd331a44d1 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-11T08:09:33Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-cf6b4530948b4123a9be1cdd331a44d12022-12-22T04:35:24ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-11-01910.3389/fmed.2022.10551351055135Association of concomitant autoimmunity with the disease features and long-term treatment and health outcomes in Celiac diseaseRiku Tauschi0Riku Tauschi1Anna Eurén2Anna Eurén3Nina Vuorela4Nina Vuorela5Sara Koskimaa6Sara Koskimaa7Heini Huhtala8Katri Kaukinen9Katri Kaukinen10Laura Kivelä11Laura Kivelä12Laura Kivelä13Kalle Kurppa14Kalle Kurppa15Kalle Kurppa16Kalle Kurppa17Tampere Center for Child, Adolescent and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, FinlandCeliac Disease Research Center, Faculty of Medicine and Health Technology, Tampere University, Tampere, FinlandTampere Center for Child, Adolescent and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, FinlandCeliac Disease Research Center, Faculty of Medicine and Health Technology, Tampere University, Tampere, FinlandTampere Center for Child, Adolescent and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, FinlandDepartment of Pediatrics, Tampere University Hospital, Tampere, FinlandTampere Center for Child, Adolescent and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, FinlandCeliac Disease Research Center, Faculty of Medicine and Health Technology, Tampere University, Tampere, FinlandFaculty of Social Sciences, Tampere University, Tampere, FinlandCeliac Disease Research Center, Faculty of Medicine and Health Technology, Tampere University, Tampere, FinlandDepartment of Internal Medicine, Tampere University Hospital, Tampere, FinlandTampere Center for Child, Adolescent and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, FinlandCeliac Disease Research Center, Faculty of Medicine and Health Technology, Tampere University, Tampere, FinlandChildren's Hospital, and Pediatric Research Center, University of Helsinki and Helsinki University Hospital, Helsinki, FinlandTampere Center for Child, Adolescent and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, FinlandCeliac Disease Research Center, Faculty of Medicine and Health Technology, Tampere University, Tampere, FinlandDepartment of Pediatrics, Tampere University Hospital, Tampere, FinlandThe University Consortium of Seinäjoki, Seinäjoki, FinlandBackgroundCeliac disease (CeD) is often accompanied by other autoimmune diseases (AID). However, the association of co-existing autoimmunity with the presentation and treatment success in CeD is unclear. We investigated these issues with a large and well-defined cohort of Finnish patients.MethodsAdult CeD patients (n = 806) were collected from multiple heath care sites via nationwide recruitment. They were interviewed, underwent measurement of CeD autoantibodies, and filled out questionnaires to ascertain quality of life (PGWB) and gastrointestinal symptoms (GSRS) after a median of 9.7 years on a gluten-free diet. Data were supplemented retrospectively from patient records. The results were compared between CeD patients with and without a coexisting AID.ResultsAltogether 185 patients had CeD+AID and 621 had CeD only. At CeD diagnosis, patients with CeD+AID were older (median 42 vs. 36 years, p = 0.010) and had more joint symptoms (9.1 vs. 4.2%, p = 0.011), whereas the groups were comparable in sex, family history of CeD, other presenting symptoms, proportion of screen-detected subjects, and severity of duodenal lesion. During follow-up on gluten-free diet, CeD+AID patients experienced poorer general health (median score 12 vs. 14, p < 0.001) in PGWB, more overall gastrointestinal symptoms (2.1 vs. 1.9, p = 0.001), and constipation (2.0 vs. 1.7, p < 0.001) in GSRS, whereas there was no difference in histological and serological recovery, dietary adherence, use of gluten-free oats, smoking, and presence of regular follow-up.ConclusionsCo-existing AID was not significantly associated with the baseline features or with most long-term outcomes in CeD. However, the increased prevalence of gastrointestinal symptoms and reduced poorer self-perceived health during treatment indicates these patients' need for special support.https://www.frontiersin.org/articles/10.3389/fmed.2022.1055135/fullceliac diseaseautoimmune diseaseautoimmunityquality of lifegastrointestinal symptomsgluten-free diet |
| spellingShingle | Riku Tauschi Riku Tauschi Anna Eurén Anna Eurén Nina Vuorela Nina Vuorela Sara Koskimaa Sara Koskimaa Heini Huhtala Katri Kaukinen Katri Kaukinen Laura Kivelä Laura Kivelä Laura Kivelä Kalle Kurppa Kalle Kurppa Kalle Kurppa Kalle Kurppa Association of concomitant autoimmunity with the disease features and long-term treatment and health outcomes in Celiac disease Frontiers in Medicine celiac disease autoimmune disease autoimmunity quality of life gastrointestinal symptoms gluten-free diet |
| title | Association of concomitant autoimmunity with the disease features and long-term treatment and health outcomes in Celiac disease |
| title_full | Association of concomitant autoimmunity with the disease features and long-term treatment and health outcomes in Celiac disease |
| title_fullStr | Association of concomitant autoimmunity with the disease features and long-term treatment and health outcomes in Celiac disease |
| title_full_unstemmed | Association of concomitant autoimmunity with the disease features and long-term treatment and health outcomes in Celiac disease |
| title_short | Association of concomitant autoimmunity with the disease features and long-term treatment and health outcomes in Celiac disease |
| title_sort | association of concomitant autoimmunity with the disease features and long term treatment and health outcomes in celiac disease |
| topic | celiac disease autoimmune disease autoimmunity quality of life gastrointestinal symptoms gluten-free diet |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.1055135/full |
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