Allergic Colitis in Infants Related to Cow’s Milk: Clinical Characteristics, Pathologic Changes, and Immunologic Findings
Allergic colitis (AC) is an inflammatory condition characterized by eosinophils infiltrating the colonic wall. It can be a benign and/or severe illness among gastrointestinal diseases in infants. Methods: We report five infants who, since January 2009, in whom AC under fibrotic endoscopic examinatio...
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| Format: | Article |
| Language: | English |
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Elsevier
2013-02-01
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| Series: | Pediatrics and Neonatology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1875957212001817 |
| _version_ | 1818159229979066368 |
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| author | Man-Chun Yu Chia-Lun Tsai Yao-Jong Yang Sing-San Yang Li-Hui Wang Chung-Ta Lee Ren-Long Jan Jiu-Yao Wang |
| author_facet | Man-Chun Yu Chia-Lun Tsai Yao-Jong Yang Sing-San Yang Li-Hui Wang Chung-Ta Lee Ren-Long Jan Jiu-Yao Wang |
| author_sort | Man-Chun Yu |
| collection | DOAJ |
| description | Allergic colitis (AC) is an inflammatory condition characterized by eosinophils infiltrating the colonic wall. It can be a benign and/or severe illness among gastrointestinal diseases in infants.
Methods: We report five infants who, since January 2009, in whom AC under fibrotic endoscopic examinations has been diagnosed. The criterion for histopathologic diagnosis of AC in this study was five or more eosinophils per high-power field. Patients’ clinical symptoms, pathologic findings, and immunologic studies, such as specific antibodies against component of cow’s milk protein, were compared with those of allergic children without AC and those of nonatopic control children.
Results: Histopathologic examinations of biopsy specimens revealed acute inflammation with characteristic eosinophilic infiltration of lamina propria (5–15 eosinophils per high-power field) in all five patients. They all had strongly positive skin prick tests against milk protein, which were not correlated with in vitro allergen-specific immunoglobulin (Ig) E levels. In contrast, there were significantly higher levels of IgE antibodies, and lower specific IgG4 and IgA levels to components and whole milk proteins in AC, as compared to control children without AC.
Conclusion: Endoscopic biopsy specimens of intestine confirm the diagnosis of AC. However, allergen skin prick test and IgE antibody to milk protein components also provide helpful diagnostic tools for this rare disease in children. |
| first_indexed | 2024-12-11T15:42:40Z |
| format | Article |
| id | doaj.art-cf6d6c27f07b4cccac871b27586c0498 |
| institution | Directory Open Access Journal |
| issn | 1875-9572 |
| language | English |
| last_indexed | 2024-12-11T15:42:40Z |
| publishDate | 2013-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatrics and Neonatology |
| spelling | doaj.art-cf6d6c27f07b4cccac871b27586c04982022-12-22T00:59:47ZengElsevierPediatrics and Neonatology1875-95722013-02-01541495510.1016/j.pedneo.2012.11.006Allergic Colitis in Infants Related to Cow’s Milk: Clinical Characteristics, Pathologic Changes, and Immunologic FindingsMan-Chun Yu0Chia-Lun Tsai1Yao-Jong Yang2Sing-San Yang3Li-Hui Wang4Chung-Ta Lee5Ren-Long Jan6Jiu-Yao Wang7Division of Allergy and Clinical Immunology, Department of Pediatrics, National Cheng Kung University Hospital, Tainan, TaiwanInstitute of Microbiology and Immunology, National Cheng Kung University Hospital, Tainan, TaiwanDivision of Allergy and Clinical Immunology, Department of Pediatrics, National Cheng Kung University Hospital, Tainan, TaiwanDivision of Allergy and Clinical Immunology, Department of Pediatrics, National Cheng Kung University Hospital, Tainan, TaiwanDivision of Allergy and Clinical Immunology, Department of Pediatrics, National Cheng Kung University Hospital, Tainan, TaiwanDepartment of Pathology, National Cheng Kung University Hospital, Tainan, TaiwanInstitute of Clinical Medicine, College of Medicine, National Cheng Kung University Hospital, Tainan, TaiwanDivision of Allergy and Clinical Immunology, Department of Pediatrics, National Cheng Kung University Hospital, Tainan, TaiwanAllergic colitis (AC) is an inflammatory condition characterized by eosinophils infiltrating the colonic wall. It can be a benign and/or severe illness among gastrointestinal diseases in infants. Methods: We report five infants who, since January 2009, in whom AC under fibrotic endoscopic examinations has been diagnosed. The criterion for histopathologic diagnosis of AC in this study was five or more eosinophils per high-power field. Patients’ clinical symptoms, pathologic findings, and immunologic studies, such as specific antibodies against component of cow’s milk protein, were compared with those of allergic children without AC and those of nonatopic control children. Results: Histopathologic examinations of biopsy specimens revealed acute inflammation with characteristic eosinophilic infiltration of lamina propria (5–15 eosinophils per high-power field) in all five patients. They all had strongly positive skin prick tests against milk protein, which were not correlated with in vitro allergen-specific immunoglobulin (Ig) E levels. In contrast, there were significantly higher levels of IgE antibodies, and lower specific IgG4 and IgA levels to components and whole milk proteins in AC, as compared to control children without AC. Conclusion: Endoscopic biopsy specimens of intestine confirm the diagnosis of AC. However, allergen skin prick test and IgE antibody to milk protein components also provide helpful diagnostic tools for this rare disease in children.http://www.sciencedirect.com/science/article/pii/S1875957212001817allergic colitisIgEIgG subclassmilk protein allergyskin prick test |
| spellingShingle | Man-Chun Yu Chia-Lun Tsai Yao-Jong Yang Sing-San Yang Li-Hui Wang Chung-Ta Lee Ren-Long Jan Jiu-Yao Wang Allergic Colitis in Infants Related to Cow’s Milk: Clinical Characteristics, Pathologic Changes, and Immunologic Findings Pediatrics and Neonatology allergic colitis IgE IgG subclass milk protein allergy skin prick test |
| title | Allergic Colitis in Infants Related to Cow’s Milk: Clinical Characteristics, Pathologic Changes, and Immunologic Findings |
| title_full | Allergic Colitis in Infants Related to Cow’s Milk: Clinical Characteristics, Pathologic Changes, and Immunologic Findings |
| title_fullStr | Allergic Colitis in Infants Related to Cow’s Milk: Clinical Characteristics, Pathologic Changes, and Immunologic Findings |
| title_full_unstemmed | Allergic Colitis in Infants Related to Cow’s Milk: Clinical Characteristics, Pathologic Changes, and Immunologic Findings |
| title_short | Allergic Colitis in Infants Related to Cow’s Milk: Clinical Characteristics, Pathologic Changes, and Immunologic Findings |
| title_sort | allergic colitis in infants related to cow s milk clinical characteristics pathologic changes and immunologic findings |
| topic | allergic colitis IgE IgG subclass milk protein allergy skin prick test |
| url | http://www.sciencedirect.com/science/article/pii/S1875957212001817 |
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