Monoclonal Antibody Development for Cancer Treatment Using the Phage Display Library Platform
Thirty-four years ago, the groundbreaking work of John McCafferty and Sir Gregory Winter in developing phage display technology revolutionized the discovery of human antibodies, paving the way for diverse applications. Since then, numerous phage-derived antibodies have been successfully developed an...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Biologics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2673-8449/4/1/5 |
| _version_ | 1827307048116682752 |
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| author | Tiantian Zhang Zhe Wang |
| author_facet | Tiantian Zhang Zhe Wang |
| author_sort | Tiantian Zhang |
| collection | DOAJ |
| description | Thirty-four years ago, the groundbreaking work of John McCafferty and Sir Gregory Winter in developing phage display technology revolutionized the discovery of human antibodies, paving the way for diverse applications. Since then, numerous phage-derived antibodies have been successfully developed and advanced into clinical studies, resulting in the approval of more than a dozen therapeutic antibodies. These antibodies have demonstrated efficacy across a spectrum of medical conditions, ranging from autoimmune diseases to various cancers. In this article, we provide an in-depth review of the development of phage display libraries as powerful platforms for therapeutic antibody discovery, elucidating the intricate procedures involved in antibody development. Additionally, we conduct a review of the current ntibody drugs for cancer treatment that have been developed using the phage display platform. Furthermore, we discuss the challenges inherent in this technology, offering insights into potential solutions to enhance crucial steps and facilitate more efficient drug discovery in the field of phage display technology. |
| first_indexed | 2024-04-24T18:32:44Z |
| format | Article |
| id | doaj.art-cf6f71978b234df6be88fd6dbd3a8483 |
| institution | Directory Open Access Journal |
| issn | 2673-8449 |
| language | English |
| last_indexed | 2024-04-24T18:32:44Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biologics |
| spelling | doaj.art-cf6f71978b234df6be88fd6dbd3a84832024-03-27T13:22:01ZengMDPI AGBiologics2673-84492024-02-0141557410.3390/biologics4010005Monoclonal Antibody Development for Cancer Treatment Using the Phage Display Library PlatformTiantian Zhang0Zhe Wang1Toni Stephenson Lymphoma Center, Department of Hematology and Hematopoietic Stem Cell Transplantation, Beckman Research Institute of City of Hope, Duarte, CA 91010, USAHigh Throughput Screening Core, Department of Share Resources, Beckman Research Institute of City of Hope, Duarte, CA 91010, USAThirty-four years ago, the groundbreaking work of John McCafferty and Sir Gregory Winter in developing phage display technology revolutionized the discovery of human antibodies, paving the way for diverse applications. Since then, numerous phage-derived antibodies have been successfully developed and advanced into clinical studies, resulting in the approval of more than a dozen therapeutic antibodies. These antibodies have demonstrated efficacy across a spectrum of medical conditions, ranging from autoimmune diseases to various cancers. In this article, we provide an in-depth review of the development of phage display libraries as powerful platforms for therapeutic antibody discovery, elucidating the intricate procedures involved in antibody development. Additionally, we conduct a review of the current ntibody drugs for cancer treatment that have been developed using the phage display platform. Furthermore, we discuss the challenges inherent in this technology, offering insights into potential solutions to enhance crucial steps and facilitate more efficient drug discovery in the field of phage display technology.https://www.mdpi.com/2673-8449/4/1/5phage display librarycancer treatmentantibody development |
| spellingShingle | Tiantian Zhang Zhe Wang Monoclonal Antibody Development for Cancer Treatment Using the Phage Display Library Platform Biologics phage display library cancer treatment antibody development |
| title | Monoclonal Antibody Development for Cancer Treatment Using the Phage Display Library Platform |
| title_full | Monoclonal Antibody Development for Cancer Treatment Using the Phage Display Library Platform |
| title_fullStr | Monoclonal Antibody Development for Cancer Treatment Using the Phage Display Library Platform |
| title_full_unstemmed | Monoclonal Antibody Development for Cancer Treatment Using the Phage Display Library Platform |
| title_short | Monoclonal Antibody Development for Cancer Treatment Using the Phage Display Library Platform |
| title_sort | monoclonal antibody development for cancer treatment using the phage display library platform |
| topic | phage display library cancer treatment antibody development |
| url | https://www.mdpi.com/2673-8449/4/1/5 |
| work_keys_str_mv | AT tiantianzhang monoclonalantibodydevelopmentforcancertreatmentusingthephagedisplaylibraryplatform AT zhewang monoclonalantibodydevelopmentforcancertreatmentusingthephagedisplaylibraryplatform |