Generation and characterization of human umbilical cord blood-derived induced pluripotent stem cells (KRIBBi005-A)
Induced pluripotent stem cells (iPSCs) hold great promise as a potential source for regenerative medicine. Umbilical cord blood (UCB) cells possess a high level of stem cells, exhibit less immune rejection, and have fewer DNA mutations and, thus, are an easily accessible and valuable cell source for...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-04-01
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| Series: | Stem Cell Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S187350612200023X |
| _version_ | 1818287628265455616 |
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| author | Hyebin Koh Xing Zhen Jieun Kim Hye-Yeong Ha Jong-Hee Lee |
| author_facet | Hyebin Koh Xing Zhen Jieun Kim Hye-Yeong Ha Jong-Hee Lee |
| author_sort | Hyebin Koh |
| collection | DOAJ |
| description | Induced pluripotent stem cells (iPSCs) hold great promise as a potential source for regenerative medicine. Umbilical cord blood (UCB) cells possess a high level of stem cells, exhibit less immune rejection, and have fewer DNA mutations and, thus, are an easily accessible and valuable cell source for iPSC generation for basic research and clinical applications. Here, we reprogrammed CD34+-UCB cells with the group O/D-negative (RhD-) blood type as a universal source for red blood cell (RBC) generation. The resulting iPSCs, with features typical of pluripotent stem cells, will further advance the development of various therapeutics, including blood transfusion. |
| first_indexed | 2024-12-13T01:43:30Z |
| format | Article |
| id | doaj.art-cf71d77773684d08813625c5ec356c11 |
| institution | Directory Open Access Journal |
| issn | 1873-5061 |
| language | English |
| last_indexed | 2024-12-13T01:43:30Z |
| publishDate | 2022-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Stem Cell Research |
| spelling | doaj.art-cf71d77773684d08813625c5ec356c112022-12-22T00:03:41ZengElsevierStem Cell Research1873-50612022-04-0160102674Generation and characterization of human umbilical cord blood-derived induced pluripotent stem cells (KRIBBi005-A)Hyebin Koh0Xing Zhen1Jieun Kim2Hye-Yeong Ha3Jong-Hee Lee4Futuristic Animal Resource & Research Center (FARRC), Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Republic of Korea; Department of Functional Genomics, KRIBB School of Bioscience, University of Science and Technology (UST), Daejeon, Republic of KoreaNational Primate Research Center (NPRC), Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Republic of Korea; Department of Nanoscience and Nanotechnology, Graduate School, Kyungpook National University, Daegu 41566, Republic of KoreaNational Primate Research Center (NPRC), Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Republic of Korea; Department of Medical Life Sciences, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaDivision of Intractable Disease Research, Korea National Institute of Health, Cheongju, Republic of KoreaNational Primate Research Center (NPRC), Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Republic of Korea; Department of Functional Genomics, KRIBB School of Bioscience, University of Science and Technology (UST), Daejeon, Republic of Korea; Corresponding author.Induced pluripotent stem cells (iPSCs) hold great promise as a potential source for regenerative medicine. Umbilical cord blood (UCB) cells possess a high level of stem cells, exhibit less immune rejection, and have fewer DNA mutations and, thus, are an easily accessible and valuable cell source for iPSC generation for basic research and clinical applications. Here, we reprogrammed CD34+-UCB cells with the group O/D-negative (RhD-) blood type as a universal source for red blood cell (RBC) generation. The resulting iPSCs, with features typical of pluripotent stem cells, will further advance the development of various therapeutics, including blood transfusion.http://www.sciencedirect.com/science/article/pii/S187350612200023X |
| spellingShingle | Hyebin Koh Xing Zhen Jieun Kim Hye-Yeong Ha Jong-Hee Lee Generation and characterization of human umbilical cord blood-derived induced pluripotent stem cells (KRIBBi005-A) Stem Cell Research |
| title | Generation and characterization of human umbilical cord blood-derived induced pluripotent stem cells (KRIBBi005-A) |
| title_full | Generation and characterization of human umbilical cord blood-derived induced pluripotent stem cells (KRIBBi005-A) |
| title_fullStr | Generation and characterization of human umbilical cord blood-derived induced pluripotent stem cells (KRIBBi005-A) |
| title_full_unstemmed | Generation and characterization of human umbilical cord blood-derived induced pluripotent stem cells (KRIBBi005-A) |
| title_short | Generation and characterization of human umbilical cord blood-derived induced pluripotent stem cells (KRIBBi005-A) |
| title_sort | generation and characterization of human umbilical cord blood derived induced pluripotent stem cells kribbi005 a |
| url | http://www.sciencedirect.com/science/article/pii/S187350612200023X |
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