Schizophrenia: A Narrative Review of Etiopathogenetic, Diagnostic and Treatment Aspects
Although schizophrenia is currently conceptualized as being characterized as a syndrome that includes a collection of signs and symptoms, there is strong evidence of heterogeneous and complex underpinned etiological, etiopathogenetic, and psychopathological mechanisms, which are still under investig...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/11/17/5040 |
| _version_ | 1797494817852227584 |
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| author | Laura Orsolini Simone Pompili Umberto Volpe |
| author_facet | Laura Orsolini Simone Pompili Umberto Volpe |
| author_sort | Laura Orsolini |
| collection | DOAJ |
| description | Although schizophrenia is currently conceptualized as being characterized as a syndrome that includes a collection of signs and symptoms, there is strong evidence of heterogeneous and complex underpinned etiological, etiopathogenetic, and psychopathological mechanisms, which are still under investigation. Therefore, the present viewpoint review is aimed at providing some insights into the recently investigated schizophrenia research fields in order to discuss the potential future research directions in schizophrenia research. The traditional schizophrenia construct and diagnosis were progressively revised and revisited, based on the recently emerging neurobiological, genetic, and epidemiological research. Moreover, innovative diagnostic and therapeutic approaches are pointed to build a new construct, allowing the development of better clinical and treatment outcomes and characterization for schizophrenic individuals, considering a more patient-centered, personalized, and tailored-based dimensional approach. Further translational studies are needed in order to integrate neurobiological, genetic, and environmental studies into clinical practice and to help clinicians and researchers to understand how to redesign a new schizophrenia construct. |
| first_indexed | 2024-03-10T01:39:45Z |
| format | Article |
| id | doaj.art-cf740acb35df4caeb0233f492b441163 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T01:39:45Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-cf740acb35df4caeb0233f492b4411632023-11-23T13:26:35ZengMDPI AGJournal of Clinical Medicine2077-03832022-08-011117504010.3390/jcm11175040Schizophrenia: A Narrative Review of Etiopathogenetic, Diagnostic and Treatment AspectsLaura Orsolini0Simone Pompili1Umberto Volpe2Unit of Clinical Psychiatry, Department of Clinical Neurosciences/Department of Experimental and Clinical Medicine (DIMSC), Polytechnic University of Marche, 60126 Ancona, ItalyUnit of Clinical Psychiatry, Department of Clinical Neurosciences/Department of Experimental and Clinical Medicine (DIMSC), Polytechnic University of Marche, 60126 Ancona, ItalyUnit of Clinical Psychiatry, Department of Clinical Neurosciences/Department of Experimental and Clinical Medicine (DIMSC), Polytechnic University of Marche, 60126 Ancona, ItalyAlthough schizophrenia is currently conceptualized as being characterized as a syndrome that includes a collection of signs and symptoms, there is strong evidence of heterogeneous and complex underpinned etiological, etiopathogenetic, and psychopathological mechanisms, which are still under investigation. Therefore, the present viewpoint review is aimed at providing some insights into the recently investigated schizophrenia research fields in order to discuss the potential future research directions in schizophrenia research. The traditional schizophrenia construct and diagnosis were progressively revised and revisited, based on the recently emerging neurobiological, genetic, and epidemiological research. Moreover, innovative diagnostic and therapeutic approaches are pointed to build a new construct, allowing the development of better clinical and treatment outcomes and characterization for schizophrenic individuals, considering a more patient-centered, personalized, and tailored-based dimensional approach. Further translational studies are needed in order to integrate neurobiological, genetic, and environmental studies into clinical practice and to help clinicians and researchers to understand how to redesign a new schizophrenia construct.https://www.mdpi.com/2077-0383/11/17/5040constructschizophreniaschizophrenia spectrumrenamingrethinkingrevising |
| spellingShingle | Laura Orsolini Simone Pompili Umberto Volpe Schizophrenia: A Narrative Review of Etiopathogenetic, Diagnostic and Treatment Aspects Journal of Clinical Medicine construct schizophrenia schizophrenia spectrum renaming rethinking revising |
| title | Schizophrenia: A Narrative Review of Etiopathogenetic, Diagnostic and Treatment Aspects |
| title_full | Schizophrenia: A Narrative Review of Etiopathogenetic, Diagnostic and Treatment Aspects |
| title_fullStr | Schizophrenia: A Narrative Review of Etiopathogenetic, Diagnostic and Treatment Aspects |
| title_full_unstemmed | Schizophrenia: A Narrative Review of Etiopathogenetic, Diagnostic and Treatment Aspects |
| title_short | Schizophrenia: A Narrative Review of Etiopathogenetic, Diagnostic and Treatment Aspects |
| title_sort | schizophrenia a narrative review of etiopathogenetic diagnostic and treatment aspects |
| topic | construct schizophrenia schizophrenia spectrum renaming rethinking revising |
| url | https://www.mdpi.com/2077-0383/11/17/5040 |
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