The angiogenic process and cancer
Angiogenesis, the growth of new capillaries from pre-existing vessels, is closely related to processes essential for the organism, which are entirely physiological, for example embryogenesis, reproductive cycle, and wound healing, and is also associated with pathological conditions such as tumor pro...
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Format: | Article |
Language: | English |
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Elfos Scientiae
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Series: | Biotecnología Aplicada |
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Online Access: | http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1027-28522009000200001&lng=en&tlng=en |
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author | Omar López Yack Magariño René Delgado |
author_facet | Omar López Yack Magariño René Delgado |
author_sort | Omar López |
collection | DOAJ |
description | Angiogenesis, the growth of new capillaries from pre-existing vessels, is closely related to processes essential for the organism, which are entirely physiological, for example embryogenesis, reproductive cycle, and wound healing, and is also associated with pathological conditions such as tumor progression, metastasis, diabetic retinopathy, hemangioma, arthritis, psoriasis and atherosclerosis, among other chronic diseases. The development of specific anti-angiogenic agents arises as an attractive therapeutic approach to treat cancer and other angiogenesis-dependent diseases. Many of these agents are being evaluated in clinical trials and have shown promising antitumor activity. This review attempts to provide a comprehensive overview of key knowledge accumulated on angiogenesis and its role in cancer, including the components of signal transduction pathways that have been explored in this process. Additionally, this review focuses on the current approaches for the discovery of new compounds that inhibit angiogenesis, emphasizing on the clinical developmental status of antiangiogenic drugs. |
first_indexed | 2024-12-12T08:55:06Z |
format | Article |
id | doaj.art-cf747e3c5c1a45fdbbbeb941ea3ef30b |
institution | Directory Open Access Journal |
issn | 1027-2852 |
language | English |
last_indexed | 2024-12-12T08:55:06Z |
publisher | Elfos Scientiae |
record_format | Article |
series | Biotecnología Aplicada |
spelling | doaj.art-cf747e3c5c1a45fdbbbeb941ea3ef30b2022-12-22T00:30:01ZengElfos ScientiaeBiotecnología Aplicada1027-2852262111116S1027-28522009000200001The angiogenic process and cancerOmar López0Yack Magariño1René Delgado2IFALCentro de Estudio para las Investigaciones y Evaluaciones BiológicasCentro Nacional Coordinador de Ensayos ClínicosAngiogenesis, the growth of new capillaries from pre-existing vessels, is closely related to processes essential for the organism, which are entirely physiological, for example embryogenesis, reproductive cycle, and wound healing, and is also associated with pathological conditions such as tumor progression, metastasis, diabetic retinopathy, hemangioma, arthritis, psoriasis and atherosclerosis, among other chronic diseases. The development of specific anti-angiogenic agents arises as an attractive therapeutic approach to treat cancer and other angiogenesis-dependent diseases. Many of these agents are being evaluated in clinical trials and have shown promising antitumor activity. This review attempts to provide a comprehensive overview of key knowledge accumulated on angiogenesis and its role in cancer, including the components of signal transduction pathways that have been explored in this process. Additionally, this review focuses on the current approaches for the discovery of new compounds that inhibit angiogenesis, emphasizing on the clinical developmental status of antiangiogenic drugs.http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1027-28522009000200001&lng=en&tlng=enangiogénesiscáncertumor |
spellingShingle | Omar López Yack Magariño René Delgado The angiogenic process and cancer Biotecnología Aplicada angiogénesis cáncer tumor |
title | The angiogenic process and cancer |
title_full | The angiogenic process and cancer |
title_fullStr | The angiogenic process and cancer |
title_full_unstemmed | The angiogenic process and cancer |
title_short | The angiogenic process and cancer |
title_sort | angiogenic process and cancer |
topic | angiogénesis cáncer tumor |
url | http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1027-28522009000200001&lng=en&tlng=en |
work_keys_str_mv | AT omarlopez theangiogenicprocessandcancer AT yackmagarino theangiogenicprocessandcancer AT renedelgado theangiogenicprocessandcancer AT omarlopez angiogenicprocessandcancer AT yackmagarino angiogenicprocessandcancer AT renedelgado angiogenicprocessandcancer |