The angiogenic process and cancer

Angiogenesis, the growth of new capillaries from pre-existing vessels, is closely related to processes essential for the organism, which are entirely physiological, for example embryogenesis, reproductive cycle, and wound healing, and is also associated with pathological conditions such as tumor pro...

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Main Authors: Omar López, Yack Magariño, René Delgado
Format: Article
Language:English
Published: Elfos Scientiae
Series:Biotecnología Aplicada
Subjects:
Online Access:http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1027-28522009000200001&lng=en&tlng=en
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author Omar López
Yack Magariño
René Delgado
author_facet Omar López
Yack Magariño
René Delgado
author_sort Omar López
collection DOAJ
description Angiogenesis, the growth of new capillaries from pre-existing vessels, is closely related to processes essential for the organism, which are entirely physiological, for example embryogenesis, reproductive cycle, and wound healing, and is also associated with pathological conditions such as tumor progression, metastasis, diabetic retinopathy, hemangioma, arthritis, psoriasis and atherosclerosis, among other chronic diseases. The development of specific anti-angiogenic agents arises as an attractive therapeutic approach to treat cancer and other angiogenesis-dependent diseases. Many of these agents are being evaluated in clinical trials and have shown promising antitumor activity. This review attempts to provide a comprehensive overview of key knowledge accumulated on angiogenesis and its role in cancer, including the components of signal transduction pathways that have been explored in this process. Additionally, this review focuses on the current approaches for the discovery of new compounds that inhibit angiogenesis, emphasizing on the clinical developmental status of antiangiogenic drugs.
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spelling doaj.art-cf747e3c5c1a45fdbbbeb941ea3ef30b2022-12-22T00:30:01ZengElfos ScientiaeBiotecnología Aplicada1027-2852262111116S1027-28522009000200001The angiogenic process and cancerOmar López0Yack Magariño1René Delgado2IFALCentro de Estudio para las Investigaciones y Evaluaciones BiológicasCentro Nacional Coordinador de Ensayos ClínicosAngiogenesis, the growth of new capillaries from pre-existing vessels, is closely related to processes essential for the organism, which are entirely physiological, for example embryogenesis, reproductive cycle, and wound healing, and is also associated with pathological conditions such as tumor progression, metastasis, diabetic retinopathy, hemangioma, arthritis, psoriasis and atherosclerosis, among other chronic diseases. The development of specific anti-angiogenic agents arises as an attractive therapeutic approach to treat cancer and other angiogenesis-dependent diseases. Many of these agents are being evaluated in clinical trials and have shown promising antitumor activity. This review attempts to provide a comprehensive overview of key knowledge accumulated on angiogenesis and its role in cancer, including the components of signal transduction pathways that have been explored in this process. Additionally, this review focuses on the current approaches for the discovery of new compounds that inhibit angiogenesis, emphasizing on the clinical developmental status of antiangiogenic drugs.http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1027-28522009000200001&lng=en&tlng=enangiogénesiscáncertumor
spellingShingle Omar López
Yack Magariño
René Delgado
The angiogenic process and cancer
Biotecnología Aplicada
angiogénesis
cáncer
tumor
title The angiogenic process and cancer
title_full The angiogenic process and cancer
title_fullStr The angiogenic process and cancer
title_full_unstemmed The angiogenic process and cancer
title_short The angiogenic process and cancer
title_sort angiogenic process and cancer
topic angiogénesis
cáncer
tumor
url http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1027-28522009000200001&lng=en&tlng=en
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