Thalidomide Suppresses Angiogenesis Through the Signal Transducer and Activator of Transcription 3/SP4 Signaling Pathway in the Peritoneal Membrane

Thalidomide Suppresses Angiogenesis Through the Signal Transducer and Activator of Transcription 3/SP4 Signaling Pathway in the Peritoneal Membrane

Peritoneal angiogenesis is the key pathophysiological factor that limits peritoneal ultrafiltration during peritoneal dialysis (PD) in uremic patients. Thalidomide has been confirmed to inhibit angiogenesis by inhibiting the secretion of vascular endothelial growth factor (VEGF), but the exact mecha...

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Bibliographic Details
Main Authors: Nan Zhu, Ling Wang, Huimin Guo, Jieshuang Jia, Lijie Gu, Xuan Wang, Man Yang, Haochen Guan, Weijie Yuan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Physiology
Subjects:
peritoneal dialysis
angiogenesis
thalidomide
STAT3
SP4
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.712147/full

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