<i>Salmonella</i> as a Promising Curative Tool against Cancer
Bacteria-mediated cancer therapy has become a topic of interest under the broad umbrella of oncotherapy. Among many bacterial species, <i>Salmonella</i> remains at the forefront due to its ability to localize and proliferate inside tumor microenvironments and often suppress tumor growth....
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/14/10/2100 |
| _version_ | 1797470406227001344 |
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| author | Ram Prasad Aganja Chandran Sivasankar Amal Senevirathne John Hwa Lee |
| author_facet | Ram Prasad Aganja Chandran Sivasankar Amal Senevirathne John Hwa Lee |
| author_sort | Ram Prasad Aganja |
| collection | DOAJ |
| description | Bacteria-mediated cancer therapy has become a topic of interest under the broad umbrella of oncotherapy. Among many bacterial species, <i>Salmonella</i> remains at the forefront due to its ability to localize and proliferate inside tumor microenvironments and often suppress tumor growth. <i>Salmonella</i> Typhimurium is one of the most promising mediators, with engineering plasticity and cancer specificity. It can be used to deliver toxins that induce cell death in cancer cells specifically, and also as a cancer-specific instrument for immunotherapy by delivering tumor antigens and exposing the tumor environment to the host immune system. <i>Salmonella</i> can be used to deliver prodrug converting enzymes unambiguously against cancer. Though positive responses in <i>Salmonella</i><i>-</i>mediated cancer treatments are still at a preliminary level, they have paved the way for developing combinatorial therapy with conventional chemotherapy, radiotherapy, and surgery, and can be used synergistically to combat multi-drug resistant and higher-stage cancers. With this background, <i>Salmonella</i><i>-</i>mediated cancer therapy was approved for clinical trials by U.S. Food and Drug Administration, but the results were not satisfactory and more pre-clinical investigation is needed. This review summarizes the recent advancements in <i>Salmonella</i><i>-</i>mediated oncotherapy in the fight against cancer. The present article emphasizes the demand for <i>Salmonella</i> mutants with high stringency toward cancer and with amenable elements of safety by virulence deletions. |
| first_indexed | 2024-03-09T19:35:55Z |
| format | Article |
| id | doaj.art-cf74ebf2be5c4193947e0d8b4da646b5 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T19:35:55Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-cf74ebf2be5c4193947e0d8b4da646b52023-11-24T01:55:55ZengMDPI AGPharmaceutics1999-49232022-10-011410210010.3390/pharmaceutics14102100<i>Salmonella</i> as a Promising Curative Tool against CancerRam Prasad Aganja0Chandran Sivasankar1Amal Senevirathne2John Hwa Lee3Department of Veterinary Public Health, College of Veterinary Medicine, Jeonbuk National University, Iksan 54596, KoreaDepartment of Veterinary Public Health, College of Veterinary Medicine, Jeonbuk National University, Iksan 54596, KoreaDepartment of Preventive Medicine, College of Veterinary Medicine, Chungnam National University, Daejeon 34134, KoreaDepartment of Veterinary Public Health, College of Veterinary Medicine, Jeonbuk National University, Iksan 54596, KoreaBacteria-mediated cancer therapy has become a topic of interest under the broad umbrella of oncotherapy. Among many bacterial species, <i>Salmonella</i> remains at the forefront due to its ability to localize and proliferate inside tumor microenvironments and often suppress tumor growth. <i>Salmonella</i> Typhimurium is one of the most promising mediators, with engineering plasticity and cancer specificity. It can be used to deliver toxins that induce cell death in cancer cells specifically, and also as a cancer-specific instrument for immunotherapy by delivering tumor antigens and exposing the tumor environment to the host immune system. <i>Salmonella</i> can be used to deliver prodrug converting enzymes unambiguously against cancer. Though positive responses in <i>Salmonella</i><i>-</i>mediated cancer treatments are still at a preliminary level, they have paved the way for developing combinatorial therapy with conventional chemotherapy, radiotherapy, and surgery, and can be used synergistically to combat multi-drug resistant and higher-stage cancers. With this background, <i>Salmonella</i><i>-</i>mediated cancer therapy was approved for clinical trials by U.S. Food and Drug Administration, but the results were not satisfactory and more pre-clinical investigation is needed. This review summarizes the recent advancements in <i>Salmonella</i><i>-</i>mediated oncotherapy in the fight against cancer. The present article emphasizes the demand for <i>Salmonella</i> mutants with high stringency toward cancer and with amenable elements of safety by virulence deletions.https://www.mdpi.com/1999-4923/14/10/2100<i>Salmonella</i><i>Salmonella</i>-mediated cancer therapycombination therapyanti-tumor mechanism |
| spellingShingle | Ram Prasad Aganja Chandran Sivasankar Amal Senevirathne John Hwa Lee <i>Salmonella</i> as a Promising Curative Tool against Cancer Pharmaceutics <i>Salmonella</i> <i>Salmonella</i>-mediated cancer therapy combination therapy anti-tumor mechanism |
| title | <i>Salmonella</i> as a Promising Curative Tool against Cancer |
| title_full | <i>Salmonella</i> as a Promising Curative Tool against Cancer |
| title_fullStr | <i>Salmonella</i> as a Promising Curative Tool against Cancer |
| title_full_unstemmed | <i>Salmonella</i> as a Promising Curative Tool against Cancer |
| title_short | <i>Salmonella</i> as a Promising Curative Tool against Cancer |
| title_sort | i salmonella i as a promising curative tool against cancer |
| topic | <i>Salmonella</i> <i>Salmonella</i>-mediated cancer therapy combination therapy anti-tumor mechanism |
| url | https://www.mdpi.com/1999-4923/14/10/2100 |
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