The hedgehog pathway in hematopoiesis and hematological malignancy

The hedgehog pathway in hematopoiesis and hematological malignancy

The Hedgehog (HH) pathway is a promising therapeutic target in hematological malignancies. Activation of the pathway has been tied to greater chances of relapse and poorer outcomes in several hematological malignancies and inhibiting the pathway has improved outcomes in several clinical trials. One...

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Bibliographic Details
Main Authors: Tucker Lemos, Akil Merchant
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Oncology
Subjects:
hematological malignancy
glasdegib
smoothened inhibition
Gli3
GLI1
acute myeloid leukemia
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.960943/full

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