Acute Hyponatremia Complicated with Seizure after Adjuvant Chemotherapy with Cyclophosphamide and Epirubicin in a Breast Cancer Patient
Cyclophosphamide is a widely-used alkylating agent with cytotoxic effects, as well as an immunosuppressive agent. In the past, life-threatening hyponatremia had been reported as a rare complication induced by both high-dose and low-dose cyclophosphamide. We presented a breast cancer patient who had...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2015-06-01
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| Series: | Journal of Cancer Research and Practice |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2311300616300726 |
| _version_ | 1817997664453656576 |
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| author | Yun-Chu Lin Dwan-Ying Chang |
| author_facet | Yun-Chu Lin Dwan-Ying Chang |
| author_sort | Yun-Chu Lin |
| collection | DOAJ |
| description | Cyclophosphamide is a widely-used alkylating agent with cytotoxic effects, as well as an immunosuppressive agent. In the past, life-threatening hyponatremia had been reported as a rare complication induced by both high-dose and low-dose cyclophosphamide. We presented a breast cancer patient who had generalized seizure after the second cycle of adjuvant cyclophosphamide plus epirubicin, as her serum sodium concentration dropped from 134 mmol/L to 115 mmol/L within one day. Complete recovery was achieved after her hyponatremia was corrected and we further successfully completed two additional cycles of cyclophosphamide. Clinicians should always keep in mind this rare but severe adverse effect of cyclophosphamide, in order to make the correct diagnosis and provide prompt medical management. |
| first_indexed | 2024-04-14T02:41:44Z |
| format | Article |
| id | doaj.art-cf7a257f74f344bf9ef2239be7dead9c |
| institution | Directory Open Access Journal |
| issn | 2311-3006 |
| language | English |
| last_indexed | 2024-04-14T02:41:44Z |
| publishDate | 2015-06-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Cancer Research and Practice |
| spelling | doaj.art-cf7a257f74f344bf9ef2239be7dead9c2022-12-22T02:16:56ZengWolters Kluwer Medknow PublicationsJournal of Cancer Research and Practice2311-30062015-06-012215716110.6323/JCRP.2015.2.2.07Acute Hyponatremia Complicated with Seizure after Adjuvant Chemotherapy with Cyclophosphamide and Epirubicin in a Breast Cancer PatientYun-Chu Lin0Dwan-Ying Chang1Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, TaiwanDepartment of Oncology, National Taiwan University Hospital, Taipei, TaiwanCyclophosphamide is a widely-used alkylating agent with cytotoxic effects, as well as an immunosuppressive agent. In the past, life-threatening hyponatremia had been reported as a rare complication induced by both high-dose and low-dose cyclophosphamide. We presented a breast cancer patient who had generalized seizure after the second cycle of adjuvant cyclophosphamide plus epirubicin, as her serum sodium concentration dropped from 134 mmol/L to 115 mmol/L within one day. Complete recovery was achieved after her hyponatremia was corrected and we further successfully completed two additional cycles of cyclophosphamide. Clinicians should always keep in mind this rare but severe adverse effect of cyclophosphamide, in order to make the correct diagnosis and provide prompt medical management.http://www.sciencedirect.com/science/article/pii/S2311300616300726cyclophosphamidehyponatremiaseizure |
| spellingShingle | Yun-Chu Lin Dwan-Ying Chang Acute Hyponatremia Complicated with Seizure after Adjuvant Chemotherapy with Cyclophosphamide and Epirubicin in a Breast Cancer Patient Journal of Cancer Research and Practice cyclophosphamide hyponatremia seizure |
| title | Acute Hyponatremia Complicated with Seizure after Adjuvant Chemotherapy with Cyclophosphamide and Epirubicin in a Breast Cancer Patient |
| title_full | Acute Hyponatremia Complicated with Seizure after Adjuvant Chemotherapy with Cyclophosphamide and Epirubicin in a Breast Cancer Patient |
| title_fullStr | Acute Hyponatremia Complicated with Seizure after Adjuvant Chemotherapy with Cyclophosphamide and Epirubicin in a Breast Cancer Patient |
| title_full_unstemmed | Acute Hyponatremia Complicated with Seizure after Adjuvant Chemotherapy with Cyclophosphamide and Epirubicin in a Breast Cancer Patient |
| title_short | Acute Hyponatremia Complicated with Seizure after Adjuvant Chemotherapy with Cyclophosphamide and Epirubicin in a Breast Cancer Patient |
| title_sort | acute hyponatremia complicated with seizure after adjuvant chemotherapy with cyclophosphamide and epirubicin in a breast cancer patient |
| topic | cyclophosphamide hyponatremia seizure |
| url | http://www.sciencedirect.com/science/article/pii/S2311300616300726 |
| work_keys_str_mv | AT yunchulin acutehyponatremiacomplicatedwithseizureafteradjuvantchemotherapywithcyclophosphamideandepirubicininabreastcancerpatient AT dwanyingchang acutehyponatremiacomplicatedwithseizureafteradjuvantchemotherapywithcyclophosphamideandepirubicininabreastcancerpatient |