Heightened presence of inflammatory mediators in the cerebrospinal fluid of patients with trigeminal neuralgia
Abstract. Introduction:. Trigeminal neuralgia (TN) is a chronic, debilitating facial pain disease causing stabbing pain attacks in the sensory distribution of the trigeminal nerve. The underlying pathophysiology of TN is incompletely understood, although microstructural abnormalities consistent with...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer
2023-12-01
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| Series: | PAIN Reports |
| Online Access: | http://journals.lww.com/painrpts/fulltext/10.1097/PR9.0000000000001117 |
| _version_ | 1797375003916763136 |
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| author | Curtis Ostertag Timothy N. Friedman Michael B. Keough Bradley J. Kerr Tejas Sankar |
| author_facet | Curtis Ostertag Timothy N. Friedman Michael B. Keough Bradley J. Kerr Tejas Sankar |
| author_sort | Curtis Ostertag |
| collection | DOAJ |
| description | Abstract. Introduction:. Trigeminal neuralgia (TN) is a chronic, debilitating facial pain disease causing stabbing pain attacks in the sensory distribution of the trigeminal nerve. The underlying pathophysiology of TN is incompletely understood, although microstructural abnormalities consistent with focal demyelination of the trigeminal nerve root have been shown in patients with TN. Studies of the cerebrospinal fluid (CSF) in patients with TN suggest an increased prevalence of inflammatory mediators, potentially implicating neuroinflammation in the pathophysiology of TN, as it has been implicated in other chronic pain conditions.
Objectives:. This study aimed to further assess the inflammatory profile of CSF in TN.
Methods:. Cerebrospinal fluid was collected from 8 medically refractory patients with TN undergoing microvascular decompression surgery and 4 pain-free controls (2 with hemifacial spasm; 2 with normal pressure hydrocephalus). Cerebrospinal fluid was collected from the cerebellopontine angle cistern intraoperatively in the patients with TN. Inflammatory profiles of CSF samples were analyzed using a 71-plex cytokine and chemokine multiplex assay.
Results:. Ten inflammatory markers were found to be significantly higher in TN CSF, and no analytes were significantly lower. Elevated factors can be classified into pro-inflammatory cytokines (IL-9, IL-18, and IL-33), chemokines (RANTES and ENA-78), the tumor necrosis factor superfamily (TRAIL and sCD40L), and growth factors (EGF, PDGF-AB/BB, and FGF-2).
Conclusion:. This study further supports the notion that neuroinflammation is present in TN, and that multiple molecular pathways are implicated. |
| first_indexed | 2024-03-08T19:15:55Z |
| format | Article |
| id | doaj.art-cf7a41355983480c800fb377afef527e |
| institution | Directory Open Access Journal |
| issn | 2471-2531 |
| language | English |
| last_indexed | 2024-03-08T19:15:55Z |
| publishDate | 2023-12-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | PAIN Reports |
| spelling | doaj.art-cf7a41355983480c800fb377afef527e2023-12-27T06:53:25ZengWolters KluwerPAIN Reports2471-25312023-12-0186e111710.1097/PR9.0000000000001117202312000-00021Heightened presence of inflammatory mediators in the cerebrospinal fluid of patients with trigeminal neuralgiaCurtis Ostertag0Timothy N. Friedman1Michael B. Keough2Bradley J. Kerr3Tejas Sankar4a Cumming School of Medicine, University of Calgary, Calgary, AB, Canadab Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canadac Division of Neurosurgery, Department of Surgery, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canadab Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canadab Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, CanadaAbstract. Introduction:. Trigeminal neuralgia (TN) is a chronic, debilitating facial pain disease causing stabbing pain attacks in the sensory distribution of the trigeminal nerve. The underlying pathophysiology of TN is incompletely understood, although microstructural abnormalities consistent with focal demyelination of the trigeminal nerve root have been shown in patients with TN. Studies of the cerebrospinal fluid (CSF) in patients with TN suggest an increased prevalence of inflammatory mediators, potentially implicating neuroinflammation in the pathophysiology of TN, as it has been implicated in other chronic pain conditions. Objectives:. This study aimed to further assess the inflammatory profile of CSF in TN. Methods:. Cerebrospinal fluid was collected from 8 medically refractory patients with TN undergoing microvascular decompression surgery and 4 pain-free controls (2 with hemifacial spasm; 2 with normal pressure hydrocephalus). Cerebrospinal fluid was collected from the cerebellopontine angle cistern intraoperatively in the patients with TN. Inflammatory profiles of CSF samples were analyzed using a 71-plex cytokine and chemokine multiplex assay. Results:. Ten inflammatory markers were found to be significantly higher in TN CSF, and no analytes were significantly lower. Elevated factors can be classified into pro-inflammatory cytokines (IL-9, IL-18, and IL-33), chemokines (RANTES and ENA-78), the tumor necrosis factor superfamily (TRAIL and sCD40L), and growth factors (EGF, PDGF-AB/BB, and FGF-2). Conclusion:. This study further supports the notion that neuroinflammation is present in TN, and that multiple molecular pathways are implicated.http://journals.lww.com/painrpts/fulltext/10.1097/PR9.0000000000001117 |
| spellingShingle | Curtis Ostertag Timothy N. Friedman Michael B. Keough Bradley J. Kerr Tejas Sankar Heightened presence of inflammatory mediators in the cerebrospinal fluid of patients with trigeminal neuralgia PAIN Reports |
| title | Heightened presence of inflammatory mediators in the cerebrospinal fluid of patients with trigeminal neuralgia |
| title_full | Heightened presence of inflammatory mediators in the cerebrospinal fluid of patients with trigeminal neuralgia |
| title_fullStr | Heightened presence of inflammatory mediators in the cerebrospinal fluid of patients with trigeminal neuralgia |
| title_full_unstemmed | Heightened presence of inflammatory mediators in the cerebrospinal fluid of patients with trigeminal neuralgia |
| title_short | Heightened presence of inflammatory mediators in the cerebrospinal fluid of patients with trigeminal neuralgia |
| title_sort | heightened presence of inflammatory mediators in the cerebrospinal fluid of patients with trigeminal neuralgia |
| url | http://journals.lww.com/painrpts/fulltext/10.1097/PR9.0000000000001117 |
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