Gastroprotective Effects of Inulae Flos on HCl/Ethanol-Induced Gastric Ulcers in Rats
Inulae Flos, the flower of <i>Inula britannica</i> L., is used as a dietary supplement, beverage, and medicine in East Asia. In this study, we evaluated the gastroprotective effects of Inulae Flos extract (IFE) against gastric mucosal lesions induced by hydrochloric acid (HCl)/ethanol in...
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MDPI AG
2020-11-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/23/5623 |
| _version_ | 1797546263976083456 |
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| author | Young-Sik Kim Ji Hyeon Lee Jungbin Song Hocheol Kim |
| author_facet | Young-Sik Kim Ji Hyeon Lee Jungbin Song Hocheol Kim |
| author_sort | Young-Sik Kim |
| collection | DOAJ |
| description | Inulae Flos, the flower of <i>Inula britannica</i> L., is used as a dietary supplement, beverage, and medicine in East Asia. In this study, we evaluated the gastroprotective effects of Inulae Flos extract (IFE) against gastric mucosal lesions induced by hydrochloric acid (HCl)/ethanol in rats and explored its potential mechanisms by measuring antioxidant enzyme activity, mucus secretion, and prostaglandin E<sub>2</sub> (PGE<sub>2</sub>) levels. Pretreatment with IFE at doses of 100 and 300 mg/kg significantly inhibited gastric lesions in HCl/ethanol-treated rats. IFE increased the activities of superoxide dismutase and catalase and the levels of glutathione and PGE<sub>2</sub> in gastric tissues. The administration of IFE also significantly increased the gastric wall mucus contents in HCl/ethanol-induced gastric lesions. These findings suggest that IFE has gastroprotective effects against HCl/ethanol-induced gastric lesions and exerts these effects through increased antioxidant levels and gastric mucus secretion. Inulae Flos may be a promising agent for the prevention and treatment of gastritis and gastric ulcers. |
| first_indexed | 2024-03-10T14:27:34Z |
| format | Article |
| id | doaj.art-cf7b0aeb2e0d489e800b0b25f2235a60 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T14:27:34Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
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| series | Molecules |
| spelling | doaj.art-cf7b0aeb2e0d489e800b0b25f2235a602023-11-20T22:52:44ZengMDPI AGMolecules1420-30492020-11-012523562310.3390/molecules25235623Gastroprotective Effects of Inulae Flos on HCl/Ethanol-Induced Gastric Ulcers in RatsYoung-Sik Kim0Ji Hyeon Lee1Jungbin Song2Hocheol Kim3Department of Herbal Pharmacology, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, KoreaDepartment of Herbal Pharmacology, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, KoreaDepartment of Herbal Pharmacology, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, KoreaDepartment of Herbal Pharmacology, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, KoreaInulae Flos, the flower of <i>Inula britannica</i> L., is used as a dietary supplement, beverage, and medicine in East Asia. In this study, we evaluated the gastroprotective effects of Inulae Flos extract (IFE) against gastric mucosal lesions induced by hydrochloric acid (HCl)/ethanol in rats and explored its potential mechanisms by measuring antioxidant enzyme activity, mucus secretion, and prostaglandin E<sub>2</sub> (PGE<sub>2</sub>) levels. Pretreatment with IFE at doses of 100 and 300 mg/kg significantly inhibited gastric lesions in HCl/ethanol-treated rats. IFE increased the activities of superoxide dismutase and catalase and the levels of glutathione and PGE<sub>2</sub> in gastric tissues. The administration of IFE also significantly increased the gastric wall mucus contents in HCl/ethanol-induced gastric lesions. These findings suggest that IFE has gastroprotective effects against HCl/ethanol-induced gastric lesions and exerts these effects through increased antioxidant levels and gastric mucus secretion. Inulae Flos may be a promising agent for the prevention and treatment of gastritis and gastric ulcers.https://www.mdpi.com/1420-3049/25/23/5623<i>Inula britannica</i>gastric ulcergastritisgastric wall mucusantioxidantprostaglandin E<sub>2</sub> |
| spellingShingle | Young-Sik Kim Ji Hyeon Lee Jungbin Song Hocheol Kim Gastroprotective Effects of Inulae Flos on HCl/Ethanol-Induced Gastric Ulcers in Rats Molecules <i>Inula britannica</i> gastric ulcer gastritis gastric wall mucus antioxidant prostaglandin E<sub>2</sub> |
| title | Gastroprotective Effects of Inulae Flos on HCl/Ethanol-Induced Gastric Ulcers in Rats |
| title_full | Gastroprotective Effects of Inulae Flos on HCl/Ethanol-Induced Gastric Ulcers in Rats |
| title_fullStr | Gastroprotective Effects of Inulae Flos on HCl/Ethanol-Induced Gastric Ulcers in Rats |
| title_full_unstemmed | Gastroprotective Effects of Inulae Flos on HCl/Ethanol-Induced Gastric Ulcers in Rats |
| title_short | Gastroprotective Effects of Inulae Flos on HCl/Ethanol-Induced Gastric Ulcers in Rats |
| title_sort | gastroprotective effects of inulae flos on hcl ethanol induced gastric ulcers in rats |
| topic | <i>Inula britannica</i> gastric ulcer gastritis gastric wall mucus antioxidant prostaglandin E<sub>2</sub> |
| url | https://www.mdpi.com/1420-3049/25/23/5623 |
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