Malignant Skin Cancer Excision in Combined Therapy with Electro-Chemotherapy and Dermal Substitute
Squamous cell carcinoma (SCC) is the second most common malignancy skin cancer. It is characterized by abnormal, accelerated growth of squamous cells (SCs). SCC occurs when DNA damage from exposure to ultraviolet radiation or other damaging agents trigger abnormal changes in the SCs, presenting as p...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Current Oncology |
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| Online Access: | https://www.mdpi.com/1718-7729/28/3/160 |
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| author | Barbara De Angelis Alberto Balzani Alessia Pagnotta Eleonora Tati Fabrizio Orlandi Margarida Fernandes Lopes Morais D’Autilio Valerio Cervelli Pietro Gentile |
| author_facet | Barbara De Angelis Alberto Balzani Alessia Pagnotta Eleonora Tati Fabrizio Orlandi Margarida Fernandes Lopes Morais D’Autilio Valerio Cervelli Pietro Gentile |
| author_sort | Barbara De Angelis |
| collection | DOAJ |
| description | Squamous cell carcinoma (SCC) is the second most common malignancy skin cancer. It is characterized by abnormal, accelerated growth of squamous cells (SCs). SCC occurs when DNA damage from exposure to ultraviolet radiation or other damaging agents trigger abnormal changes in the SCs, presenting as painless lesions on areas of high sun exposure, such as the dorsum of the hand and upper extremity. For most skin SCC, the surgical excision alone is standard practice. However, recent efforts in new treatment strategies have involved around adjuvant or concomitant electrochemotherapy (ECT). ECT is a non-thermal tumor ablation modality, safe and effective on any type of solid tumor. An 87-year-old patient affected by hand SCC with invasion of deep structures including tendons was treated with neoadjuvant intra-tumoral ECT sessions followed by a selective surgical removal and reconstruction of the substance loss with collagen dermal template (CDT). Two neoadjuvant intra-tumoral ECT procedures, at distance of 3 months, with the aim to reduce the tumor size before a selective surgery, were performed. This study shows that combined surgical selective excision with ECT and CDT is a valid technique for the extended-deep dorsal hand tumor lesions reconstruction. |
| first_indexed | 2024-03-10T08:01:25Z |
| format | Article |
| id | doaj.art-cf7c03bd3c1244f78b1879b18d2aa8f6 |
| institution | Directory Open Access Journal |
| issn | 1198-0052 1718-7729 |
| language | English |
| last_indexed | 2024-03-10T08:01:25Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj.art-cf7c03bd3c1244f78b1879b18d2aa8f62023-11-22T11:26:55ZengMDPI AGCurrent Oncology1198-00521718-77292021-05-012831718172710.3390/curroncol28030160Malignant Skin Cancer Excision in Combined Therapy with Electro-Chemotherapy and Dermal SubstituteBarbara De Angelis0Alberto Balzani1Alessia Pagnotta2Eleonora Tati3Fabrizio Orlandi4Margarida Fernandes Lopes Morais D’Autilio5Valerio Cervelli6Pietro Gentile7Surgical Science Department, Medical School, University “Tor Vergata”, 00133 Rome, ItalyPlastic and Reconstructive Surgery, Complex Operative Unit, “Policlinico Casilino”, 00169 Rome, ItalyHand and Microsurgery Unit, Jewish Hospital, 00148 Rome, ItalyPlastic and Reconstructive Surgery, Complex Operative Unit, “Policlinico Casilino”, 00169 Rome, ItalyPlastic and Reconstructive Surgery, Complex Operative Unit, “Policlinico Casilino”, 00169 Rome, ItalyPlastic and Reconstructive Surgery, Complex Operative Unit, “Policlinico Casilino”, 00169 Rome, ItalySurgical Science Department, Medical School, University “Tor Vergata”, 00133 Rome, ItalySurgical Science Department, Medical School, University “Tor Vergata”, 00133 Rome, ItalySquamous cell carcinoma (SCC) is the second most common malignancy skin cancer. It is characterized by abnormal, accelerated growth of squamous cells (SCs). SCC occurs when DNA damage from exposure to ultraviolet radiation or other damaging agents trigger abnormal changes in the SCs, presenting as painless lesions on areas of high sun exposure, such as the dorsum of the hand and upper extremity. For most skin SCC, the surgical excision alone is standard practice. However, recent efforts in new treatment strategies have involved around adjuvant or concomitant electrochemotherapy (ECT). ECT is a non-thermal tumor ablation modality, safe and effective on any type of solid tumor. An 87-year-old patient affected by hand SCC with invasion of deep structures including tendons was treated with neoadjuvant intra-tumoral ECT sessions followed by a selective surgical removal and reconstruction of the substance loss with collagen dermal template (CDT). Two neoadjuvant intra-tumoral ECT procedures, at distance of 3 months, with the aim to reduce the tumor size before a selective surgery, were performed. This study shows that combined surgical selective excision with ECT and CDT is a valid technique for the extended-deep dorsal hand tumor lesions reconstruction.https://www.mdpi.com/1718-7729/28/3/160squamous cell carcinomamalignant skin tumor treatmentelectrochemotherapydermal substituteskin cancer treatment |
| spellingShingle | Barbara De Angelis Alberto Balzani Alessia Pagnotta Eleonora Tati Fabrizio Orlandi Margarida Fernandes Lopes Morais D’Autilio Valerio Cervelli Pietro Gentile Malignant Skin Cancer Excision in Combined Therapy with Electro-Chemotherapy and Dermal Substitute Current Oncology squamous cell carcinoma malignant skin tumor treatment electrochemotherapy dermal substitute skin cancer treatment |
| title | Malignant Skin Cancer Excision in Combined Therapy with Electro-Chemotherapy and Dermal Substitute |
| title_full | Malignant Skin Cancer Excision in Combined Therapy with Electro-Chemotherapy and Dermal Substitute |
| title_fullStr | Malignant Skin Cancer Excision in Combined Therapy with Electro-Chemotherapy and Dermal Substitute |
| title_full_unstemmed | Malignant Skin Cancer Excision in Combined Therapy with Electro-Chemotherapy and Dermal Substitute |
| title_short | Malignant Skin Cancer Excision in Combined Therapy with Electro-Chemotherapy and Dermal Substitute |
| title_sort | malignant skin cancer excision in combined therapy with electro chemotherapy and dermal substitute |
| topic | squamous cell carcinoma malignant skin tumor treatment electrochemotherapy dermal substitute skin cancer treatment |
| url | https://www.mdpi.com/1718-7729/28/3/160 |
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