DNA oxidative damage in pregnant women upon exposure to conventional and alternative phthalates
Exposure to alternative phthalates and related health effects in pregnant women are rarely reported. Nineteen phthalate metabolites and a DNA oxidative damage biomarker 8-hydroxy-2′-deoxyguanosine (8-OHdG) were determined in urine samples of pregnant women recruited in South China. The detection fre...
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| Format: | Article |
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Elsevier
2021-11-01
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| Series: | Environment International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412021003688 |
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| author | Ying-Jie Zhang Liu-Hong Wu Fei Wang Liang-Ying Liu Eddy Y. Zeng Ying Guo |
| author_facet | Ying-Jie Zhang Liu-Hong Wu Fei Wang Liang-Ying Liu Eddy Y. Zeng Ying Guo |
| author_sort | Ying-Jie Zhang |
| collection | DOAJ |
| description | Exposure to alternative phthalates and related health effects in pregnant women are rarely reported. Nineteen phthalate metabolites and a DNA oxidative damage biomarker 8-hydroxy-2′-deoxyguanosine (8-OHdG) were determined in urine samples of pregnant women recruited in South China. The detection frequencies and concentration of selected alternative phthalates, i.e., diisononyl phthalate (DiNP), diisodecyl phthalate (DiDP) and di-(2-propylheptyl) phthalate (DPHP) were lower than those of conventional phthalates. However, mono-(6-hydroxy-2-propylheptyl) phthalate, a metabolite of DPHP, was detected in 70% of urine samples (median: 0.13 ng/mL). The estimated daily intakes of conventional plasticizers, including dimethyl phthalate, di-n-butyl phthalate, diisobutyl phthalate and di-(2-ethylhexyl) phthalate (median range: 1.0–3.0 μg/kg_bw/day) were significantly higher than those of DiNP (0.08 μg/kg_bw/day) and DPHP (0.03 μg/kg_bw/day) (p < 0.05). Approximately 24% of pregnant women were at high risk when cumulative risk from exposure to several phthalates was considered. The concentrations of phthalate metabolites and urinary 8-OHdG were significantly correlated with each other (r = 0.206–0.772, p < 0.01), which were further conformed by multiple linear regression analysis (β = 0.168–0.639, p < 0.01). In addition, conventional phthalates were more strongly correlated with 8-OHdG than alternative phthalates (i.e., DiNP, DPHP), partly suggesting the relatively smaller health effects of alternatives due to their low exposure doses and toxicities. These findings suggested that alternative phthalates have entered the human body from consumer products in the study area, and exposure-related risk of DNA oxidative stress was comparatively lower. |
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| institution | Directory Open Access Journal |
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| language | English |
| last_indexed | 2024-12-21T22:24:19Z |
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| spelling | doaj.art-cf7c82eebdb0434095c30afecf1c49022022-12-21T18:48:16ZengElsevierEnvironment International0160-41202021-11-01156106743DNA oxidative damage in pregnant women upon exposure to conventional and alternative phthalatesYing-Jie Zhang0Liu-Hong Wu1Fei Wang2Liang-Ying Liu3Eddy Y. Zeng4Ying Guo5Guangdong Key Laboratory of Environmental Pollution and Health, School of Environment, Jinan University, Guangzhou 510632, ChinaGuangdong Key Laboratory of Environmental Pollution and Health, School of Environment, Jinan University, Guangzhou 510632, ChinaGuangdong Key Laboratory of Environmental Pollution and Health, School of Environment, Jinan University, Guangzhou 510632, ChinaGuangdong Key Laboratory of Environmental Pollution and Health, School of Environment, Jinan University, Guangzhou 510632, ChinaGuangdong Key Laboratory of Environmental Pollution and Health, School of Environment, Jinan University, Guangzhou 510632, ChinaCorresponding author.; Guangdong Key Laboratory of Environmental Pollution and Health, School of Environment, Jinan University, Guangzhou 510632, ChinaExposure to alternative phthalates and related health effects in pregnant women are rarely reported. Nineteen phthalate metabolites and a DNA oxidative damage biomarker 8-hydroxy-2′-deoxyguanosine (8-OHdG) were determined in urine samples of pregnant women recruited in South China. The detection frequencies and concentration of selected alternative phthalates, i.e., diisononyl phthalate (DiNP), diisodecyl phthalate (DiDP) and di-(2-propylheptyl) phthalate (DPHP) were lower than those of conventional phthalates. However, mono-(6-hydroxy-2-propylheptyl) phthalate, a metabolite of DPHP, was detected in 70% of urine samples (median: 0.13 ng/mL). The estimated daily intakes of conventional plasticizers, including dimethyl phthalate, di-n-butyl phthalate, diisobutyl phthalate and di-(2-ethylhexyl) phthalate (median range: 1.0–3.0 μg/kg_bw/day) were significantly higher than those of DiNP (0.08 μg/kg_bw/day) and DPHP (0.03 μg/kg_bw/day) (p < 0.05). Approximately 24% of pregnant women were at high risk when cumulative risk from exposure to several phthalates was considered. The concentrations of phthalate metabolites and urinary 8-OHdG were significantly correlated with each other (r = 0.206–0.772, p < 0.01), which were further conformed by multiple linear regression analysis (β = 0.168–0.639, p < 0.01). In addition, conventional phthalates were more strongly correlated with 8-OHdG than alternative phthalates (i.e., DiNP, DPHP), partly suggesting the relatively smaller health effects of alternatives due to their low exposure doses and toxicities. These findings suggested that alternative phthalates have entered the human body from consumer products in the study area, and exposure-related risk of DNA oxidative stress was comparatively lower.http://www.sciencedirect.com/science/article/pii/S0160412021003688Phthalate alternativesPregnant womenInternal exposureOxidative stress8-OHdGDPHP |
| spellingShingle | Ying-Jie Zhang Liu-Hong Wu Fei Wang Liang-Ying Liu Eddy Y. Zeng Ying Guo DNA oxidative damage in pregnant women upon exposure to conventional and alternative phthalates Environment International Phthalate alternatives Pregnant women Internal exposure Oxidative stress 8-OHdG DPHP |
| title | DNA oxidative damage in pregnant women upon exposure to conventional and alternative phthalates |
| title_full | DNA oxidative damage in pregnant women upon exposure to conventional and alternative phthalates |
| title_fullStr | DNA oxidative damage in pregnant women upon exposure to conventional and alternative phthalates |
| title_full_unstemmed | DNA oxidative damage in pregnant women upon exposure to conventional and alternative phthalates |
| title_short | DNA oxidative damage in pregnant women upon exposure to conventional and alternative phthalates |
| title_sort | dna oxidative damage in pregnant women upon exposure to conventional and alternative phthalates |
| topic | Phthalate alternatives Pregnant women Internal exposure Oxidative stress 8-OHdG DPHP |
| url | http://www.sciencedirect.com/science/article/pii/S0160412021003688 |
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