Could Temperamental Features Modulate Participation in Clinical Trials?
The prodromal stages of Alzheimer’s disease (AD) are the primary focus of research aimed at slowing disease progression. This study explores the influence of affective temperament on the motivation of people with mild cognitive impairment (MCI) and subjective cognitive decline (SCD) to participate i...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-01-01
|
| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/12/3/1121 |
| _version_ | 1797624086315139072 |
|---|---|
| author | Simona Cintoli Camilla Elefante Claudia Radicchi Giulio Emilio Brancati Silvia Bacciardi Joyce Bonaccorsi Gabriele Siciliano Icro Maremmani Giulio Perugi Gloria Tognoni |
| author_facet | Simona Cintoli Camilla Elefante Claudia Radicchi Giulio Emilio Brancati Silvia Bacciardi Joyce Bonaccorsi Gabriele Siciliano Icro Maremmani Giulio Perugi Gloria Tognoni |
| author_sort | Simona Cintoli |
| collection | DOAJ |
| description | The prodromal stages of Alzheimer’s disease (AD) are the primary focus of research aimed at slowing disease progression. This study explores the influence of affective temperament on the motivation of people with mild cognitive impairment (MCI) and subjective cognitive decline (SCD) to participate in clinical trials. One hundred four subjects with MCI and SCD were screened for participation in pharmacological and non-pharmacological trials. Affective temperament was assessed based on the Temperament Evaluation of the Memphis, Pisa, Paris and San Diego (TEMPS) scale. Demographic variables and temperament subscales scores were compared between MCI and SCD patients and among patients participating in the pharmacological trial, the non-pharmacological trial and refusing participation. Twenty-one subjects consented to participate in the pharmacological trial, seventy consented to the non-pharmacological trial and thirteen refused to participate in any trial. Patients with SCD had greater education and more depressive temperamental traits than those with MCI. While older age, higher education and anxious temperament were negatively associated with participation in the pharmacological trial, irritable temperamental positively predicted pharmacological trial participation. In conclusion, temperamental features may affect the willingness of patients with MCI and SCD to take part in clinical trials and, especially, the choice to participate in pharmacological studies. |
| first_indexed | 2024-03-11T09:38:21Z |
| format | Article |
| id | doaj.art-cf7ca4070d4a4f48903b40eea0262771 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T09:38:21Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-cf7ca4070d4a4f48903b40eea02627712023-11-16T17:12:02ZengMDPI AGJournal of Clinical Medicine2077-03832023-01-01123112110.3390/jcm12031121Could Temperamental Features Modulate Participation in Clinical Trials?Simona Cintoli0Camilla Elefante1Claudia Radicchi2Giulio Emilio Brancati3Silvia Bacciardi4Joyce Bonaccorsi5Gabriele Siciliano6Icro Maremmani7Giulio Perugi8Gloria Tognoni9Neurology Unit, Santa Chiara University Hospital, 56126 Pisa, ItalyPsychiatry Unit, Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, ItalyInstitute of Neuroscience, National Research Council, 56124 Pisa, ItalyPsychiatry Unit, Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, ItalyDepartment of Psychiatry, North-Western Tuscany Region NHS Local Health Unit, Versilia Zone, 55049 Viareggio, ItalyNeurology Unit, Santa Chiara University Hospital, 56126 Pisa, ItalyNeurology Unit, Santa Chiara University Hospital, 56126 Pisa, ItalyPsychiatry Unit, Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, ItalyPsychiatry Unit, Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, ItalyNeurology Unit, Santa Chiara University Hospital, 56126 Pisa, ItalyThe prodromal stages of Alzheimer’s disease (AD) are the primary focus of research aimed at slowing disease progression. This study explores the influence of affective temperament on the motivation of people with mild cognitive impairment (MCI) and subjective cognitive decline (SCD) to participate in clinical trials. One hundred four subjects with MCI and SCD were screened for participation in pharmacological and non-pharmacological trials. Affective temperament was assessed based on the Temperament Evaluation of the Memphis, Pisa, Paris and San Diego (TEMPS) scale. Demographic variables and temperament subscales scores were compared between MCI and SCD patients and among patients participating in the pharmacological trial, the non-pharmacological trial and refusing participation. Twenty-one subjects consented to participate in the pharmacological trial, seventy consented to the non-pharmacological trial and thirteen refused to participate in any trial. Patients with SCD had greater education and more depressive temperamental traits than those with MCI. While older age, higher education and anxious temperament were negatively associated with participation in the pharmacological trial, irritable temperamental positively predicted pharmacological trial participation. In conclusion, temperamental features may affect the willingness of patients with MCI and SCD to take part in clinical trials and, especially, the choice to participate in pharmacological studies.https://www.mdpi.com/2077-0383/12/3/1121Alzheimer’ diseasemild cognitive impairmentsubjective cognitive declinetemperamentclinical trialsrecruitment |
| spellingShingle | Simona Cintoli Camilla Elefante Claudia Radicchi Giulio Emilio Brancati Silvia Bacciardi Joyce Bonaccorsi Gabriele Siciliano Icro Maremmani Giulio Perugi Gloria Tognoni Could Temperamental Features Modulate Participation in Clinical Trials? Journal of Clinical Medicine Alzheimer’ disease mild cognitive impairment subjective cognitive decline temperament clinical trials recruitment |
| title | Could Temperamental Features Modulate Participation in Clinical Trials? |
| title_full | Could Temperamental Features Modulate Participation in Clinical Trials? |
| title_fullStr | Could Temperamental Features Modulate Participation in Clinical Trials? |
| title_full_unstemmed | Could Temperamental Features Modulate Participation in Clinical Trials? |
| title_short | Could Temperamental Features Modulate Participation in Clinical Trials? |
| title_sort | could temperamental features modulate participation in clinical trials |
| topic | Alzheimer’ disease mild cognitive impairment subjective cognitive decline temperament clinical trials recruitment |
| url | https://www.mdpi.com/2077-0383/12/3/1121 |
| work_keys_str_mv | AT simonacintoli couldtemperamentalfeaturesmodulateparticipationinclinicaltrials AT camillaelefante couldtemperamentalfeaturesmodulateparticipationinclinicaltrials AT claudiaradicchi couldtemperamentalfeaturesmodulateparticipationinclinicaltrials AT giulioemiliobrancati couldtemperamentalfeaturesmodulateparticipationinclinicaltrials AT silviabacciardi couldtemperamentalfeaturesmodulateparticipationinclinicaltrials AT joycebonaccorsi couldtemperamentalfeaturesmodulateparticipationinclinicaltrials AT gabrielesiciliano couldtemperamentalfeaturesmodulateparticipationinclinicaltrials AT icromaremmani couldtemperamentalfeaturesmodulateparticipationinclinicaltrials AT giulioperugi couldtemperamentalfeaturesmodulateparticipationinclinicaltrials AT gloriatognoni couldtemperamentalfeaturesmodulateparticipationinclinicaltrials |