The Hypothesis of the COVID-19 Role in Acute kidney Injury: A Literatures Review
Coronavirus disease 2019 (COVID-2019) is a viral infection that mainly causes pulmonary infection but mortality usually occurred in patients have comorbidities, such as chronic kidney disease (CKD) that accounts for over 20% of mortalities, morbid obesity, immunosuppression, diabetes mellitus, hyper...
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| Format: | Article |
| Language: | English |
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Urology Research Center
2020-08-01
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| Series: | Translational Research in Urology |
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| Online Access: | https://www.transresurology.com/article_119469.html |
| _version_ | 1818427485232037888 |
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| author | Abdolreza Mohammadi Seyed Mohammad Kazem Aghamir |
| author_facet | Abdolreza Mohammadi Seyed Mohammad Kazem Aghamir |
| author_sort | Abdolreza Mohammadi |
| collection | DOAJ |
| description | Coronavirus disease 2019 (COVID-2019) is a viral infection that mainly causes pulmonary infection but mortality usually occurred in patients have comorbidities, such as chronic kidney disease (CKD) that accounts for over 20% of mortalities, morbid obesity, immunosuppression, diabetes mellitus, hypertension, and cancer. Also, the incidence of acute kidney failure reported 5-10% in outpatient series and up to 50% in patients that need to be admitted to the intensive care unit. It is important to know that acute kidney injury (AKI) is associated with increased mortality, so this essay is going to review possible mechanisms that result in AKI. Based on the multifactorial mechanism of AKI, we should have considered probable causes of AKI and act in a stepwise manner to tackle these mechanisms and improve the ultimate prognosis of patients. Although most of the measures are supportive, in some patients such as severely ill cases cytokine storm may be attributed to the severity of symptoms, so immunomodulatory treatments could be considered to decrease AKI and consequently mortality. Among hypotheses that propose AKI; pre-renal and direct renal involvement by a virus are discussed in detail. |
| first_indexed | 2024-12-14T14:46:28Z |
| format | Article |
| id | doaj.art-cf81115348454dfba66ef1cea24b8a40 |
| institution | Directory Open Access Journal |
| issn | 2717-042X |
| language | English |
| last_indexed | 2024-12-14T14:46:28Z |
| publishDate | 2020-08-01 |
| publisher | Urology Research Center |
| record_format | Article |
| series | Translational Research in Urology |
| spelling | doaj.art-cf81115348454dfba66ef1cea24b8a402022-12-21T22:57:16ZengUrology Research CenterTranslational Research in Urology2717-042X2020-08-0123747810.22034/TRU.2020.255389.1040The Hypothesis of the COVID-19 Role in Acute kidney Injury: A Literatures ReviewAbdolreza Mohammadi 0Seyed Mohammad Kazem Aghamir1https://orcid.org/0000-0003-1611-0362Urology Research Center, Tehran University of Medical Sciences, Tehran, IranUrology Research Center, Tehran University of Medical Sciences, Tehran, IranCoronavirus disease 2019 (COVID-2019) is a viral infection that mainly causes pulmonary infection but mortality usually occurred in patients have comorbidities, such as chronic kidney disease (CKD) that accounts for over 20% of mortalities, morbid obesity, immunosuppression, diabetes mellitus, hypertension, and cancer. Also, the incidence of acute kidney failure reported 5-10% in outpatient series and up to 50% in patients that need to be admitted to the intensive care unit. It is important to know that acute kidney injury (AKI) is associated with increased mortality, so this essay is going to review possible mechanisms that result in AKI. Based on the multifactorial mechanism of AKI, we should have considered probable causes of AKI and act in a stepwise manner to tackle these mechanisms and improve the ultimate prognosis of patients. Although most of the measures are supportive, in some patients such as severely ill cases cytokine storm may be attributed to the severity of symptoms, so immunomodulatory treatments could be considered to decrease AKI and consequently mortality. Among hypotheses that propose AKI; pre-renal and direct renal involvement by a virus are discussed in detail.https://www.transresurology.com/article_119469.htmlacute kidney injuryacute tubular necrosischronic kidney diseasecovid-2019infection |
| spellingShingle | Abdolreza Mohammadi Seyed Mohammad Kazem Aghamir The Hypothesis of the COVID-19 Role in Acute kidney Injury: A Literatures Review Translational Research in Urology acute kidney injury acute tubular necrosis chronic kidney disease covid-2019 infection |
| title | The Hypothesis of the COVID-19 Role in Acute kidney Injury: A Literatures Review |
| title_full | The Hypothesis of the COVID-19 Role in Acute kidney Injury: A Literatures Review |
| title_fullStr | The Hypothesis of the COVID-19 Role in Acute kidney Injury: A Literatures Review |
| title_full_unstemmed | The Hypothesis of the COVID-19 Role in Acute kidney Injury: A Literatures Review |
| title_short | The Hypothesis of the COVID-19 Role in Acute kidney Injury: A Literatures Review |
| title_sort | hypothesis of the covid 19 role in acute kidney injury a literatures review |
| topic | acute kidney injury acute tubular necrosis chronic kidney disease covid-2019 infection |
| url | https://www.transresurology.com/article_119469.html |
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