Antipollution skin protection – a new paradigm and its demonstration on two active compounds
Meital Portugal-Cohen,1,2 Miriam Oron,1,2 Dror Cohen,1–3 Zeevi Ma’or1,2 1AHAVA Dead Sea Laboratories, Lod, Israel; 2The Dead Sea Laboratory for Skin Biochemistry and Biotechnology, Dead Sea and Arava Science Center, Masada, Israel; 3The Institute for Drug Research, The Hebrew Un...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2017-05-01
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| Series: | Clinical, Cosmetic and Investigational Dermatology |
| Subjects: | |
| Online Access: | https://www.dovepress.com/antipollution-skin-protection-a-new-paradigm-and-its-demonstration-on--peer-reviewed-article-CCID |
| _version_ | 1818384092086927360 |
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| author | Portugal-Cohen M Oron M Cohen D Ma'or Z |
| author_facet | Portugal-Cohen M Oron M Cohen D Ma'or Z |
| author_sort | Portugal-Cohen M |
| collection | DOAJ |
| description | Meital Portugal-Cohen,1,2 Miriam Oron,1,2 Dror Cohen,1–3 Zeevi Ma’or1,2 1AHAVA Dead Sea Laboratories, Lod, Israel; 2The Dead Sea Laboratory for Skin Biochemistry and Biotechnology, Dead Sea and Arava Science Center, Masada, Israel; 3The Institute for Drug Research, The Hebrew University of Jerusalem, Jerusalem, Israel Background: Urban pollution is a major source of concern for human health and is a complex of many environmental factors. The topical exposure to pollution activates cutaneous stress.Objective: In this study, we tested the antipollution protection of two active components: Dead Sea minerals (Dead Sea mineral-rich water [DSW]) and anionic polysaccharide (PolluStop® [PS]).Materials and methods: Two representative pollution models were studied using reconstructed epidermis: 1) mixture of pollutants (MOP) containing heavy metals and atmospheric particulate matter and 2) ozone exposure. DSW and PS were topically applied alone or in combination, and their protection against pollution was assessed by testing the levels of the inflammation markers interleukin 1α (IL-1α) and prostaglandin E2 (PGE2).Results: MOP exposure induced IL-1α release, which was attenuated following pre-application with DSW and PS alone or in combination. Ozone exposure induced IL-1α and PGE2 release. Pre-application with DSW or PS alone did not inhibit IL-1α and PGE2 overproduction. Only when DSW and PS were mixed together, inhibition of these inflammatory markers was observed.Conclusion: The observations reveal the potential use of active agents in combination for a selective mode of protection from urban pollution. This is because many active materials cannot solely provide a broad protection against different types of pollutants. This strategy might be beneficial for future antipollution regimen formulated in both pharmaceutical and cosmetic products. Keywords: urban pollution, dermal exposure, inflammation, oxidation, alternative skin models, antipollution activity |
| first_indexed | 2024-12-14T03:16:45Z |
| format | Article |
| id | doaj.art-cf818009dbeb48019a6fe931521d02a7 |
| institution | Directory Open Access Journal |
| issn | 1178-7015 |
| language | English |
| last_indexed | 2024-12-14T03:16:45Z |
| publishDate | 2017-05-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical, Cosmetic and Investigational Dermatology |
| spelling | doaj.art-cf818009dbeb48019a6fe931521d02a72022-12-21T23:19:08ZengDove Medical PressClinical, Cosmetic and Investigational Dermatology1178-70152017-05-01Volume 1018519332893Antipollution skin protection – a new paradigm and its demonstration on two active compoundsPortugal-Cohen MOron MCohen DMa'or ZMeital Portugal-Cohen,1,2 Miriam Oron,1,2 Dror Cohen,1–3 Zeevi Ma’or1,2 1AHAVA Dead Sea Laboratories, Lod, Israel; 2The Dead Sea Laboratory for Skin Biochemistry and Biotechnology, Dead Sea and Arava Science Center, Masada, Israel; 3The Institute for Drug Research, The Hebrew University of Jerusalem, Jerusalem, Israel Background: Urban pollution is a major source of concern for human health and is a complex of many environmental factors. The topical exposure to pollution activates cutaneous stress.Objective: In this study, we tested the antipollution protection of two active components: Dead Sea minerals (Dead Sea mineral-rich water [DSW]) and anionic polysaccharide (PolluStop® [PS]).Materials and methods: Two representative pollution models were studied using reconstructed epidermis: 1) mixture of pollutants (MOP) containing heavy metals and atmospheric particulate matter and 2) ozone exposure. DSW and PS were topically applied alone or in combination, and their protection against pollution was assessed by testing the levels of the inflammation markers interleukin 1α (IL-1α) and prostaglandin E2 (PGE2).Results: MOP exposure induced IL-1α release, which was attenuated following pre-application with DSW and PS alone or in combination. Ozone exposure induced IL-1α and PGE2 release. Pre-application with DSW or PS alone did not inhibit IL-1α and PGE2 overproduction. Only when DSW and PS were mixed together, inhibition of these inflammatory markers was observed.Conclusion: The observations reveal the potential use of active agents in combination for a selective mode of protection from urban pollution. This is because many active materials cannot solely provide a broad protection against different types of pollutants. This strategy might be beneficial for future antipollution regimen formulated in both pharmaceutical and cosmetic products. Keywords: urban pollution, dermal exposure, inflammation, oxidation, alternative skin models, antipollution activityhttps://www.dovepress.com/antipollution-skin-protection-a-new-paradigm-and-its-demonstration-on--peer-reviewed-article-CCIDurban pollutiondermal exposureinflammationoxidationalternative skin modelsanti-pollution activity |
| spellingShingle | Portugal-Cohen M Oron M Cohen D Ma'or Z Antipollution skin protection – a new paradigm and its demonstration on two active compounds Clinical, Cosmetic and Investigational Dermatology urban pollution dermal exposure inflammation oxidation alternative skin models anti-pollution activity |
| title | Antipollution skin protection – a new paradigm and its demonstration on two active compounds |
| title_full | Antipollution skin protection – a new paradigm and its demonstration on two active compounds |
| title_fullStr | Antipollution skin protection – a new paradigm and its demonstration on two active compounds |
| title_full_unstemmed | Antipollution skin protection – a new paradigm and its demonstration on two active compounds |
| title_short | Antipollution skin protection – a new paradigm and its demonstration on two active compounds |
| title_sort | antipollution skin protection ndash a new paradigm and its demonstration on two active compounds |
| topic | urban pollution dermal exposure inflammation oxidation alternative skin models anti-pollution activity |
| url | https://www.dovepress.com/antipollution-skin-protection-a-new-paradigm-and-its-demonstration-on--peer-reviewed-article-CCID |
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