Serum Albumin Levels as a Potential Marker for the Predictive and Prognostic Factor in Sudden Sensorineural Hearing Loss: A Prospective Cohort Study
Objectives: As a common otology emergency, sudden sensorineural hearing loss (SSNHL) has a great impact on quality of life. The diagnosis and treatment of SSNHL remain challenging. This study aims to identify and investigate the association of liver functions with SSNHL.Methods: A total of 135 SSNHL...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-10-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2021.747561/full |
| _version_ | 1818585844732133376 |
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| author | Zhong Zheng Zhong Zheng Chengqi Liu Chengqi Liu Ying Shen Ying Shen Liang Xia Liang Xia Lili Xiao Lili Xiao Yuanyuan Sun Yuanyuan Sun Hui Wang Hui Wang Zhengnong Chen Zhengnong Chen Yaqin Wu Yaqin Wu Haibo Shi Haibo Shi Yanmei Feng Yanmei Feng Shankai Yin Shankai Yin |
| author_facet | Zhong Zheng Zhong Zheng Chengqi Liu Chengqi Liu Ying Shen Ying Shen Liang Xia Liang Xia Lili Xiao Lili Xiao Yuanyuan Sun Yuanyuan Sun Hui Wang Hui Wang Zhengnong Chen Zhengnong Chen Yaqin Wu Yaqin Wu Haibo Shi Haibo Shi Yanmei Feng Yanmei Feng Shankai Yin Shankai Yin |
| author_sort | Zhong Zheng |
| collection | DOAJ |
| description | Objectives: As a common otology emergency, sudden sensorineural hearing loss (SSNHL) has a great impact on quality of life. The diagnosis and treatment of SSNHL remain challenging. This study aims to identify and investigate the association of liver functions with SSNHL.Methods: A total of 135 SSNHL patients and 135 sex- and age-matched controls were prospectively enrolled. The baseline and clinical characteristics, along with liver function levels of participators, were collected. Linear correlation, logistic regression, and receiving operator characteristic curve analysis tests were applied to examine the association between liver function levels and SSNHL.Results: There were no differences in baseline characteristics between SSNHL and control groups. The albumin (ALB) level of the SSNHL group was significantly lower than that in the control group (p < 0.001). The logistic regression showed that the low ALB level may be a predictive factor of SSNHL with an adjusted OR of 0.809 (95% CI, 0.742–0.882, p < 0.001). By comparing the indicators of different prognosis groups, we found that the effective group had a significantly lower hearing impair onset and higher ALB (p = 0.001) and AGR (p = 0.003) levels than the ineffective group. Logistic regression revealed that the hearing level onset (OR, 0.976; 95% CI, 0.956–0.997; p = 0.026) and ALB level (OR, 1.181; 95% CI, 1.071–1.301; p = 0.001) showed strong associations with treatment outcome.Conclusions: Lower ALB levels, within the normal ranges, were associated with the occurrence and unfavorable outcome of SSNHL. However, further research on the underlying mechanisms needs to be conducted. |
| first_indexed | 2024-12-16T08:43:32Z |
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| id | doaj.art-cf8191826b464e5eb4bfb05484e0e4ab |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-16T08:43:32Z |
| publishDate | 2021-10-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neurology |
| spelling | doaj.art-cf8191826b464e5eb4bfb05484e0e4ab2022-12-21T22:37:38ZengFrontiers Media S.A.Frontiers in Neurology1664-22952021-10-011210.3389/fneur.2021.747561747561Serum Albumin Levels as a Potential Marker for the Predictive and Prognostic Factor in Sudden Sensorineural Hearing Loss: A Prospective Cohort StudyZhong Zheng0Zhong Zheng1Chengqi Liu2Chengqi Liu3Ying Shen4Ying Shen5Liang Xia6Liang Xia7Lili Xiao8Lili Xiao9Yuanyuan Sun10Yuanyuan Sun11Hui Wang12Hui Wang13Zhengnong Chen14Zhengnong Chen15Yaqin Wu16Yaqin Wu17Haibo Shi18Haibo Shi19Yanmei Feng20Yanmei Feng21Shankai Yin22Shankai Yin23Department of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, ChinaShanghai Key Laboratory of Sleep Disordered Breathing, Shanghai, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, ChinaShanghai Key Laboratory of Sleep Disordered Breathing, Shanghai, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, ChinaShanghai Key Laboratory of Sleep Disordered Breathing, Shanghai, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, ChinaShanghai Key Laboratory of Sleep Disordered Breathing, Shanghai, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, ChinaShanghai Key Laboratory of Sleep Disordered Breathing, Shanghai, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, ChinaShanghai Key Laboratory of Sleep Disordered Breathing, Shanghai, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, ChinaShanghai Key Laboratory of Sleep Disordered Breathing, Shanghai, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, ChinaShanghai Key Laboratory of Sleep Disordered Breathing, Shanghai, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, ChinaShanghai Key Laboratory of Sleep Disordered Breathing, Shanghai, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, ChinaShanghai Key Laboratory of Sleep Disordered Breathing, Shanghai, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, ChinaShanghai Key Laboratory of Sleep Disordered Breathing, Shanghai, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, ChinaShanghai Key Laboratory of Sleep Disordered Breathing, Shanghai, ChinaObjectives: As a common otology emergency, sudden sensorineural hearing loss (SSNHL) has a great impact on quality of life. The diagnosis and treatment of SSNHL remain challenging. This study aims to identify and investigate the association of liver functions with SSNHL.Methods: A total of 135 SSNHL patients and 135 sex- and age-matched controls were prospectively enrolled. The baseline and clinical characteristics, along with liver function levels of participators, were collected. Linear correlation, logistic regression, and receiving operator characteristic curve analysis tests were applied to examine the association between liver function levels and SSNHL.Results: There were no differences in baseline characteristics between SSNHL and control groups. The albumin (ALB) level of the SSNHL group was significantly lower than that in the control group (p < 0.001). The logistic regression showed that the low ALB level may be a predictive factor of SSNHL with an adjusted OR of 0.809 (95% CI, 0.742–0.882, p < 0.001). By comparing the indicators of different prognosis groups, we found that the effective group had a significantly lower hearing impair onset and higher ALB (p = 0.001) and AGR (p = 0.003) levels than the ineffective group. Logistic regression revealed that the hearing level onset (OR, 0.976; 95% CI, 0.956–0.997; p = 0.026) and ALB level (OR, 1.181; 95% CI, 1.071–1.301; p = 0.001) showed strong associations with treatment outcome.Conclusions: Lower ALB levels, within the normal ranges, were associated with the occurrence and unfavorable outcome of SSNHL. However, further research on the underlying mechanisms needs to be conducted.https://www.frontiersin.org/articles/10.3389/fneur.2021.747561/fullsudden sensorineural hearing lossalbuminalbumin-to-globulin ratiopredictiveprognostic |
| spellingShingle | Zhong Zheng Zhong Zheng Chengqi Liu Chengqi Liu Ying Shen Ying Shen Liang Xia Liang Xia Lili Xiao Lili Xiao Yuanyuan Sun Yuanyuan Sun Hui Wang Hui Wang Zhengnong Chen Zhengnong Chen Yaqin Wu Yaqin Wu Haibo Shi Haibo Shi Yanmei Feng Yanmei Feng Shankai Yin Shankai Yin Serum Albumin Levels as a Potential Marker for the Predictive and Prognostic Factor in Sudden Sensorineural Hearing Loss: A Prospective Cohort Study Frontiers in Neurology sudden sensorineural hearing loss albumin albumin-to-globulin ratio predictive prognostic |
| title | Serum Albumin Levels as a Potential Marker for the Predictive and Prognostic Factor in Sudden Sensorineural Hearing Loss: A Prospective Cohort Study |
| title_full | Serum Albumin Levels as a Potential Marker for the Predictive and Prognostic Factor in Sudden Sensorineural Hearing Loss: A Prospective Cohort Study |
| title_fullStr | Serum Albumin Levels as a Potential Marker for the Predictive and Prognostic Factor in Sudden Sensorineural Hearing Loss: A Prospective Cohort Study |
| title_full_unstemmed | Serum Albumin Levels as a Potential Marker for the Predictive and Prognostic Factor in Sudden Sensorineural Hearing Loss: A Prospective Cohort Study |
| title_short | Serum Albumin Levels as a Potential Marker for the Predictive and Prognostic Factor in Sudden Sensorineural Hearing Loss: A Prospective Cohort Study |
| title_sort | serum albumin levels as a potential marker for the predictive and prognostic factor in sudden sensorineural hearing loss a prospective cohort study |
| topic | sudden sensorineural hearing loss albumin albumin-to-globulin ratio predictive prognostic |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2021.747561/full |
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