Resonant laser ionization and mass separation of 225Ac
Abstract $$^{225}$$ 225 Ac is a radio-isotope that can be linked to biological vector molecules to treat certain distributed cancers using targeted alpha therapy. However, developing $$^{225}$$ 225 Ac-labelled radiopharmaceuticals remains a challenge due to the supply shortage of pure $$^{225}$$ 225...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-28299-4 |
| _version_ | 1811175902663409664 |
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| author | Jake D. Johnson Michael Heines Frank Bruchertseifer Eric Chevallay Thomas E. Cocolios Kristof Dockx Charlotte Duchemin Stephan Heinitz Reinhard Heinke Sophie Hurier Laura Lambert Benji Leenders Hanna Skliarova Thierry Stora Wiktoria Wojtaczka |
| author_facet | Jake D. Johnson Michael Heines Frank Bruchertseifer Eric Chevallay Thomas E. Cocolios Kristof Dockx Charlotte Duchemin Stephan Heinitz Reinhard Heinke Sophie Hurier Laura Lambert Benji Leenders Hanna Skliarova Thierry Stora Wiktoria Wojtaczka |
| author_sort | Jake D. Johnson |
| collection | DOAJ |
| description | Abstract $$^{225}$$ 225 Ac is a radio-isotope that can be linked to biological vector molecules to treat certain distributed cancers using targeted alpha therapy. However, developing $$^{225}$$ 225 Ac-labelled radiopharmaceuticals remains a challenge due to the supply shortage of pure $$^{225}$$ 225 Ac itself. Several techniques to obtain pure $$^{225}$$ 225 Ac are being investigated, amongst which is the high-energy proton spallation of thorium or uranium combined with resonant laser ionization and mass separation. As a proof-of-principle, we perform off-line resonant ionization mass spectrometry on two samples of $$^{225}$$ 225 Ac, each with a known activity, in different chemical environments. We report overall operational collection efficiencies of 10.1(2)% and 9.9(8)% for the cases in which the $$^{225}$$ 225 Ac was deposited on a rhenium surface and a ThO $$_{2}$$ 2 mimic target matrix respectively. The bottleneck of the technique was the laser ionization efficiency, which was deduced to be 15.1(6)%. |
| first_indexed | 2024-04-10T19:44:37Z |
| format | Article |
| id | doaj.art-cf82a85391ca40a2992d3cfddaa18a36 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-10T19:44:37Z |
| publishDate | 2023-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-cf82a85391ca40a2992d3cfddaa18a362023-01-29T12:09:22ZengNature PortfolioScientific Reports2045-23222023-01-0113111110.1038/s41598-023-28299-4Resonant laser ionization and mass separation of 225AcJake D. Johnson0Michael Heines1Frank Bruchertseifer2Eric Chevallay3Thomas E. Cocolios4Kristof Dockx5Charlotte Duchemin6Stephan Heinitz7Reinhard Heinke8Sophie Hurier9Laura Lambert10Benji Leenders11Hanna Skliarova12Thierry Stora13Wiktoria Wojtaczka14KU Leuven, IKSKU Leuven, IKSJRCCERNKU Leuven, IKSKU Leuven, IKSKU Leuven, IKSBelgian Nuclear Research Centre SCK CENKU Leuven, IKSKU Leuven, IKSCERNBelgian Nuclear Research Centre SCK CENBelgian Nuclear Research Centre SCK CENCERNKU Leuven, IKSAbstract $$^{225}$$ 225 Ac is a radio-isotope that can be linked to biological vector molecules to treat certain distributed cancers using targeted alpha therapy. However, developing $$^{225}$$ 225 Ac-labelled radiopharmaceuticals remains a challenge due to the supply shortage of pure $$^{225}$$ 225 Ac itself. Several techniques to obtain pure $$^{225}$$ 225 Ac are being investigated, amongst which is the high-energy proton spallation of thorium or uranium combined with resonant laser ionization and mass separation. As a proof-of-principle, we perform off-line resonant ionization mass spectrometry on two samples of $$^{225}$$ 225 Ac, each with a known activity, in different chemical environments. We report overall operational collection efficiencies of 10.1(2)% and 9.9(8)% for the cases in which the $$^{225}$$ 225 Ac was deposited on a rhenium surface and a ThO $$_{2}$$ 2 mimic target matrix respectively. The bottleneck of the technique was the laser ionization efficiency, which was deduced to be 15.1(6)%.https://doi.org/10.1038/s41598-023-28299-4 |
| spellingShingle | Jake D. Johnson Michael Heines Frank Bruchertseifer Eric Chevallay Thomas E. Cocolios Kristof Dockx Charlotte Duchemin Stephan Heinitz Reinhard Heinke Sophie Hurier Laura Lambert Benji Leenders Hanna Skliarova Thierry Stora Wiktoria Wojtaczka Resonant laser ionization and mass separation of 225Ac Scientific Reports |
| title | Resonant laser ionization and mass separation of 225Ac |
| title_full | Resonant laser ionization and mass separation of 225Ac |
| title_fullStr | Resonant laser ionization and mass separation of 225Ac |
| title_full_unstemmed | Resonant laser ionization and mass separation of 225Ac |
| title_short | Resonant laser ionization and mass separation of 225Ac |
| title_sort | resonant laser ionization and mass separation of 225ac |
| url | https://doi.org/10.1038/s41598-023-28299-4 |
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