Occupational exposure to nanomaterials and biomarkers in exhaled air and urine: Insights from the NanoExplore international cohort
The current evidence on nanomaterial toxicity is mostly derived from experimental studies making it challenging to translate it into human health risks. We established an international cohort (N = 141 workers) within the EU-LIFE project “NanoExplore” to address possible health effects from occupatio...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Environment International |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412023004300 |
| _version_ | 1827816202972430336 |
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| author | Maud Hemmendinger Giulia Squillacioti Thomas Charreau Giacomo Garzaro Federica Ghelli Roberto Bono Jean-Jacques Sauvain Guillaume Suarez Nancy B. Hopf Pascal Wild Athena Progiou Carlos Fito Enrico Bergamaschi Irina Guseva Canu |
| author_facet | Maud Hemmendinger Giulia Squillacioti Thomas Charreau Giacomo Garzaro Federica Ghelli Roberto Bono Jean-Jacques Sauvain Guillaume Suarez Nancy B. Hopf Pascal Wild Athena Progiou Carlos Fito Enrico Bergamaschi Irina Guseva Canu |
| author_sort | Maud Hemmendinger |
| collection | DOAJ |
| description | The current evidence on nanomaterial toxicity is mostly derived from experimental studies making it challenging to translate it into human health risks. We established an international cohort (N = 141 workers) within the EU-LIFE project “NanoExplore” to address possible health effects from occupational exposures to nanomaterials. We used a handheld direct-reading optical particle counter to measure airborne nanoparticle number concentrations (PNC) and lung-deposited surface areas (LDSAs). Airborne particles were characterized by TEM and SEM-EDAX. We assessed oxidative/nitrosative stress with a panel of biomarkers in exhaled breath condensate (EBC) (8-isoprostane, malondialdehyde, nitrotyrosine), inflammation (high-sensitivity C reactive protein (hs-CRP), IL-1β, TNF-α, IL-10) and KL-6 (considered as biomarker of interstitial lung fibrosis) and urine (total antioxidant power (TAP), 8-isoprostane, and malondialdehyde). Exhaled breath sampled in gas-sampling bags were assessed for oxidative potential. These biomarkers were quantified pre-shift at the beginning of the workweek and post-shift the 4th day. Relationships between airborne nanoparticle concentration and biomarkers were assessed by multiple linear regression with log-transformed exposure and biomarker concentrations adjusted for potential confounders. We found a positive dose–response relationship for three inflammation biomarkers (IL-10, IL-1β and TNF-α) in EBC with both PNC and LDSA. A negative dose–response relationship was observed between PNC and TAP. This study suggests that occupational exposures to nanoparticles can affect the oxidative balance and the innate immunity in occupationally exposed workers. However, owing to the intrinsic variability of biomarkers, the observed changes along with their health significance should be assessed in a long-term perspective study. |
| first_indexed | 2024-03-12T00:11:30Z |
| format | Article |
| id | doaj.art-cf8589424c754d998ed173af80a6a2a4 |
| institution | Directory Open Access Journal |
| issn | 0160-4120 |
| language | English |
| last_indexed | 2024-03-12T00:11:30Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environment International |
| spelling | doaj.art-cf8589424c754d998ed173af80a6a2a42023-09-16T05:28:43ZengElsevierEnvironment International0160-41202023-09-01179108157Occupational exposure to nanomaterials and biomarkers in exhaled air and urine: Insights from the NanoExplore international cohortMaud Hemmendinger0Giulia Squillacioti1Thomas Charreau2Giacomo Garzaro3Federica Ghelli4Roberto Bono5Jean-Jacques Sauvain6Guillaume Suarez7Nancy B. Hopf8Pascal Wild9Athena Progiou10Carlos Fito11Enrico Bergamaschi12Irina Guseva Canu13Department of Occupational and Environmental Health, Center for Primary Care and Public Health (Unisanté), University of Lausanne, 1066 Epalinges, Lausanne, SwitzerlandDepartment of Public Health and Pediatrics, University of Turin - Via Santena 5 bis, 10126 Torino, ItalyDepartment of Occupational and Environmental Health, Center for Primary Care and Public Health (Unisanté), University of Lausanne, 1066 Epalinges, Lausanne, SwitzerlandDepartment of Public Health and Pediatrics, University of Turin, Via Zuretti 29, 10126 Torino, ItalyDepartment of Public Health and Pediatrics, University of Turin - Via Santena 5 bis, 10126 Torino, ItalyDepartment of Public Health and Pediatrics, University of Turin - Via Santena 5 bis, 10126 Torino, ItalyDepartment of Occupational and Environmental Health, Center for Primary Care and Public Health (Unisanté), University of Lausanne, 1066 Epalinges, Lausanne, SwitzerlandDepartment of Occupational and Environmental Health, Center for Primary Care and Public Health (Unisanté), University of Lausanne, 1066 Epalinges, Lausanne, SwitzerlandDepartment of Occupational and Environmental Health, Center for Primary Care and Public Health (Unisanté), University of Lausanne, 1066 Epalinges, Lausanne, SwitzerlandDepartment of Occupational and Environmental Health, Center for Primary Care and Public Health (Unisanté), University of Lausanne, 1066 Epalinges, Lausanne, SwitzerlandALCON Consultant Engineers Ltd., 18Τroias street, 11257 Athens, GreeceInstituto tecnológico del embalaje, transporte y logística (ITENE), C/Albert Einstein 1, 46980 Paterna, Valencia, SpainDepartment of Public Health and Pediatrics, University of Turin, Via Zuretti 29, 10126 Torino, ItalyDepartment of Occupational and Environmental Health, Center for Primary Care and Public Health (Unisanté), University of Lausanne, 1066 Epalinges, Lausanne, Switzerland; Corresponding author at: Route de la Corniche, 2, 1066 Epalinges-Lausanne, Switzerland.The current evidence on nanomaterial toxicity is mostly derived from experimental studies making it challenging to translate it into human health risks. We established an international cohort (N = 141 workers) within the EU-LIFE project “NanoExplore” to address possible health effects from occupational exposures to nanomaterials. We used a handheld direct-reading optical particle counter to measure airborne nanoparticle number concentrations (PNC) and lung-deposited surface areas (LDSAs). Airborne particles were characterized by TEM and SEM-EDAX. We assessed oxidative/nitrosative stress with a panel of biomarkers in exhaled breath condensate (EBC) (8-isoprostane, malondialdehyde, nitrotyrosine), inflammation (high-sensitivity C reactive protein (hs-CRP), IL-1β, TNF-α, IL-10) and KL-6 (considered as biomarker of interstitial lung fibrosis) and urine (total antioxidant power (TAP), 8-isoprostane, and malondialdehyde). Exhaled breath sampled in gas-sampling bags were assessed for oxidative potential. These biomarkers were quantified pre-shift at the beginning of the workweek and post-shift the 4th day. Relationships between airborne nanoparticle concentration and biomarkers were assessed by multiple linear regression with log-transformed exposure and biomarker concentrations adjusted for potential confounders. We found a positive dose–response relationship for three inflammation biomarkers (IL-10, IL-1β and TNF-α) in EBC with both PNC and LDSA. A negative dose–response relationship was observed between PNC and TAP. This study suggests that occupational exposures to nanoparticles can affect the oxidative balance and the innate immunity in occupationally exposed workers. However, owing to the intrinsic variability of biomarkers, the observed changes along with their health significance should be assessed in a long-term perspective study.http://www.sciencedirect.com/science/article/pii/S0160412023004300NanoparticlesOccupational exposureExhaled breath condensateUrineEpidemiological study |
| spellingShingle | Maud Hemmendinger Giulia Squillacioti Thomas Charreau Giacomo Garzaro Federica Ghelli Roberto Bono Jean-Jacques Sauvain Guillaume Suarez Nancy B. Hopf Pascal Wild Athena Progiou Carlos Fito Enrico Bergamaschi Irina Guseva Canu Occupational exposure to nanomaterials and biomarkers in exhaled air and urine: Insights from the NanoExplore international cohort Environment International Nanoparticles Occupational exposure Exhaled breath condensate Urine Epidemiological study |
| title | Occupational exposure to nanomaterials and biomarkers in exhaled air and urine: Insights from the NanoExplore international cohort |
| title_full | Occupational exposure to nanomaterials and biomarkers in exhaled air and urine: Insights from the NanoExplore international cohort |
| title_fullStr | Occupational exposure to nanomaterials and biomarkers in exhaled air and urine: Insights from the NanoExplore international cohort |
| title_full_unstemmed | Occupational exposure to nanomaterials and biomarkers in exhaled air and urine: Insights from the NanoExplore international cohort |
| title_short | Occupational exposure to nanomaterials and biomarkers in exhaled air and urine: Insights from the NanoExplore international cohort |
| title_sort | occupational exposure to nanomaterials and biomarkers in exhaled air and urine insights from the nanoexplore international cohort |
| topic | Nanoparticles Occupational exposure Exhaled breath condensate Urine Epidemiological study |
| url | http://www.sciencedirect.com/science/article/pii/S0160412023004300 |
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