TRIB3 silencing promotes the downregulation of Akt pathway and PAX3-FOXO1 in high-risk rhabdomyosarcoma

TRIB3 silencing promotes the downregulation of Akt pathway and PAX3-FOXO1 in high-risk rhabdomyosarcoma

Abstract Rhabdomyosarcoma (RMS), such as other childhood tumors, has witnessed treatment advancements in recent years. However, high-risk patients continue to face poor survival rates, often attributed to the presence of the PAX3/7-FOXO1 fusion proteins, which has been associated with metastasis and...

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Bibliographic Details
Main Authors: Gabriel Gallo-Oller, Guillem Pons, Júlia Sansa-Girona, Natalia Navarro, Patricia Zarzosa, Lia García-Gilabert, Paula Cabré-Fernandez, Gabriela Guillén Burrieza, Lorena Valero-Arrese, Miguel F. Segura, José M. Lizcano, José Sánchez de Toledo, Lucas Moreno, Soledad Gallego, Josep Roma
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Experimental Hematology & Oncology
Subjects:
TRIB3
Fusion protein
PAX3-FOXO1
Akt
Rhabdomyosarcoma
Online Access:https://doi.org/10.1186/s40164-024-00503-9

Internet

https://doi.org/10.1186/s40164-024-00503-9

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