Time Series Analysis of Fed-batch Fermentation Process for L-valine Production

Fed-batch fermentation processes are some of the most efficient and wildly applied types of cultivation for industrial production of most amino acids including L-valine. Time series analysis is an important tool for description of the experimental data. This article deals with statistical inference...

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Bibliographic Details
Main Authors: Tzanko Georgiev, Velitchka Ivanova, KalinTodorov, Julia Kristeva, Ignat Dimov, Alexander Ratkov
Format: Article
Language:English
Published: Academic Publishing House 2006-04-01
Series:Bioautomation
Subjects:
Online Access:http://www.clbme.bas.bg/bioautomation/2006/vol_4.1/files/4_1.3.pdf
Description
Summary:Fed-batch fermentation processes are some of the most efficient and wildly applied types of cultivation for industrial production of most amino acids including L-valine. Time series analysis is an important tool for description of the experimental data. This article deals with statistical inference from the time series analysis of generalised stoichiometric equations as a hypothesis for modelling and optimisation. The aim of the article is to develop some time series models of generalized stoichiometric equations. The identification procedure includes the following steps: description of the process by generalized stoichiometric equations; preliminary data processing; model structure selection for each stoichiometric equation; estimation of the model's parameters; verification of the derived models.
ISSN:1313-261X
1312-451X