Risk of overhydration and low lean tissue index as measured using a body composition monitor in patients on hemodialysis: a systemic review and meta-analysis
Overhydration and sarcopenia, related to an individual’s nutritional status, have been associated with increased cardiovascular mortality and poor prognosis in patients on hemodialysis. The purpose of this study was to investigate the prediction of overhydration and sarcopenia on mortality in patien...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-10-01
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| Series: | Renal Failure |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/0886022X.2017.1419963 |
| _version_ | 1818893639267385344 |
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| author | Seun Deuk Hwang Jin Ho Lee Seoung Woo Lee Joong Kyung Kim Moon-Jae Kim Joon Ho Song |
| author_facet | Seun Deuk Hwang Jin Ho Lee Seoung Woo Lee Joong Kyung Kim Moon-Jae Kim Joon Ho Song |
| author_sort | Seun Deuk Hwang |
| collection | DOAJ |
| description | Overhydration and sarcopenia, related to an individual’s nutritional status, have been associated with increased cardiovascular mortality and poor prognosis in patients on hemodialysis. The purpose of this study was to investigate the prediction of overhydration and sarcopenia on mortality in patients on hemodialysis using a body composition monitor. We conducted a systematic review and meta-analysis using a random-effects model. We searched the Cochrane Central Register, OVID MEDLINE, EMBASE and PubMed databases for all studies published prior to December 9, 2016 and reviewed the reference lists of relevant reviews, registered trials and relevant conference proceedings. The overhydration group (fluid excess, >15% vs. the normohydration group) and the low lean tissue index group ( <10%) were compared with a reference group. Six trials, consisting of 29,469 patients, were included in the pooled analysis. The pooled hazard ratio for overall survival of the overhydration group, compared with the reference normohydration group was 1.798 (95% confidence interval [CI]: 1.53–2.804, p = .001). The hazard ratio for mortality in the low lean tissue index group was 1.533 (95% CI, 1.411–1.644; p = .001) in the random-effects model. The results from the most recent study showed the greatest heterogeneity in the sensitivity analysis. Low lean tissue index and overhydration, measured using a body composition monitor, were associated with a high mortality rate in patients on hemodialysis. |
| first_indexed | 2024-12-19T18:15:48Z |
| format | Article |
| id | doaj.art-cf8898b9df804c8591433e4625349fb2 |
| institution | Directory Open Access Journal |
| issn | 0886-022X 1525-6049 |
| language | English |
| last_indexed | 2024-12-19T18:15:48Z |
| publishDate | 2018-10-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj.art-cf8898b9df804c8591433e4625349fb22022-12-21T20:11:07ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492018-10-01401515910.1080/0886022X.2017.14199631419963Risk of overhydration and low lean tissue index as measured using a body composition monitor in patients on hemodialysis: a systemic review and meta-analysisSeun Deuk Hwang0Jin Ho Lee1Seoung Woo Lee2Joong Kyung Kim3Moon-Jae Kim4Joon Ho Song5Inha University College of MedicineBong Seng Memorial HospitalInha University College of MedicineBong Seng Memorial HospitalInha University College of MedicineInha University College of MedicineOverhydration and sarcopenia, related to an individual’s nutritional status, have been associated with increased cardiovascular mortality and poor prognosis in patients on hemodialysis. The purpose of this study was to investigate the prediction of overhydration and sarcopenia on mortality in patients on hemodialysis using a body composition monitor. We conducted a systematic review and meta-analysis using a random-effects model. We searched the Cochrane Central Register, OVID MEDLINE, EMBASE and PubMed databases for all studies published prior to December 9, 2016 and reviewed the reference lists of relevant reviews, registered trials and relevant conference proceedings. The overhydration group (fluid excess, >15% vs. the normohydration group) and the low lean tissue index group ( <10%) were compared with a reference group. Six trials, consisting of 29,469 patients, were included in the pooled analysis. The pooled hazard ratio for overall survival of the overhydration group, compared with the reference normohydration group was 1.798 (95% confidence interval [CI]: 1.53–2.804, p = .001). The hazard ratio for mortality in the low lean tissue index group was 1.533 (95% CI, 1.411–1.644; p = .001) in the random-effects model. The results from the most recent study showed the greatest heterogeneity in the sensitivity analysis. Low lean tissue index and overhydration, measured using a body composition monitor, were associated with a high mortality rate in patients on hemodialysis.http://dx.doi.org/10.1080/0886022X.2017.1419963Overhydrationlean tissue indexbody composition monitorhemodialysisend stage renal disease |
| spellingShingle | Seun Deuk Hwang Jin Ho Lee Seoung Woo Lee Joong Kyung Kim Moon-Jae Kim Joon Ho Song Risk of overhydration and low lean tissue index as measured using a body composition monitor in patients on hemodialysis: a systemic review and meta-analysis Renal Failure Overhydration lean tissue index body composition monitor hemodialysis end stage renal disease |
| title | Risk of overhydration and low lean tissue index as measured using a body composition monitor in patients on hemodialysis: a systemic review and meta-analysis |
| title_full | Risk of overhydration and low lean tissue index as measured using a body composition monitor in patients on hemodialysis: a systemic review and meta-analysis |
| title_fullStr | Risk of overhydration and low lean tissue index as measured using a body composition monitor in patients on hemodialysis: a systemic review and meta-analysis |
| title_full_unstemmed | Risk of overhydration and low lean tissue index as measured using a body composition monitor in patients on hemodialysis: a systemic review and meta-analysis |
| title_short | Risk of overhydration and low lean tissue index as measured using a body composition monitor in patients on hemodialysis: a systemic review and meta-analysis |
| title_sort | risk of overhydration and low lean tissue index as measured using a body composition monitor in patients on hemodialysis a systemic review and meta analysis |
| topic | Overhydration lean tissue index body composition monitor hemodialysis end stage renal disease |
| url | http://dx.doi.org/10.1080/0886022X.2017.1419963 |
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