Roles of intercellular cell adhesion molecule-1 (ICAM-1) in colorectal cancer: expression, functions, prognosis, tumorigenesis, polymorphisms and therapeutic implications
Colorectal cancer (CRC) is a major global health problem and one of the major causes of cancer-related death worldwide. It is very important to understand the pathogenesis of CRC for early diagnosis, prevention strategies and identification of new therapeutic targets. Intercellular adhesion molecule...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.1052672/full |
| _version_ | 1811179804385345536 |
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| author | Zhiyuan Qiu Yan Wang Zhao Zhang Rong Qin Yong Peng Weifeng Tang Yan Xi Guangyu Tian Yeqing Zhang |
| author_facet | Zhiyuan Qiu Yan Wang Zhao Zhang Rong Qin Yong Peng Weifeng Tang Yan Xi Guangyu Tian Yeqing Zhang |
| author_sort | Zhiyuan Qiu |
| collection | DOAJ |
| description | Colorectal cancer (CRC) is a major global health problem and one of the major causes of cancer-related death worldwide. It is very important to understand the pathogenesis of CRC for early diagnosis, prevention strategies and identification of new therapeutic targets. Intercellular adhesion molecule-1 (ICAM-1, CD54) displays an important role in the the pathogenesis of CRC. It is a cell surface glycoprotein of the immunoglobulin (Ig) superfamily and plays an essential role in cell-cell, cell-extracellular matrix interaction, cell signaling and immune process. It is also expressed by tumor cells and modulates their functions, including apoptosis, cell motility, invasion and angiogenesis. The interaction between ICAM-1 and its ligand may facilitate adhesion of tumor cells to the vascular endothelium and subsequently in the promotion of metastasis. ICAM-1 expression determines malignant potential of cancer. In this review, we will discuss the expression, function, prognosis, tumorigenesis, polymorphisms and therapeutic implications of ICAM-1 in CRC. |
| first_indexed | 2024-04-11T06:40:49Z |
| format | Article |
| id | doaj.art-cf88cf06c27348728d7e5cc9f04f7d0a |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-11T06:40:49Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-cf88cf06c27348728d7e5cc9f04f7d0a2022-12-22T04:39:33ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-11-011210.3389/fonc.2022.10526721052672Roles of intercellular cell adhesion molecule-1 (ICAM-1) in colorectal cancer: expression, functions, prognosis, tumorigenesis, polymorphisms and therapeutic implicationsZhiyuan Qiu0Yan Wang1Zhao Zhang2Rong Qin3Yong Peng4Weifeng Tang5Yan Xi6Guangyu Tian7Yeqing Zhang8Department of Oncology, the Affiliated People’s Hospital of Jiangsu University, Zhenjiang, Jiangsu, ChinaDepartment of Oncology, the Affiliated People’s Hospital of Jiangsu University, Zhenjiang, Jiangsu, ChinaDepartment of Oncology, the Affiliated People’s Hospital of Jiangsu University, Zhenjiang, Jiangsu, ChinaDepartment of Oncology, the Affiliated People’s Hospital of Jiangsu University, Zhenjiang, Jiangsu, ChinaDepartment of Oncology, the Affiliated People’s Hospital of Jiangsu University, Zhenjiang, Jiangsu, ChinaDepartment of Cardiothoracic Surgery, Nanjing Drum Tower Hospital, Nanjing, Jiangsu, ChinaDepartment of Geriatrics, the Affiliated People’s Hospital of Jiangsu University, Zhenjiang, Jiangsu, ChinaDepartment of Oncology, Jiangdu People’s Hospital Affiliated to Medical College of Yangzhou University, Yangzhou, Jiangsu, ChinaDepartment of Vascular Surgery, the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, ChinaColorectal cancer (CRC) is a major global health problem and one of the major causes of cancer-related death worldwide. It is very important to understand the pathogenesis of CRC for early diagnosis, prevention strategies and identification of new therapeutic targets. Intercellular adhesion molecule-1 (ICAM-1, CD54) displays an important role in the the pathogenesis of CRC. It is a cell surface glycoprotein of the immunoglobulin (Ig) superfamily and plays an essential role in cell-cell, cell-extracellular matrix interaction, cell signaling and immune process. It is also expressed by tumor cells and modulates their functions, including apoptosis, cell motility, invasion and angiogenesis. The interaction between ICAM-1 and its ligand may facilitate adhesion of tumor cells to the vascular endothelium and subsequently in the promotion of metastasis. ICAM-1 expression determines malignant potential of cancer. In this review, we will discuss the expression, function, prognosis, tumorigenesis, polymorphisms and therapeutic implications of ICAM-1 in CRC.https://www.frontiersin.org/articles/10.3389/fonc.2022.1052672/fullICAM-1colorectal cancerpolymorphismsprognosistumorigenesis |
| spellingShingle | Zhiyuan Qiu Yan Wang Zhao Zhang Rong Qin Yong Peng Weifeng Tang Yan Xi Guangyu Tian Yeqing Zhang Roles of intercellular cell adhesion molecule-1 (ICAM-1) in colorectal cancer: expression, functions, prognosis, tumorigenesis, polymorphisms and therapeutic implications Frontiers in Oncology ICAM-1 colorectal cancer polymorphisms prognosis tumorigenesis |
| title | Roles of intercellular cell adhesion molecule-1 (ICAM-1) in colorectal cancer: expression, functions, prognosis, tumorigenesis, polymorphisms and therapeutic implications |
| title_full | Roles of intercellular cell adhesion molecule-1 (ICAM-1) in colorectal cancer: expression, functions, prognosis, tumorigenesis, polymorphisms and therapeutic implications |
| title_fullStr | Roles of intercellular cell adhesion molecule-1 (ICAM-1) in colorectal cancer: expression, functions, prognosis, tumorigenesis, polymorphisms and therapeutic implications |
| title_full_unstemmed | Roles of intercellular cell adhesion molecule-1 (ICAM-1) in colorectal cancer: expression, functions, prognosis, tumorigenesis, polymorphisms and therapeutic implications |
| title_short | Roles of intercellular cell adhesion molecule-1 (ICAM-1) in colorectal cancer: expression, functions, prognosis, tumorigenesis, polymorphisms and therapeutic implications |
| title_sort | roles of intercellular cell adhesion molecule 1 icam 1 in colorectal cancer expression functions prognosis tumorigenesis polymorphisms and therapeutic implications |
| topic | ICAM-1 colorectal cancer polymorphisms prognosis tumorigenesis |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.1052672/full |
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