Extent of myosin penetration within the actin cortex regulates cell surface mechanics
Cellular deformations are largely driven by contractile forces generated by myosin motors in the submembraneous actin cortex. Here we show that these forces are controlled not simply by cortical myosin levels, but rather by myosins spatial arrangement, specifically the extent of their overlap with c...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-26611-2 |
| _version_ | 1818927266353119232 |
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| author | Binh An Truong Quang Ruby Peters Davide A. D. Cassani Priyamvada Chugh Andrew G. Clark Meghan Agnew Guillaume Charras Ewa K. Paluch |
| author_facet | Binh An Truong Quang Ruby Peters Davide A. D. Cassani Priyamvada Chugh Andrew G. Clark Meghan Agnew Guillaume Charras Ewa K. Paluch |
| author_sort | Binh An Truong Quang |
| collection | DOAJ |
| description | Cellular deformations are largely driven by contractile forces generated by myosin motors in the submembraneous actin cortex. Here we show that these forces are controlled not simply by cortical myosin levels, but rather by myosins spatial arrangement, specifically the extent of their overlap with cortical actin. |
| first_indexed | 2024-12-20T03:10:17Z |
| format | Article |
| id | doaj.art-cf89e257b5b749cea33f19cc411e938e |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T03:10:17Z |
| publishDate | 2021-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-cf89e257b5b749cea33f19cc411e938e2022-12-21T19:55:30ZengNature PortfolioNature Communications2041-17232021-11-0112111210.1038/s41467-021-26611-2Extent of myosin penetration within the actin cortex regulates cell surface mechanicsBinh An Truong Quang0Ruby Peters1Davide A. D. Cassani2Priyamvada Chugh3Andrew G. Clark4Meghan Agnew5Guillaume Charras6Ewa K. Paluch7MRC Laboratory for Molecular Cell Biology, University College LondonDepartment of Physiology, Development and Neuroscience, University of CambridgeMRC Laboratory for Molecular Cell Biology, University College LondonMRC Laboratory for Molecular Cell Biology, University College LondonMRC Laboratory for Molecular Cell Biology, University College LondonMRC Laboratory for Molecular Cell Biology, University College LondonLondon Centre for Nanotechnology, University College LondonMRC Laboratory for Molecular Cell Biology, University College LondonCellular deformations are largely driven by contractile forces generated by myosin motors in the submembraneous actin cortex. Here we show that these forces are controlled not simply by cortical myosin levels, but rather by myosins spatial arrangement, specifically the extent of their overlap with cortical actin.https://doi.org/10.1038/s41467-021-26611-2 |
| spellingShingle | Binh An Truong Quang Ruby Peters Davide A. D. Cassani Priyamvada Chugh Andrew G. Clark Meghan Agnew Guillaume Charras Ewa K. Paluch Extent of myosin penetration within the actin cortex regulates cell surface mechanics Nature Communications |
| title | Extent of myosin penetration within the actin cortex regulates cell surface mechanics |
| title_full | Extent of myosin penetration within the actin cortex regulates cell surface mechanics |
| title_fullStr | Extent of myosin penetration within the actin cortex regulates cell surface mechanics |
| title_full_unstemmed | Extent of myosin penetration within the actin cortex regulates cell surface mechanics |
| title_short | Extent of myosin penetration within the actin cortex regulates cell surface mechanics |
| title_sort | extent of myosin penetration within the actin cortex regulates cell surface mechanics |
| url | https://doi.org/10.1038/s41467-021-26611-2 |
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