Differential Associations Between Distinct Components of Cognitive Function and Mobility: Implications for Understanding Aging, Turning and Dual-Task Walking
ObjectiveCognition and mobility are interrelated. However, this association can be impacted by the specific facets of cognition and mobility that are measured, and further by the different task conditions, e.g., single- versus dual-task walking, under which these associations are evaluated. Systemat...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-07-01
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| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fnagi.2019.00166/full |
| _version_ | 1819231680100040704 |
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| author | Preeti Sunderaraman Inbal Maidan Inbal Maidan Tal Kozlovski Zoltan Apa Anat Mirelman Anat Mirelman Jeffrey M. Hausdorff Jeffrey M. Hausdorff Jeffrey M. Hausdorff Yaakov Stern Yaakov Stern |
| author_facet | Preeti Sunderaraman Inbal Maidan Inbal Maidan Tal Kozlovski Zoltan Apa Anat Mirelman Anat Mirelman Jeffrey M. Hausdorff Jeffrey M. Hausdorff Jeffrey M. Hausdorff Yaakov Stern Yaakov Stern |
| author_sort | Preeti Sunderaraman |
| collection | DOAJ |
| description | ObjectiveCognition and mobility are interrelated. However, this association can be impacted by the specific facets of cognition and mobility that are measured, and further by the different task conditions, e.g., single- versus dual-task walking, under which these associations are evaluated. Systematically studying the multiple facets of cognitive-mobility associations under both the task conditions is critical because both cognition and mobility change with age and pose significant risks associated with falls, morbidity, and disability.MethodsUsing a cross-sectional, prospective study design, data from 124 healthy adults [mean age (SD) = 61.51 (11.90); mean education (SD) = 15.94 (2.18)] were collected. A comprehensive battery of cognitive tests was administered, and gait was assessed using a small, lightweight, three-axis accelerometer with a gyroscope.Analytical PlanData were transformed, and only relatively strong relationships survived after strict statistical criteria adjusting for multiple comparisons were applied. Spearman rho correlation coefficients were used to examine the matrix of correlations between the cognitive-motor variables while adjusting for age and gender.ResultsExecutive functions, processing speed, and language were associated with distinct facets of variability, pace, and asymmetry, especially under the dual-task walking condition. Both turns and transitions were also associated with cognition during the Timed Up and Go Task.ConclusionOur results extend converging evidence of the involvement of executive functions and processing speed in specific aspects of mobility, along with the role of language. The study has important implications for aging in terms of both assessment and rehabilitation of cognition and gait as well as for the emerging dual-tasking theories and the role of the neural pathways involved in mobility. |
| first_indexed | 2024-12-23T11:48:48Z |
| format | Article |
| id | doaj.art-cf8c653c87fd48b7b65487f38fa59ef1 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-23T11:48:48Z |
| publishDate | 2019-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-cf8c653c87fd48b7b65487f38fa59ef12022-12-21T17:48:17ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652019-07-011110.3389/fnagi.2019.00166455092Differential Associations Between Distinct Components of Cognitive Function and Mobility: Implications for Understanding Aging, Turning and Dual-Task WalkingPreeti Sunderaraman0Inbal Maidan1Inbal Maidan2Tal Kozlovski3Zoltan Apa4Anat Mirelman5Anat Mirelman6Jeffrey M. Hausdorff7Jeffrey M. Hausdorff8Jeffrey M. Hausdorff9Yaakov Stern10Yaakov Stern11Cognitive Neuroscience Division, Gertrude H. Sergievsky Center, Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, United StatesCenter for the Study of Movement Cognition and Mobility, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, IsraelDepartment of Neurology and Neurosurgery, Sackler Faculty of Medicine, and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, IsraelCenter for the Study of Movement Cognition and Mobility, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, IsraelCognitive Neuroscience Division, Gertrude H. Sergievsky Center, Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, United StatesCenter for the Study of Movement Cognition and Mobility, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, IsraelDepartment of Neurology and Neurosurgery, Sackler Faculty of Medicine, and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, IsraelCenter for the Study of Movement Cognition and Mobility, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, IsraelDepartment of Physical Therapy, Sackler Faculty of Medicine, and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, IsraelRush Alzheimer’s Disease Center and Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL, United StatesCognitive Neuroscience Division, Gertrude H. Sergievsky Center, Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, United StatesDepartment of Neurology, Columbia University Irving Medical Center, New York, NY, United StatesObjectiveCognition and mobility are interrelated. However, this association can be impacted by the specific facets of cognition and mobility that are measured, and further by the different task conditions, e.g., single- versus dual-task walking, under which these associations are evaluated. Systematically studying the multiple facets of cognitive-mobility associations under both the task conditions is critical because both cognition and mobility change with age and pose significant risks associated with falls, morbidity, and disability.MethodsUsing a cross-sectional, prospective study design, data from 124 healthy adults [mean age (SD) = 61.51 (11.90); mean education (SD) = 15.94 (2.18)] were collected. A comprehensive battery of cognitive tests was administered, and gait was assessed using a small, lightweight, three-axis accelerometer with a gyroscope.Analytical PlanData were transformed, and only relatively strong relationships survived after strict statistical criteria adjusting for multiple comparisons were applied. Spearman rho correlation coefficients were used to examine the matrix of correlations between the cognitive-motor variables while adjusting for age and gender.ResultsExecutive functions, processing speed, and language were associated with distinct facets of variability, pace, and asymmetry, especially under the dual-task walking condition. Both turns and transitions were also associated with cognition during the Timed Up and Go Task.ConclusionOur results extend converging evidence of the involvement of executive functions and processing speed in specific aspects of mobility, along with the role of language. The study has important implications for aging in terms of both assessment and rehabilitation of cognition and gait as well as for the emerging dual-tasking theories and the role of the neural pathways involved in mobility.https://www.frontiersin.org/article/10.3389/fnagi.2019.00166/fullmobilitygaitcognitionagingelderlyexecutive function |
| spellingShingle | Preeti Sunderaraman Inbal Maidan Inbal Maidan Tal Kozlovski Zoltan Apa Anat Mirelman Anat Mirelman Jeffrey M. Hausdorff Jeffrey M. Hausdorff Jeffrey M. Hausdorff Yaakov Stern Yaakov Stern Differential Associations Between Distinct Components of Cognitive Function and Mobility: Implications for Understanding Aging, Turning and Dual-Task Walking Frontiers in Aging Neuroscience mobility gait cognition aging elderly executive function |
| title | Differential Associations Between Distinct Components of Cognitive Function and Mobility: Implications for Understanding Aging, Turning and Dual-Task Walking |
| title_full | Differential Associations Between Distinct Components of Cognitive Function and Mobility: Implications for Understanding Aging, Turning and Dual-Task Walking |
| title_fullStr | Differential Associations Between Distinct Components of Cognitive Function and Mobility: Implications for Understanding Aging, Turning and Dual-Task Walking |
| title_full_unstemmed | Differential Associations Between Distinct Components of Cognitive Function and Mobility: Implications for Understanding Aging, Turning and Dual-Task Walking |
| title_short | Differential Associations Between Distinct Components of Cognitive Function and Mobility: Implications for Understanding Aging, Turning and Dual-Task Walking |
| title_sort | differential associations between distinct components of cognitive function and mobility implications for understanding aging turning and dual task walking |
| topic | mobility gait cognition aging elderly executive function |
| url | https://www.frontiersin.org/article/10.3389/fnagi.2019.00166/full |
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