Skeletal muscle tissue engineering: strategies for volumetric constructs
Skeletal muscle tissue is characterized by high metabolic requirements, defined structure and high regenerative potential. As such, it constitutes an appealing platform for tissue engineering to address volumetric defects, as proven by recent works in this field.Several issues common to all engineer...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2014-09-01
|
| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00362/full |
| _version_ | 1828157908706131968 |
|---|---|
| author | Giorgio eCittadella Vigodarzere Sara eMantero |
| author_facet | Giorgio eCittadella Vigodarzere Sara eMantero |
| author_sort | Giorgio eCittadella Vigodarzere |
| collection | DOAJ |
| description | Skeletal muscle tissue is characterized by high metabolic requirements, defined structure and high regenerative potential. As such, it constitutes an appealing platform for tissue engineering to address volumetric defects, as proven by recent works in this field.Several issues common to all engineered constructs constrain the variety of tissues that can be realized in vitro, principal among them the lack of a vascular system and the absence of reliable cell sources; as it is, the only successful tissue engineering constructs are not characterized by active function, present limited cellular survival at implantation and possess low metabolic requirements.Recently, functionally competent constructs have been engineered, with vascular structures supporting their metabolic requirements. In addition to the use of biochemical cues, physical means, mechanical stimulation and the application of electric tension have proven effective in stimulating the differentiation of cells and the maturation of the constructs; while the use of co-cultures provided fine control of cellular developments through paracrine activity. This review will provide a brief analysis of some of the most promising improvements in the field, with particular attention to the techniques that could prove easily transferable to other branches of tissue engineering. |
| first_indexed | 2024-04-11T23:37:08Z |
| format | Article |
| id | doaj.art-cf8ea2a73bc844b1bfb6d19ee24bb0b7 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-11T23:37:08Z |
| publishDate | 2014-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-cf8ea2a73bc844b1bfb6d19ee24bb0b72022-12-22T03:56:55ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2014-09-01510.3389/fphys.2014.00362110643Skeletal muscle tissue engineering: strategies for volumetric constructsGiorgio eCittadella Vigodarzere0Sara eMantero1Politecnico di MilanoPolitecnico di MilanoSkeletal muscle tissue is characterized by high metabolic requirements, defined structure and high regenerative potential. As such, it constitutes an appealing platform for tissue engineering to address volumetric defects, as proven by recent works in this field.Several issues common to all engineered constructs constrain the variety of tissues that can be realized in vitro, principal among them the lack of a vascular system and the absence of reliable cell sources; as it is, the only successful tissue engineering constructs are not characterized by active function, present limited cellular survival at implantation and possess low metabolic requirements.Recently, functionally competent constructs have been engineered, with vascular structures supporting their metabolic requirements. In addition to the use of biochemical cues, physical means, mechanical stimulation and the application of electric tension have proven effective in stimulating the differentiation of cells and the maturation of the constructs; while the use of co-cultures provided fine control of cellular developments through paracrine activity. This review will provide a brief analysis of some of the most promising improvements in the field, with particular attention to the techniques that could prove easily transferable to other branches of tissue engineering.http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00362/fullPhysical StimulationTissue Engineeringskeletal musclemechanobiologyvascularization. |
| spellingShingle | Giorgio eCittadella Vigodarzere Sara eMantero Skeletal muscle tissue engineering: strategies for volumetric constructs Frontiers in Physiology Physical Stimulation Tissue Engineering skeletal muscle mechanobiology vascularization. |
| title | Skeletal muscle tissue engineering: strategies for volumetric constructs |
| title_full | Skeletal muscle tissue engineering: strategies for volumetric constructs |
| title_fullStr | Skeletal muscle tissue engineering: strategies for volumetric constructs |
| title_full_unstemmed | Skeletal muscle tissue engineering: strategies for volumetric constructs |
| title_short | Skeletal muscle tissue engineering: strategies for volumetric constructs |
| title_sort | skeletal muscle tissue engineering strategies for volumetric constructs |
| topic | Physical Stimulation Tissue Engineering skeletal muscle mechanobiology vascularization. |
| url | http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00362/full |
| work_keys_str_mv | AT giorgioecittadellavigodarzere skeletalmuscletissueengineeringstrategiesforvolumetricconstructs AT saraemantero skeletalmuscletissueengineeringstrategiesforvolumetricconstructs |