Synthesis, Structure and Antileishmanial Evaluation of Endoperoxide–Pyrazole Hybrids

Synthesis, Structure and Antileishmanial Evaluation of Endoperoxide–Pyrazole Hybrids

Leishmaniases are among the most impacting neglected tropical diseases. In attempts to repurpose antimalarial drugs or candidates, it was found that selected 1,2,4-trioxanes, 1,2,4,5-tetraoxanes, and pyrazole-containing chemotypes demonstrated activity against <i>Leishmania</i> parasites...

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Bibliographic Details
Main Authors:	Patrícia S. M. Amado, Inês C. C. Costa, José A. Paixão, Ricardo F. Mendes, Sofia Cortes, Maria L. S. Cristiano
Format:	Article
Language:	English
Published:	MDPI AG 2022-08-01
Series:	Molecules
Subjects:	antileishmanial chemotherapy 1,2,4-trioxanes 1,2,4,5-tetraoxanes pyrazoles endoperoxide–pyrazole hybrids prototropic tautomerism
Online Access:	https://www.mdpi.com/1420-3049/27/17/5401

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