Visual analysis of high density EEG: As good as electrical source imaging?
Objective: In this study, we sought to determine whether visual analysis of high density EEG (HD-EEG) would provide similar localizing information comparable to electrical source imaging (ESI). Methods: HD-EEG (256 electrodes) recordings from 20 patients suffering from unifocal, drug-resistant epile...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-01-01
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| Series: | Clinical Neurophysiology Practice |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2467981X1930040X |
| _version_ | 1818838947535519744 |
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| author | Gianpaolo Toscano Margherita Carboni Maria Rubega Laurent Spinelli Francesca Pittau Andrea Bartoli Shahan Momjian Raffaele Manni Michele Terzaghi Serge Vulliemoz Margitta Seeck |
| author_facet | Gianpaolo Toscano Margherita Carboni Maria Rubega Laurent Spinelli Francesca Pittau Andrea Bartoli Shahan Momjian Raffaele Manni Michele Terzaghi Serge Vulliemoz Margitta Seeck |
| author_sort | Gianpaolo Toscano |
| collection | DOAJ |
| description | Objective: In this study, we sought to determine whether visual analysis of high density EEG (HD-EEG) would provide similar localizing information comparable to electrical source imaging (ESI). Methods: HD-EEG (256 electrodes) recordings from 20 patients suffering from unifocal, drug-resistant epilepsy (13 women, mean age 29.1 ± 2.62 years, 11 with temporal lobe epilepsy) were examined. In the visual analysis condition, we identified the 5 contacts with maximal spike amplitude and determined their localization with respect to the underlying cortex. ESI was computed using the LAURA algorithm of the averaged spikes in the patient’s individual MRI. We considered the localization “correct” if all 5 contacts were concordant with the resection volume underneath or if ESI was located within the resection as determined by the postoperative MRI. Results: Twelve patients were postoperatively seizure-free (Engel Class IA), while the remaining eight were in class IB to IV. Visual analysis and ESI showed sensitivity of 58% and 75%, specificity of 75% and 87%, and accuracy of 65% and 80%, respectively. In 70% of cases, visual analysis and ESI provided concordant results. Conclusions: Localization of the electrodes with maximal spike amplitude provides very good estimation of the localization of the underlying source. However, ESI has a higher accuracy and adds 3D information; therefore, it should remain the tool of choice for presurgical evaluation. Significance: The present study proposes the possibility to analyze HD-EEG visually, in tandem with ESI or alone, if ESI is not accessible. |
| first_indexed | 2024-12-19T03:46:29Z |
| format | Article |
| id | doaj.art-cf9400957ec94092a36de8448afadb49 |
| institution | Directory Open Access Journal |
| issn | 2467-981X |
| language | English |
| last_indexed | 2024-12-19T03:46:29Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Clinical Neurophysiology Practice |
| spelling | doaj.art-cf9400957ec94092a36de8448afadb492022-12-21T20:37:07ZengElsevierClinical Neurophysiology Practice2467-981X2020-01-0151622Visual analysis of high density EEG: As good as electrical source imaging?Gianpaolo Toscano0Margherita Carboni1Maria Rubega2Laurent Spinelli3Francesca Pittau4Andrea Bartoli5Shahan Momjian6Raffaele Manni7Michele Terzaghi8Serge Vulliemoz9Margitta Seeck10EEG and Epilepsy Unit, University Hospital of Geneva, Geneva, Switzerland; Unit of Sleep Medicine and Epilepsy, IRCCS Mondino Foundation, Pavia, Italy; Department of Brain and Behavioural Sciences, University of Pavia, Italy; Corresponding author at: Unit of Sleep Medicine and Epilepsy, IRCCS Mondino Foundation, Via Mondino 2, 27100 Pavia, Italy.EEG and Epilepsy Unit, University Hospital of Geneva, Geneva, Switzerland; Functional Brain Mapping Lab, Department of Fundamental Neurosciences, University of Geneva, Geneva, SwitzerlandFunctional Brain Mapping Lab, Department of Fundamental Neurosciences, University of Geneva, Geneva, SwitzerlandEEG and Epilepsy Unit, University Hospital of Geneva, Geneva, SwitzerlandEEG and Epilepsy Unit, University Hospital of Geneva, Geneva, SwitzerlandDepartment of Neurosurgery, University Hospital of Geneva, Geneva, SwitzerlandDepartment of Neurosurgery, University Hospital of Geneva, Geneva, SwitzerlandUnit of Sleep Medicine and Epilepsy, IRCCS Mondino Foundation, Pavia, ItalyUnit of Sleep Medicine and Epilepsy, IRCCS Mondino Foundation, Pavia, Italy; Department of Brain and Behavioural Sciences, University of Pavia, ItalyEEG and Epilepsy Unit, University Hospital of Geneva, Geneva, SwitzerlandEEG and Epilepsy Unit, University Hospital of Geneva, Geneva, SwitzerlandObjective: In this study, we sought to determine whether visual analysis of high density EEG (HD-EEG) would provide similar localizing information comparable to electrical source imaging (ESI). Methods: HD-EEG (256 electrodes) recordings from 20 patients suffering from unifocal, drug-resistant epilepsy (13 women, mean age 29.1 ± 2.62 years, 11 with temporal lobe epilepsy) were examined. In the visual analysis condition, we identified the 5 contacts with maximal spike amplitude and determined their localization with respect to the underlying cortex. ESI was computed using the LAURA algorithm of the averaged spikes in the patient’s individual MRI. We considered the localization “correct” if all 5 contacts were concordant with the resection volume underneath or if ESI was located within the resection as determined by the postoperative MRI. Results: Twelve patients were postoperatively seizure-free (Engel Class IA), while the remaining eight were in class IB to IV. Visual analysis and ESI showed sensitivity of 58% and 75%, specificity of 75% and 87%, and accuracy of 65% and 80%, respectively. In 70% of cases, visual analysis and ESI provided concordant results. Conclusions: Localization of the electrodes with maximal spike amplitude provides very good estimation of the localization of the underlying source. However, ESI has a higher accuracy and adds 3D information; therefore, it should remain the tool of choice for presurgical evaluation. Significance: The present study proposes the possibility to analyze HD-EEG visually, in tandem with ESI or alone, if ESI is not accessible.http://www.sciencedirect.com/science/article/pii/S2467981X1930040XHigh density EEGEpilepsy surgerySource analysisFocus localizationMRIElectric source imaging |
| spellingShingle | Gianpaolo Toscano Margherita Carboni Maria Rubega Laurent Spinelli Francesca Pittau Andrea Bartoli Shahan Momjian Raffaele Manni Michele Terzaghi Serge Vulliemoz Margitta Seeck Visual analysis of high density EEG: As good as electrical source imaging? Clinical Neurophysiology Practice High density EEG Epilepsy surgery Source analysis Focus localization MRI Electric source imaging |
| title | Visual analysis of high density EEG: As good as electrical source imaging? |
| title_full | Visual analysis of high density EEG: As good as electrical source imaging? |
| title_fullStr | Visual analysis of high density EEG: As good as electrical source imaging? |
| title_full_unstemmed | Visual analysis of high density EEG: As good as electrical source imaging? |
| title_short | Visual analysis of high density EEG: As good as electrical source imaging? |
| title_sort | visual analysis of high density eeg as good as electrical source imaging |
| topic | High density EEG Epilepsy surgery Source analysis Focus localization MRI Electric source imaging |
| url | http://www.sciencedirect.com/science/article/pii/S2467981X1930040X |
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