Comparison of the Transdermal and Intravenous Administration of Buprenorphine in the Management of Intra- and Postoperative Pain in Dogs Undergoing a Unilateral Mastectomy
The aim of this prospective clinical study was to evaluate the effectiveness of transdermal patches of buprenorphine as an alternative route for the management of perioperative pain in dogs undergoing a unilateral mastectomy. Our hypothesis was that the transdermal route would allow the obtainment o...
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MDPI AG
2022-12-01
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| Online Access: | https://www.mdpi.com/2076-2615/12/24/3468 |
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| author | Margherita Galosi Alessandro Troisi Pietro Toniolo Luca Pennasilico Vincenzo Cicirelli Angela Palumbo Piccionello Caterina Di Bella |
| author_facet | Margherita Galosi Alessandro Troisi Pietro Toniolo Luca Pennasilico Vincenzo Cicirelli Angela Palumbo Piccionello Caterina Di Bella |
| author_sort | Margherita Galosi |
| collection | DOAJ |
| description | The aim of this prospective clinical study was to evaluate the effectiveness of transdermal patches of buprenorphine as an alternative route for the management of perioperative pain in dogs undergoing a unilateral mastectomy. Our hypothesis was that the transdermal route would allow the obtainment of an analgesic plan comparable to that of the injectable administration. Twelve dogs were divided in two groups. In the BupreP group (six dogs), buprenorphine patches were applied 40 h before the start of the surgery, guaranteeing a dosage of 5–6 μg/kg/h. In the BupreI group (six dogs), 20 μg/kg of buprenorphine was administered intravenously 30 min before the induction of anesthesia, and this was repeated every 6 h for 24 h. The main physiological parameters, sedation scores (0 = no sedation; 11 = deep sedation), and pain scores were monitored from 30 min before the surgery to 24 h after the end of anesthesia. All <i>p</i> values < 0.05 were defined as statistically significant. Thirty minutes before the surgery, the sedation scores were higher in BupreI (score = 10) compared to the BupreP group (score = 1). Moreover, during the mastectomy, the mean arterial pressure significantly increased in both groups even if nobody required additional analgesia. In the postoperative period, the pain scores did not show statistically significant differences between the two groups, maintaining values below the pain threshold at all times of the study. In conclusion, the transdermal administration of buprenorphine could guarantee an analgesic quality equal to that of the injectable route. |
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| language | English |
| last_indexed | 2024-03-09T17:25:19Z |
| publishDate | 2022-12-01 |
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| record_format | Article |
| series | Animals |
| spelling | doaj.art-cf94881a194742f6802b9132abe035b92023-11-24T12:50:14ZengMDPI AGAnimals2076-26152022-12-011224346810.3390/ani12243468Comparison of the Transdermal and Intravenous Administration of Buprenorphine in the Management of Intra- and Postoperative Pain in Dogs Undergoing a Unilateral MastectomyMargherita Galosi0Alessandro Troisi1Pietro Toniolo2Luca Pennasilico3Vincenzo Cicirelli4Angela Palumbo Piccionello5Caterina Di Bella6School of Bioscience and Veterinary Medicine, University of Camerino, 62024 Matelica, ItalySchool of Bioscience and Veterinary Medicine, University of Camerino, 62024 Matelica, ItalySchool of Bioscience and Veterinary Medicine, University of Camerino, 62024 Matelica, ItalySchool of Bioscience and Veterinary Medicine, University of Camerino, 62024 Matelica, ItalyDepartment of Veterinary Medicine (DMV), University of Bari Aldo Moro, 70010 Valenzano, ItalySchool of Bioscience and Veterinary Medicine, University of Camerino, 62024 Matelica, ItalySchool of Bioscience and Veterinary Medicine, University of Camerino, 62024 Matelica, ItalyThe aim of this prospective clinical study was to evaluate the effectiveness of transdermal patches of buprenorphine as an alternative route for the management of perioperative pain in dogs undergoing a unilateral mastectomy. Our hypothesis was that the transdermal route would allow the obtainment of an analgesic plan comparable to that of the injectable administration. Twelve dogs were divided in two groups. In the BupreP group (six dogs), buprenorphine patches were applied 40 h before the start of the surgery, guaranteeing a dosage of 5–6 μg/kg/h. In the BupreI group (six dogs), 20 μg/kg of buprenorphine was administered intravenously 30 min before the induction of anesthesia, and this was repeated every 6 h for 24 h. The main physiological parameters, sedation scores (0 = no sedation; 11 = deep sedation), and pain scores were monitored from 30 min before the surgery to 24 h after the end of anesthesia. All <i>p</i> values < 0.05 were defined as statistically significant. Thirty minutes before the surgery, the sedation scores were higher in BupreI (score = 10) compared to the BupreP group (score = 1). Moreover, during the mastectomy, the mean arterial pressure significantly increased in both groups even if nobody required additional analgesia. In the postoperative period, the pain scores did not show statistically significant differences between the two groups, maintaining values below the pain threshold at all times of the study. In conclusion, the transdermal administration of buprenorphine could guarantee an analgesic quality equal to that of the injectable route.https://www.mdpi.com/2076-2615/12/24/3468mastectomypainbuprenorphinetransdermal patchesdog |
| spellingShingle | Margherita Galosi Alessandro Troisi Pietro Toniolo Luca Pennasilico Vincenzo Cicirelli Angela Palumbo Piccionello Caterina Di Bella Comparison of the Transdermal and Intravenous Administration of Buprenorphine in the Management of Intra- and Postoperative Pain in Dogs Undergoing a Unilateral Mastectomy Animals mastectomy pain buprenorphine transdermal patches dog |
| title | Comparison of the Transdermal and Intravenous Administration of Buprenorphine in the Management of Intra- and Postoperative Pain in Dogs Undergoing a Unilateral Mastectomy |
| title_full | Comparison of the Transdermal and Intravenous Administration of Buprenorphine in the Management of Intra- and Postoperative Pain in Dogs Undergoing a Unilateral Mastectomy |
| title_fullStr | Comparison of the Transdermal and Intravenous Administration of Buprenorphine in the Management of Intra- and Postoperative Pain in Dogs Undergoing a Unilateral Mastectomy |
| title_full_unstemmed | Comparison of the Transdermal and Intravenous Administration of Buprenorphine in the Management of Intra- and Postoperative Pain in Dogs Undergoing a Unilateral Mastectomy |
| title_short | Comparison of the Transdermal and Intravenous Administration of Buprenorphine in the Management of Intra- and Postoperative Pain in Dogs Undergoing a Unilateral Mastectomy |
| title_sort | comparison of the transdermal and intravenous administration of buprenorphine in the management of intra and postoperative pain in dogs undergoing a unilateral mastectomy |
| topic | mastectomy pain buprenorphine transdermal patches dog |
| url | https://www.mdpi.com/2076-2615/12/24/3468 |
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