Neurophysiological mechanisms of cancer-induced bone pain
Background: Cancer-induced Bone Pain (CIBP) is an important factor affecting their quality of life of cancer survivors. In addition, current clinical practice and scientific research suggest that neuropathic pain is a representative component of CIBP. However, given the variability of cancer conditi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Journal of Advanced Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2090123221001028 |
| _version_ | 1818969636866097152 |
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| author | Xuan-Qi Zheng Yu-hao Wu Jin-feng Huang Ai-Min Wu |
| author_facet | Xuan-Qi Zheng Yu-hao Wu Jin-feng Huang Ai-Min Wu |
| author_sort | Xuan-Qi Zheng |
| collection | DOAJ |
| description | Background: Cancer-induced Bone Pain (CIBP) is an important factor affecting their quality of life of cancer survivors. In addition, current clinical practice and scientific research suggest that neuropathic pain is a representative component of CIBP. However, given the variability of cancer conditions and the complexity of neuropathic pain, related mechanisms have been continuously supplemented but have not been perfected. Aim of Review: Therefore, the current review highlights the latest progress in basic research on the field and proposes potential therapeutic targets, representative drugs and upcoming therapies. Key Scientific Concepts of Review: Notably, factors such as central sensitization, neuroinflammation, glial cell activation and an acidic environment are considered to be related to neuropathic pain in CIBP. Nonetheless, further research is needed to ascertain the mechanism of CIBP in order to develop highly effective drugs. Moreover, more attention needs to be paid to the care of patients with advanced cancer. |
| first_indexed | 2024-12-20T14:23:44Z |
| format | Article |
| id | doaj.art-cf95df803cba42efb0a2438d1d242940 |
| institution | Directory Open Access Journal |
| issn | 2090-1232 |
| language | English |
| last_indexed | 2024-12-20T14:23:44Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Advanced Research |
| spelling | doaj.art-cf95df803cba42efb0a2438d1d2429402022-12-21T19:37:51ZengElsevierJournal of Advanced Research2090-12322022-01-0135117127Neurophysiological mechanisms of cancer-induced bone painXuan-Qi Zheng0Yu-hao Wu1Jin-feng Huang2Ai-Min Wu3Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Zhejiang Provincial Key Laboratory of Orthopaedics, Wenzhou, Zhejiang, 325027, China; Wenzhou Medical University, Wenzhou, Zhejiang, 325027, ChinaWenzhou Medical University, Wenzhou, Zhejiang, 325027, ChinaDepartment of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Zhejiang Provincial Key Laboratory of Orthopaedics, Wenzhou, Zhejiang, 325027, China; Wenzhou Medical University, Wenzhou, Zhejiang, 325027, ChinaDepartment of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Zhejiang Provincial Key Laboratory of Orthopaedics, Wenzhou, Zhejiang, 325027, China; Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China; Corresponding author at: Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Zhejiang Provincial Key Laboratory of Orthopaedics, Wenzhou, Zhejiang, 325027, China.Background: Cancer-induced Bone Pain (CIBP) is an important factor affecting their quality of life of cancer survivors. In addition, current clinical practice and scientific research suggest that neuropathic pain is a representative component of CIBP. However, given the variability of cancer conditions and the complexity of neuropathic pain, related mechanisms have been continuously supplemented but have not been perfected. Aim of Review: Therefore, the current review highlights the latest progress in basic research on the field and proposes potential therapeutic targets, representative drugs and upcoming therapies. Key Scientific Concepts of Review: Notably, factors such as central sensitization, neuroinflammation, glial cell activation and an acidic environment are considered to be related to neuropathic pain in CIBP. Nonetheless, further research is needed to ascertain the mechanism of CIBP in order to develop highly effective drugs. Moreover, more attention needs to be paid to the care of patients with advanced cancer.http://www.sciencedirect.com/science/article/pii/S2090123221001028Cancer-induced bone painCentral sensitizationNeuroinflammationAcidic environmentTRPVP2X Family |
| spellingShingle | Xuan-Qi Zheng Yu-hao Wu Jin-feng Huang Ai-Min Wu Neurophysiological mechanisms of cancer-induced bone pain Journal of Advanced Research Cancer-induced bone pain Central sensitization Neuroinflammation Acidic environment TRPV P2X Family |
| title | Neurophysiological mechanisms of cancer-induced bone pain |
| title_full | Neurophysiological mechanisms of cancer-induced bone pain |
| title_fullStr | Neurophysiological mechanisms of cancer-induced bone pain |
| title_full_unstemmed | Neurophysiological mechanisms of cancer-induced bone pain |
| title_short | Neurophysiological mechanisms of cancer-induced bone pain |
| title_sort | neurophysiological mechanisms of cancer induced bone pain |
| topic | Cancer-induced bone pain Central sensitization Neuroinflammation Acidic environment TRPV P2X Family |
| url | http://www.sciencedirect.com/science/article/pii/S2090123221001028 |
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