Validation of brain parenchyma sonography as a marker of neurodegeneration in multiple sclerosis
Abstract Background Multiple sclerosis (MS) is widely known to cause brain atrophy due to neurodegeneration. Neuroimaging investigations revealed a direct link between brain atrophy detected by MRI and impairment. Transcranial sonography is a safe, feasible and cost-effective imaging technique. In t...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2023-10-01
|
| Series: | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s41983-023-00732-5 |
| _version_ | 1797577404987736064 |
|---|---|
| author | Nirmeen A. Kishk Sherif Hamdy Hanan Amer Nevin M. Shalaby Alshimaa S. Othman Mohammad Edrees Mohammad |
| author_facet | Nirmeen A. Kishk Sherif Hamdy Hanan Amer Nevin M. Shalaby Alshimaa S. Othman Mohammad Edrees Mohammad |
| author_sort | Nirmeen A. Kishk |
| collection | DOAJ |
| description | Abstract Background Multiple sclerosis (MS) is widely known to cause brain atrophy due to neurodegeneration. Neuroimaging investigations revealed a direct link between brain atrophy detected by MRI and impairment. Transcranial sonography is a safe, feasible and cost-effective imaging technique. In this study, we aimed to validate B-mode transcranial sonography (TCS) as a marker of neurodegeneration in MS. This study is the first study directed to set cut-off point for brain parenchyma measurement in Egyptian population. An observational, case–control study, conducted on 125 subjects; divided into 2 groups: first group, 71 healthy volunteers and patients’ group (54 patients) with relapsing–remitting multiple sclerosis (RRMS). All studied subjects were assessed using B-mode TCS. Transcranial sonography findings were categorized into: first, assessment of brain atrophy parameters by measuring diameter (cm) of third ventricle and both frontal horns of lateral ventricles. Then, the echogenicity of thalamus and brainstem structures (substantia nigra (SN), red nucleus) planimetric surface area (cm2) were assessed along with their abnormal echogenicity (cm2), while brainstem raphe was assessed semi-quantitatively for its echogenicity (intact or interrupted). Results Quantitative measures of brain atrophy: in normal control group the third ventricle diameter mean was 0.2 cm (± 0.08), right and left frontal horn diameter were 0.3 cm (± 0.13) and 0.28 cm (± 0.1), respectively, brain atrophy parameters could differentiate between MS patients and normal control group as a statistically significant (p< 0.001) larger ventricular diameter was found in MS patients. On the other hand, assessment of brain stem structures and thalamus showed no statistical significance between MS patients and normal control except in surface area of both red nuclei. Conclusions Brain parenchymal sonography may be used as a tool in assessment of neurodegeneration in MS patients. |
| first_indexed | 2024-03-10T22:07:48Z |
| format | Article |
| id | doaj.art-cf960fc521f64f40bc766d260ee3210b |
| institution | Directory Open Access Journal |
| issn | 1687-8329 |
| language | English |
| last_indexed | 2024-03-10T22:07:48Z |
| publishDate | 2023-10-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
| spelling | doaj.art-cf960fc521f64f40bc766d260ee3210b2023-11-19T12:44:38ZengSpringerOpenThe Egyptian Journal of Neurology, Psychiatry and Neurosurgery1687-83292023-10-015911910.1186/s41983-023-00732-5Validation of brain parenchyma sonography as a marker of neurodegeneration in multiple sclerosisNirmeen A. Kishk0Sherif Hamdy1Hanan Amer2Nevin M. Shalaby3Alshimaa S. Othman4Mohammad Edrees Mohammad5Department of Neurology, Faculty of Medicine, Cairo UniversityDepartment of Neurology, Faculty of Medicine, Cairo UniversityDepartment of Neurology, Faculty of Medicine, Cairo UniversityDepartment of Neurology, Faculty of Medicine, Cairo UniversityDepartment of Neurology, Faculty of Medicine, Cairo UniversityDepartment of Neurology, Faculty of Medicine, Cairo UniversityAbstract Background Multiple sclerosis (MS) is widely known to cause brain atrophy due to neurodegeneration. Neuroimaging investigations revealed a direct link between brain atrophy detected by MRI and impairment. Transcranial sonography is a safe, feasible and cost-effective imaging technique. In this study, we aimed to validate B-mode transcranial sonography (TCS) as a marker of neurodegeneration in MS. This study is the first study directed to set cut-off point for brain parenchyma measurement in Egyptian population. An observational, case–control study, conducted on 125 subjects; divided into 2 groups: first group, 71 healthy volunteers and patients’ group (54 patients) with relapsing–remitting multiple sclerosis (RRMS). All studied subjects were assessed using B-mode TCS. Transcranial sonography findings were categorized into: first, assessment of brain atrophy parameters by measuring diameter (cm) of third ventricle and both frontal horns of lateral ventricles. Then, the echogenicity of thalamus and brainstem structures (substantia nigra (SN), red nucleus) planimetric surface area (cm2) were assessed along with their abnormal echogenicity (cm2), while brainstem raphe was assessed semi-quantitatively for its echogenicity (intact or interrupted). Results Quantitative measures of brain atrophy: in normal control group the third ventricle diameter mean was 0.2 cm (± 0.08), right and left frontal horn diameter were 0.3 cm (± 0.13) and 0.28 cm (± 0.1), respectively, brain atrophy parameters could differentiate between MS patients and normal control group as a statistically significant (p< 0.001) larger ventricular diameter was found in MS patients. On the other hand, assessment of brain stem structures and thalamus showed no statistical significance between MS patients and normal control except in surface area of both red nuclei. Conclusions Brain parenchymal sonography may be used as a tool in assessment of neurodegeneration in MS patients.https://doi.org/10.1186/s41983-023-00732-5Transcranial sonographyVentriclesNeurodegenerationBrain stemEchogenicityMultiple sclerosis |
| spellingShingle | Nirmeen A. Kishk Sherif Hamdy Hanan Amer Nevin M. Shalaby Alshimaa S. Othman Mohammad Edrees Mohammad Validation of brain parenchyma sonography as a marker of neurodegeneration in multiple sclerosis The Egyptian Journal of Neurology, Psychiatry and Neurosurgery Transcranial sonography Ventricles Neurodegeneration Brain stem Echogenicity Multiple sclerosis |
| title | Validation of brain parenchyma sonography as a marker of neurodegeneration in multiple sclerosis |
| title_full | Validation of brain parenchyma sonography as a marker of neurodegeneration in multiple sclerosis |
| title_fullStr | Validation of brain parenchyma sonography as a marker of neurodegeneration in multiple sclerosis |
| title_full_unstemmed | Validation of brain parenchyma sonography as a marker of neurodegeneration in multiple sclerosis |
| title_short | Validation of brain parenchyma sonography as a marker of neurodegeneration in multiple sclerosis |
| title_sort | validation of brain parenchyma sonography as a marker of neurodegeneration in multiple sclerosis |
| topic | Transcranial sonography Ventricles Neurodegeneration Brain stem Echogenicity Multiple sclerosis |
| url | https://doi.org/10.1186/s41983-023-00732-5 |
| work_keys_str_mv | AT nirmeenakishk validationofbrainparenchymasonographyasamarkerofneurodegenerationinmultiplesclerosis AT sherifhamdy validationofbrainparenchymasonographyasamarkerofneurodegenerationinmultiplesclerosis AT hananamer validationofbrainparenchymasonographyasamarkerofneurodegenerationinmultiplesclerosis AT nevinmshalaby validationofbrainparenchymasonographyasamarkerofneurodegenerationinmultiplesclerosis AT alshimaasothman validationofbrainparenchymasonographyasamarkerofneurodegenerationinmultiplesclerosis AT mohammadedreesmohammad validationofbrainparenchymasonographyasamarkerofneurodegenerationinmultiplesclerosis |