HMGB1/autophagy pathway mediates the atrophic effect of TGF-β1 in denervated skeletal muscle

HMGB1/autophagy pathway mediates the atrophic effect of TGF-β1 in denervated skeletal muscle

Abstract Background Transforming growth factor beta 1 (TGF-β1) is a classical modulator of skeletal muscle and regulates several processes, such as myogenesis, regeneration and muscle function in skeletal muscle diseases. Skeletal muscle atrophy, characterized by the loss of muscle strength and mass...

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Bibliographic Details
Main Authors: Xiaofan Yang, Pingping Xue, Xin Liu, Xiang Xu, Zhenbing Chen
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Cell Communication and Signaling
Subjects:
Denervation
Skeletal muscle
Atrophy
TGF-β1
HMGB1
Autophagy
Online Access:http://link.springer.com/article/10.1186/s12964-018-0310-6

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