Tissue engineering approaches for the construction of a completely autologous tendon substitute
Tissue engineering is a multidisciplinary field that involves the application of the principles and methods of engineering and life sciences towards i) the fundamental understanding of structure-function relationships in normal and pathological mammalian tissues and ii) the development of biological...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Thieme Medical Publishers, Inc.
2008-01-01
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| Series: | Indian Journal of Plastic Surgery |
| Subjects: | |
| Online Access: | http://www.ijps.org/article.asp?issn=0970-0358;year=2008;volume=41;issue=1;spage=38;epage=46;aulast=Bassetto |
| Summary: | Tissue engineering is a multidisciplinary field that involves the application of the principles and methods of engineering and life sciences towards i) the fundamental understanding of structure-function relationships in normal and pathological mammalian tissues and ii) the development of biological substitutes that restore, maintain or improve tissue function. The goal of tissue engineering is to surpass the limitations of conventional treatments based on organ transplantation and biomaterial implantation. The field of tendon tissue engineering is relatively unexplored due to the difficulty in <i> in vitro</i> preservation of tenocyte phenotype. Only recently has mechanobiology allowed us to gain a better understanding of the fundamental role of <i> in vitro</i> mechanical stimuli in maintaining the phenotype of tendinous tissue. This review analyzes the techniques used so far for <i> in vitro</i> regeneration of tendinous tissue. |
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| ISSN: | 0970-0358 1998-376X |