Epithelial Histone Deacetylase 3 Instructs Intestinal Immunity by Coordinating Local Lymphocyte Activation

Epithelial Histone Deacetylase 3 Instructs Intestinal Immunity by Coordinating Local Lymphocyte Activation

Mucosal tissues are constantly in direct contact with diverse beneficial and pathogenic microbes, highlighting the need for orchestrating complex microbial signals to sustain effective host defense. Here, we show an essential role for intestinal epithelial cell expression of histone deacetylase 3 (H...

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Bibliographic Details
Main Authors: Nazanin Navabi, Jordan Whitt, Shu-en Wu, Vivienne Woo, Jessica Moncivaiz, Michael B. Jordan, Bruce A. Vallance, Sing Sing Way, Theresa Alenghat
Format: Article
Language:English
Published: Elsevier 2017-05-01
Series:Cell Reports
Subjects:
infection
intestine
microbiota
HDAC3
epigenetic
mucosal immunology
epithelial
defense
innate
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717305405

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