Morphine disinhibits glutamatergic input to VTA dopamine neurons and promotes dopamine neuron excitation

Morphine disinhibits glutamatergic input to VTA dopamine neurons and promotes dopamine neuron excitation

One reported mechanism for morphine activation of dopamine (DA) neurons of the ventral tegmental area (VTA) is the disinhibition model of VTA-DA neurons. Morphine inhibits GABA inhibitory neurons, which shifts the balance between inhibitory and excitatory input to VTA-DA neurons in favor of excitati...

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Bibliographic Details
Main Authors: Ming Chen, Yanfang Zhao, Hualan Yang, Wenjie Luan, Jiaojiao Song, Dongyang Cui, Yi Dong, Bin Lai, Lan Ma, Ping Zheng
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-07-01
Series:eLife
Subjects:
dopamine neuron
GABA neuron
GABAB receptor
glutamate release
morphine
ventral tegmental area
Online Access:https://elifesciences.org/articles/09275

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