Natural flavonoids: Potential therapeutic strategies for non-alcoholic fatty liver disease
The incidence of non-alcoholic fatty liver disease (NAFLD) is increasing rapidly worldwide; however, there are currently limited treatments for NAFLD. The disease spectrum includes simple fatty liver, non-alcoholic steatohepatitis (NASH), fibrosis, cirrhosis, and progression to hepatocellular carcin...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.1005312/full |
| _version_ | 1828145054877745152 |
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| author | Panli Tan Li Jin Xiang Qin Beihui He |
| author_facet | Panli Tan Li Jin Xiang Qin Beihui He |
| author_sort | Panli Tan |
| collection | DOAJ |
| description | The incidence of non-alcoholic fatty liver disease (NAFLD) is increasing rapidly worldwide; however, there are currently limited treatments for NAFLD. The disease spectrum includes simple fatty liver, non-alcoholic steatohepatitis (NASH), fibrosis, cirrhosis, and progression to hepatocellular carcinoma (NASH-HCC). The therapeutic effects of NAFLD remain controversial. Although researchers have conducted studies on the pathogenesis of NAFLD, its pathogenesis and anti-NAFLD mechanisms have not been fully elucidated. Previous studies have found that flavonoids, as natural substances with extensive pharmacological activity and good therapeutic effects, have excellent antioxidant, anti-inflammatory, metabolic disease improvement, anti-tumor, and other properties and can significantly alleviate NAFLD. Flavonoids could be further developed as therapeutic drugs for NAFLD. In this paper, the pathogenesis of NAFLD and the mechanisms of flavonoids against NAFLD are summarized to provide a theoretical basis for screening flavonoids against non-alcoholic liver injury. |
| first_indexed | 2024-04-11T20:26:26Z |
| format | Article |
| id | doaj.art-cf9dc4a60bd44061ae549db07a14a151 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-11T20:26:26Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-cf9dc4a60bd44061ae549db07a14a1512022-12-22T04:04:39ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-09-011310.3389/fphar.2022.10053121005312Natural flavonoids: Potential therapeutic strategies for non-alcoholic fatty liver diseasePanli Tan0Li Jin1Xiang Qin2Beihui He3The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, ChinaSchool of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, ChinaThe First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, ChinaThe First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, ChinaThe incidence of non-alcoholic fatty liver disease (NAFLD) is increasing rapidly worldwide; however, there are currently limited treatments for NAFLD. The disease spectrum includes simple fatty liver, non-alcoholic steatohepatitis (NASH), fibrosis, cirrhosis, and progression to hepatocellular carcinoma (NASH-HCC). The therapeutic effects of NAFLD remain controversial. Although researchers have conducted studies on the pathogenesis of NAFLD, its pathogenesis and anti-NAFLD mechanisms have not been fully elucidated. Previous studies have found that flavonoids, as natural substances with extensive pharmacological activity and good therapeutic effects, have excellent antioxidant, anti-inflammatory, metabolic disease improvement, anti-tumor, and other properties and can significantly alleviate NAFLD. Flavonoids could be further developed as therapeutic drugs for NAFLD. In this paper, the pathogenesis of NAFLD and the mechanisms of flavonoids against NAFLD are summarized to provide a theoretical basis for screening flavonoids against non-alcoholic liver injury.https://www.frontiersin.org/articles/10.3389/fphar.2022.1005312/fullnon-alcoholic fatty liver diseasenatural flavonoids, antioxidant, anti-inflammatoryintestinal floraoxidat ive stressinflammtion |
| spellingShingle | Panli Tan Li Jin Xiang Qin Beihui He Natural flavonoids: Potential therapeutic strategies for non-alcoholic fatty liver disease Frontiers in Pharmacology non-alcoholic fatty liver disease natural flavonoids, antioxidant, anti-inflammatory intestinal flora oxidat ive stress inflammtion |
| title | Natural flavonoids: Potential therapeutic strategies for non-alcoholic fatty liver disease |
| title_full | Natural flavonoids: Potential therapeutic strategies for non-alcoholic fatty liver disease |
| title_fullStr | Natural flavonoids: Potential therapeutic strategies for non-alcoholic fatty liver disease |
| title_full_unstemmed | Natural flavonoids: Potential therapeutic strategies for non-alcoholic fatty liver disease |
| title_short | Natural flavonoids: Potential therapeutic strategies for non-alcoholic fatty liver disease |
| title_sort | natural flavonoids potential therapeutic strategies for non alcoholic fatty liver disease |
| topic | non-alcoholic fatty liver disease natural flavonoids, antioxidant, anti-inflammatory intestinal flora oxidat ive stress inflammtion |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.1005312/full |
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