A Src-like inactive conformation in the abl tyrosine kinase domain.

A Src-like inactive conformation in the abl tyrosine kinase domain.

The improper activation of the Abl tyrosine kinase results in chronic myeloid leukemia (CML). The recognition of an inactive conformation of Abl, in which a catalytically important Asp-Phe-Gly (DFG) motif is flipped by approximately 180 degrees with respect to the active conformation, underlies the...

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Bibliographic Details
Main Authors: Nicholas M Levinson, Olga Kuchment, Kui Shen, Matthew A Young, Michael Koldobskiy, Martin Karplus, Philip A Cole, John Kuriyan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2006-05-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC1450098?pdf=render

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