Impact of Coronary Plaque Vulnerability on Acute Cardiovascular Events – Design of a CT-based 2-year Follow-up Study
With coronary artery disease (CAD) projected to remain the leading cause of global mortality, prevention strategies seem to be the only effective approach able to reduce the burden and improve mortality and morbidity. At this moment, diagnostic strategies focus mainly on symptomatic patients, ignori...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2019-06-01
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| Series: | Journal of Interdisciplinary Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.2478/jim-2019-0015 |
| _version_ | 1818678180757635072 |
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| author | Mitra Noémi Hodas Roxana Szabó Evelin Parajkó Zsolt Benedek Theodora Benedek Imre |
| author_facet | Mitra Noémi Hodas Roxana Szabó Evelin Parajkó Zsolt Benedek Theodora Benedek Imre |
| author_sort | Mitra Noémi |
| collection | DOAJ |
| description | With coronary artery disease (CAD) projected to remain the leading cause of global mortality, prevention strategies seem to be the only effective approach able to reduce the burden and improve mortality and morbidity. At this moment, diagnostic strategies focus mainly on symptomatic patients, ignoring the occurrence of major cardiovascular events as the only manifestation of CAD. As two thirds of fatal myocardial infarction are resulting from plaque rupture, an approach based on the “vulnerable plaque” concept is mandatory in order to improve patient diagnosis, treatment, and, by default, prognosis. Given that the main studies focus on a plaque-centered approach, this is a prospective observational study that will perform a complex assessment of the features that characterize unstable coronary lesions, in terms of both local assessment via specific coronary computed tomography angiography markers of coronary plaque vulnerability and systemic approach based on serological markers of systemic inflammation in patients proved to be “vulnerable” by developing acute cardiovascular events. |
| first_indexed | 2024-12-17T09:11:10Z |
| format | Article |
| id | doaj.art-cf9f1ccbf5ad47ccb534936e7430c77d |
| institution | Directory Open Access Journal |
| issn | 2501-8132 |
| language | English |
| last_indexed | 2024-12-17T09:11:10Z |
| publishDate | 2019-06-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Journal of Interdisciplinary Medicine |
| spelling | doaj.art-cf9f1ccbf5ad47ccb534936e7430c77d2022-12-21T21:55:13ZengSciendoJournal of Interdisciplinary Medicine2501-81322019-06-0142647110.2478/jim-2019-0015jim-2019-0015Impact of Coronary Plaque Vulnerability on Acute Cardiovascular Events – Design of a CT-based 2-year Follow-up StudyMitra Noémi0Hodas Roxana1Szabó Evelin2Parajkó Zsolt3Benedek Theodora4Benedek Imre5Center of Advanced Research in Multimodality Cardiac Imaging, Cardio Med Medical Center, Târgu Mureş, RomaniaUniversity of Medicine, Pharmacy, Science and Technology, Târgu Mureş, RomaniaCenter of Advanced Research in Multimodality Cardiac Imaging, Cardio Med Medical Center, Târgu Mureş, RomaniaCenter of Advanced Research in Multimodality Cardiac Imaging, Cardio Med Medical Center, Târgu Mureş, RomaniaUniversity of Medicine, Pharmacy, Science and Technology, Târgu Mureş, RomaniaUniversity of Medicine, Pharmacy, Science and Technology, Târgu Mureş, RomaniaWith coronary artery disease (CAD) projected to remain the leading cause of global mortality, prevention strategies seem to be the only effective approach able to reduce the burden and improve mortality and morbidity. At this moment, diagnostic strategies focus mainly on symptomatic patients, ignoring the occurrence of major cardiovascular events as the only manifestation of CAD. As two thirds of fatal myocardial infarction are resulting from plaque rupture, an approach based on the “vulnerable plaque” concept is mandatory in order to improve patient diagnosis, treatment, and, by default, prognosis. Given that the main studies focus on a plaque-centered approach, this is a prospective observational study that will perform a complex assessment of the features that characterize unstable coronary lesions, in terms of both local assessment via specific coronary computed tomography angiography markers of coronary plaque vulnerability and systemic approach based on serological markers of systemic inflammation in patients proved to be “vulnerable” by developing acute cardiovascular events.https://doi.org/10.2478/jim-2019-0015vulnerable plaqueacute cardiovascular eventsystemic inflammationvulnerability markers |
| spellingShingle | Mitra Noémi Hodas Roxana Szabó Evelin Parajkó Zsolt Benedek Theodora Benedek Imre Impact of Coronary Plaque Vulnerability on Acute Cardiovascular Events – Design of a CT-based 2-year Follow-up Study Journal of Interdisciplinary Medicine vulnerable plaque acute cardiovascular event systemic inflammation vulnerability markers |
| title | Impact of Coronary Plaque Vulnerability on Acute Cardiovascular Events – Design of a CT-based 2-year Follow-up Study |
| title_full | Impact of Coronary Plaque Vulnerability on Acute Cardiovascular Events – Design of a CT-based 2-year Follow-up Study |
| title_fullStr | Impact of Coronary Plaque Vulnerability on Acute Cardiovascular Events – Design of a CT-based 2-year Follow-up Study |
| title_full_unstemmed | Impact of Coronary Plaque Vulnerability on Acute Cardiovascular Events – Design of a CT-based 2-year Follow-up Study |
| title_short | Impact of Coronary Plaque Vulnerability on Acute Cardiovascular Events – Design of a CT-based 2-year Follow-up Study |
| title_sort | impact of coronary plaque vulnerability on acute cardiovascular events design of a ct based 2 year follow up study |
| topic | vulnerable plaque acute cardiovascular event systemic inflammation vulnerability markers |
| url | https://doi.org/10.2478/jim-2019-0015 |
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